The general aim of this thesis is to further undermine the convention that British moral philosophy of the early eighteenth century is best conceived as a struggle between rationalist and sentimentalist epistemologies. I argue that the philosophers considered here (Samuel Clarke, Francis Hutcheson, Gilbert Burnet, John Balguy and John Gay) situated their moral epistemologies within the wider framework of an attempt to prove the ‘reality' of virtue in terms of virtue being an achievable, practical endeavour. To this end, they were as much concerned with the attributes that motivated or caused God to create in the way that he did – his communicable attributes - as they were with our own natural moral abilities. I maintain that this concern led Clarke, Burnet and Balguy to look beyond a rationalist epistemology in an attempt to account for the practical possibility of moral action. I claim that it led Hutcheson to develop a moral theory that reflected a realist theistic metaphysics that went some way beyond an appeal to providential naturalism. I argue that it led Gay to try to synthesise the approaches of rival moral schemes in order to offer a unified account of agency and obligation. The thesis has three key objectives: 1) to examine the relationship of rationalism to obligation and motivation in the work of Clarke, Burnet and Balguy, and 2) to explore the relative roles of sense and judgment in the moral epistemologies of Hutcheson, Burnet, Balguy and Gay and to (re) examine the nature of Hutcheson's moral realism, and 3) to investigate the theistic metaphysical claims made by all parties with respect to their arguments about moral realism.

This thesis focuses on finding a possible link between genotype typical for Gilberts syndrome and specific diseases. It nvestigates a possible protective effect of the 7TA allele. It explains the origin, symptoms, pathology of this syndrome and its consequences for clinical medicine. Possible protective effect of this polymorphic mutation including reduced incidence of vascular diseases (myocardial infarction, stroke, atherosclerosis, etc.). is discussed. Reduced oxidative stress in hyperbilirubinaemia can be the mechanism behind. The work was carried out in the co-operation with the GENVIA laborator.

A vegetation monitoring study was conducted from 1998 to 2013 at Camp Grafton South (CGS) in Eddy County, North Dakota to assess how climatic, grazing, and military training disturbance affects plant community composition. The objectives of this study were to 1) describe the prairie vegetation at CGS across three topographic positions and 2) explore any shifts in plant community composition in correlation with time. Frequency data was collected at 45 randomly selected transects on lowland, midland, and upland grassland plant communities on native prairie. Plant communities were compared using non-metric multidimensional scaling (NMS) ordination. NMS ordination showed that the three plant communities were distinct from one another, and that the frequency of the invasive graminoids Kentucky bluegrass (Poa pratensis L.) and smooth brome (Bromus inermis Leyss.) increased. Increases in precipitation, temperature, and growing season days appear to be the primary influence on the changes in plant communities from 1998-2013.

The operas by playwright W. S. Gilbert and composer Arthur Sullivan have been considered some of the most popular and successful pieces of musical theatre in the English language. While their joint creative output neared perfection, Gilbert and Sullivan's working relationship was fraught with conflict. The two men's opposing personalities led them to favor disparate styles and work towards different goals. However, the ability to balance contrasting tones, such as sarcasm and sympathy, resulted in their overwhelming success. I analyze this "winning formula" by looking at the influence of feminism, especially the "New Woman" literary movement, on the works of Gilbert & Sullivan. Gilbert frequently used common female stereotypes and gave his female characters humorous yet demeaning flaws that kept the audience from fully admiring them. Sullivan, on the other hand, countered Gilbert's derisive attitude by composing sophisticated music for the female characters, granting emotional depth and a certain level of respectability. The struggle between Gilbert's mocking tone and Sullivan's empathetic music led to the men's ultimate success. I examine Gilbert's female characters, explore the counteractive effect of Sullivan's music, and analyze Princess Ida—their opera most directly related to the New Woman—in depth.

