No description available.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1948. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaf 63).

Presented as Thesis (Ph. D.)--University of Wisconsin--Madison, 1928. / Title from added collective thesis title page. Reprinted from Journal of the American Chemical Society, vol. 52 (1930). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph.D.)--Boston University.. / The purpose of this investigation was to study the periodate oxidation of gelatin obtained from bovine bones in order to determine the conditions necessary for complete oxidation of the hydroxylysine content of the gelatin. The following results were obtained: 1. Amino acid analysis of the bone gelatin preparation agreed with values for bone gelatin found in the literature. 2. The carbohydrate content of the gelatin preparation, expressed as glucose, was determined and found to be .074 umoles of glucose per milligram of nitrogen. 3. Oxidation of the bovine, bone gelatin preparation with sodium periodate in 0.1 N NaOH showed that approximately 65 per cent of the hydroxylysine in a given sample was destroyed in one hour. 4. Kinetic analysis of the periodate reaction in 0.1 N NaOH showed that the oxidation was not a simple first- or second-order reaction. An analysis of the curve, obtained in testing for a first-order reaction, resulted in two first-order components. One of these components had a reaction-rate which was 14 times faster than the rate of the other. The two-component analysis was preferred over others because of its simplicity. 5. Kinetic analysis of periodate reactions at pH levels between 7 and 12 also failed to show that the oxidations were simple first-order reactions. Analysis of the first-order graphs of these reactions made in the same manner as with 0.1 N NaOH showed that the slower component reacted very slowly or not at all. 6. An attempt to correct the first-order reaction graph of gelatin oxidized in 0.1 N NaOH for formaldehyde possibly produced from carbohydrate did not produce a straight line. Thus the carbohydrate was not considered responsible for the failure of the reaction to be firstorder. 7. The results of the oxidations in this study led us to the hypothesis that the hydroxylysine of our bone gelatin exists in two forms: one, which has the reactive site of its side-chain free, is readily available to oxidation by periodate; the other, with its reactive site chemically bound, reacts with periodate at a rate which is dependent on the rapidity with which these bonds may be broken. The implications which these studies have concerning the chemical nature of hydroxylysine in bone gelatin and the factors interfering in periodate oxidations of this gelatin are discussed.

No description available.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1927. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 209-215).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1927. / Typescript. With this are bound: Studies of the optical activity of gelatin systems / by Elmer O. Kraemer and J.R. Fanselow. Reprinted from the Journal of physical chemistry, vol. XXIX (Sep. 1925), p. [1169]-1177 -- The optical activity and colloidal behavior of aqueous gelatin dispersions / by Elmer O. Kraemer and J.R. Fanselow. Reprinted from the Journal of physical chemistry, vol. XXXII (June 1928), p. [894]-911 -- The influence of electrolytes and non-electrolytes upon the optical activity and relative resistance to shear of gelatin systems / By J.R. Fanselow. From Colloid symposium monograph, [1928], p. 237-252. Includes bibliographical references (leaves 191-193).

Diss. (Doktor biologicheskikh nauk)--Kharkov 1939? / At head of title: ... Kharʹkovskiĭ gosudarstvennyĭ universitet im. A.M. Gorʹkogo. Added t.p. in English: ... Principles of senescence of gelatine sols and jellies; materials on senescence of biocolloids. "Dannai︠a︡ rabota ... byla premirovana Vsesoi︠u︡znym komitetom po sorevnovanii︠u︡ molodykh nauchnykh rabotnikov, provodimomu T︠S︡K VLKSM v oznamenovanie dvadt︠s︡atoĭ godovshchiny Velikoĭ okti︠a︡brʹskoĭ sot︠s︡ialisticheskoĭ revoli︠u︡t︠s︡ii v SSSR."--P. [5]. "Literatura" (Bibliography): p. 97-[101].

Proefschrift--Utrecht. / "Stellingen" ([2] p.) laid in.

