The degree thesis treats the problem of Global grant in nonprofit sector accorded within Single programming document for Objective 3 of the NUTS 2 Prague region. The Global grant is simplified grant scheme awarded to nonprofit organizations active in social sphere, which focus on persons endangered by social exclusion. The degree thesis defines the theoretical framework of all correlations necessary for valid insight into the problem. Among the concepts defined are nonprofit sector, nonprofit organizations, their financing, regional policy of European Union acting through the European Social Fund awarding funds precisely for Global grant. The nature of Global grant is further examined by looking into project approval procedure falling within the grant, handling of monitoring indicators and positron and impact of the Global grant on nonprofit organizations.