Mussel studies in the Tennessee River drainage (1973 - 1982) examined ecology and distribution and investigated factors limiting to distribution. This river system presently supports 71 freshwater mussel species, 25% of which are endemic to the Cumberlandian Region. Species have been extirpated from this drainage within the past 60 years, however the number of extant species remains high. The major impact of man's activities has been reduction of available habitat. Past and present distribution records indicate that mussel species assemblages are determined by geologic history and stream size. Although some overlap of species exists among stream size categories, there is no longer a continuous gradation from one category to the next; mussels exist in isolated communities separated by nonproductive river reaches. Productive reaches supporting more than 60 mussel species once existed in habitats spanning the transition from medium to large rivers; reaches now altered by impoundment. The maximum number of species reported in recent collections from any one site in the Tennessee drainage is less than 40, which seems to be the maximum number of species niches available. Quantitative sampling reveals characteristic patterns of species dominance. Changes in species dominance and age class structure provide a better basis for evaluating changes over time than do species composition or diversity alone. Mussel density was found to be more variable than species composition, and was unrelated to species abundance. Experiments on effects of siltation indicated that silt can be a significant limiting factor to mussel distribution. Transplant studies showed that mussels transplanted into heavily silted areas exhibited poor survival over a one year period compared to mussels moved to unsilted habitats. Results indicate that siltation may interfere with reproductive activity. Laboratory experiments testing the effect of suspended silt on the uptake of C-14 tagged algae by freshwater mussels showed that suspended silt can interfere with feeding. Food uptake was reduced to approximately 50% (of control) at silt levels of 211 to 820 mg/l, and to 80% at silt levels over 1000 mg/l. It was concluded that the limiting mechanism is one of dilution of food rather than direct interference with filtration or respiration. / Ph. D.