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1	Structure Elucidation of Bioactive Compounds Isolated from Endophytes of Alstonia scholaris and Acmena graveolens Hundley, Nicholas James 02 September 2005 (has links) (PDF) Alstonia scholaris is an evergreen tree native to Southeast Asia and Australia. It is commonly used as a medicinal plant throughout these regions. In the present study, an endophyte of the genus Xylaria was isolated from a stem of Alstonia scholaris, its mycelia and exudate extracted, and the extract assayed for growth inhibition of HeLa cancer cells in vitro. Several known compounds were isolated and identified based on NMR, infrared, and mass spectral data. The compounds identified are 19,20-epoxycytochalasin C; 19,20epoxycytochalasin D; and xylobovide. Two other compounds, fusaric acid and dehydrofusaric acid, were discovered in an endophyte of the Hypocreales family inhabiting the plant Acmena Graveolens. endophtye endophytes endophytic (endophyt) fungi fungal symbiosis rDNA ribosomal DNA fungal taxonomy ITS cytochalasins cytochalasans xylobovide fusaric acid dehydrofusaric acid xylaria xylariaceae rosellinia necatrix taxol HPLC NMR GC gas chromatography MS mass spectrometry (mass spec) IR infrared spectroscopy PCR natural products ethnobotany ethnomedicine COSY HMQC HMBC Biochemistry Chemistry