Gelatin's ability to dissolve in water while also forming a gel upon cooling, produces melt in your mouth candies and frozen desserts, along with hard and soft capsules and tablets. This protein, which is extracted from pork skin and cattle hide, is categorized by a rigidity or stiffness value and remains one of the most common materials in food and pharmaceutical formulations. Its established use and safe certification are appealing characteristics for manipulation into nanoparticles (NPs) to encapsulate therapeutic molecules as medicine. NPs are generally spherical materials, yet their abilities hold great promise to improve medical outcomes. These abilities include: protecting molecules from harsh locations like the stomach, improved therapeutic delivery through biological barriers such as the brain and controlled release for minimal side effects. NPs typically less than 200 nanometers (nm) overcome biological barriers more effectively than larger particles. For reference, 200 nm is equivalent to dividing the length of an ant (~4 millimeters) by 20,000. The potential applications of gelatin NPs to treat disease is impressive; however, an inability to consistently obtain ideal NP sizes (<200 nm average diameter) exists. Furthermore, gelatin NPs are commonly stabilized (or cross-linked) using toxic chemicals. The motivation for this research was to (1) contribute new understanding why ideal gelatin NPs are difficult to obtain and (2) form NPs using a non-toxic chemical for prospective brain injury treatment. This dissertation determined low rigid and high rigid gelatin can consistently form NPs less than 200 nm, indicating rigidity alone is not a main factor for obtaining ideal NPs. Instead, characterization approaches indicated gelatin sample composition prior to NP formation must be very uniform. As a result, filtering solutions prior to NP formation proved a new technique to prepare ideal NPs. Glyceraldehyde is a sugar and has shown to be a non-toxic gelatin NP stabilizer. For the first time, glyceraldehyde's non-toxicity was shown using various brain cell types and NPs were formed to be ~130 nm. After incorporation of a new therapeutic molecule for brain injury treatment, average particles were ~149 nm with slow therapeutic release profiles determined in simulated body fluid. / Ph. D. / Gelatin’s ability to dissolve in water while also forming a gel upon cooling, produces “melt in your mouth” candies and frozen desserts, along with hard and soft capsules and tablets. This protein, which is extracted from pork skin and cattle hide, is categorized by a rigidity or stiffness value and remains one of the most common materials in food and pharmaceutical formulations. Its established use and safe certification are appealing characteristics for manipulation into nanoparticles (NPs) to encapsulate therapeutic molecules as medicine. NPs are generally spherical materials, yet their abilities hold great promise to improve medical outcomes. These abilities include: protecting molecules from harsh locations like the stomach, improved therapeutic delivery through biological barriers such as the brain and controlled release for minimal side effects. NPs typically less than 200 nanometers (nm) overcome biological barriers more effectively than larger particles. For reference, 200 nm is equivalent to dividing the length of an ant (~4 millimeters) by 20,000. The potential applications of gelatin NPs to treat disease is impressive; however, an inability to consistently obtain ideal NP sizes (<200 nm average diameter) exists. Furthermore, gelatin NPs are commonly stabilized (or cross-linked) using toxic chemicals. The motivation for this research was to (1) contribute new understanding why ideal gelatin NPs are difficult to obtain and (2) form NPs using a non-toxic chemical for prospective brain injury treatment. This dissertation determined low rigid and high rigid gelatin can consistently form NPs less than 200 nm, indicating rigidity alone is not a main factor for obtaining ideal NPs. Instead, characterization approaches indicated gelatin sample composition prior to NP formation must be very uniform. As a result, filtering solutions prior to NP formation proved a new technique to prepare ideal NPs. Glyceraldehyde is a sugar and has shown to be a non-toxic gelatin NP stabilizer. For the first time, glyceraldehyde’s non-toxicity was shown using various brain cell types and NPs were formed to be ~130 nm. After incorporation of a new therapeutic molecule for brain injury treatment, average particles were ~149 nm with slow therapeutic release profiles determined in simulated body fluid.