My thesis will encompass the completion of the lighting design for W. S. Gilbert and Sir Arthur Sullivan's opera The Mikado and a post-production written documentation of the entire production process. The thesis will involve the completion of a lighting design with all of its accompanying paperwork generated in AutoCAD and Excel. The design will require lights for a two-act, multi-locational musical. Lights will need to provide a bright environment that can transform to the various locales. The entire design process will involve close communication with the entire design team, the director and the shop crew. As lighting designer, I will have to communicate with the Master Electrician and instruct him or her on the proper hang and circuiting of all instruments and provide detailed paperwork to ensure the light plot is hung correctly. With the Master Electricians help I will focus and gel all instruments. As lighting designer, I will also write cues and any special lighting effects for the show. During technical rehearsal week I will continue to maintain close communication with the director, making any necessary changes to create a better artistic product. The whole process will involve close collaboration with all of the design areas and an open communication so that lights enhance all elements of the show. As lighting designer, I will have to develop a vocabulary to communicate the abstract ideas of light and communicate them well enough so that the final product is both what the director and I imagined. During this process, I will maintain a journal that details the steps throughout the process and will act as a record of the discoveries and setbacks that occur. I will also provide research to support all of my creative decisions. I will also provide a strong informed basis for the design. The written portion of the Thesis will document the design process from early concept discussions through the completion and opening of the show. The thesis will examine the artistic developments and growth, as well as reflect on the overall success and development of the design. The personal journals maintained throughout the process will be edited and included for insight into daily growth of the design. The inclusion of these journals will also provide insight into the working relationship and nature of my collaboration with all the departments.

No description available.

Neste trabalho se busca pensar a individuação conjunta do corpo e do som, através da improvisação e segmentos de roteiros performáticos. Assim, colhemos traços metodológicos da atuação teatral para pensar as relações entre produção de corpo, som e vocalização. Para fazer jus a essa lógica, cada segmento da tese se debruçou em uma prática produtiva de corpo: caminhada, desenho e conversação. Guiei-me, para esse campo operativo, na noção de transdução, conforme trabalhada por Gilbert Simondon. É escritura, portanto, experimental, que compromete o tecido argumentativo de uma tese com procedimentos oriundos de outros ambientes, mais instáveis, como a precariedade do caderno. Referência vitalista nesse caso é o Artaud tardio (1943-1948). Focalizamos, em sobreposição, as práticas dos núcleos de corpossom, coletivos de dimensões artístico-pedagógicas que se envolveram no trabalho acima descrito. / In this work we seek to think about the combined individuation of body and sound, through improvisation and segments of performance routines. Thus, we collect methodological traits of theatrical performance to think about relations between body generation, sound and vocalization. To make justice to this logic, each segment of the thesis has looked over on a generative body practice: walking, drawing and conversation. I guided myself, for this operative field, by the notion of transduction, as worked by Gilbert Simondon. It is scripture, therefore, experimental, which compromises the argumentative fabric of a thesis with procedures from other, more unstable environments, such as the precariousness of the notebook. Vitalist reference in this case is the last Artaud (1943-1948). We focused, in overlapping, the practices of the nuclei of corpossom [bodysound], collective of artistic-pedagogical dimensions that were involved in the work described above.

Née en 1464 au château Saint Georges de Mantoue, Claire de Gonzague grandit au sein d'une cour très raffinée, celle des marquis de Gonzague, condottieres et mécènes, commanditaires du peintre le plus réputé de l'époque, Andrea Mantegna. Après son mariage en 1481 avec le comte Gilbert de Bourbon-Montpensier, elle devient dame d'honneur de la reine Anne de Bretagne et accueille des artistes et des réfugiés italiens dans son château d'Aigueperse. A partir de 1493, la comtesse joue un rôle d'intermédiaire entre son frère François de Gonzague et le roi de France. Lors de la première campagne d'Italie en septembre 1494, Gilbert de Montpensier accompagne Charles VIII, qui le nomme vice-roi de Naples l'année suivante. C'est à Mantoue où elle est l'hôte de sa belle-soeur Isabelle d'Este que Claire apprend la mort de son époux le 9 novembre 1496 à Pouzzoles. Devenue veuve, elle bénéficie de la protection du roi et tente de jouer un rôle politique, incitant François à maintenir de bons rapports avec Louis XII qui, après le duché de Milan, envisage de conquérir le petit marquisat. Tout au long de la crise politique de 1500, la comtesse met son talent de négociatrice au service de son frère pour sauver son état. Epuisée par la maladie qui la ronge depuis de nombreuses années, elle meurt très chrétiennement le 2 juin 1503. Selon son désir, elle est inhumée dans la Sainte-Chapelle d'Aigueperse auprès de son époux Gilbert de Bourbon-Montpensier. / Born in 1464 in Saint George's castle in Mantoue, Claire of Gonzague grows up in the heart of a very sophisticated court, the marquess of Gonzague's court, "condottieres" and sponsors, protectors of the most famous painter in this time, Andrea Mantegna. After her marriage in 1481 with the count Gilbert of Bourbon-Montpensier, she becomes maid of honour for the queen Ann of Britain and receives artists and Italian refugees in Aigueperse's castle. From 1493, the countess plays a role of an agent between her brother François of Gonzague and the king of the France. During the first campaign of Italy in september 1494, Gilbert of Montpensier escorts Charles VIII who promotes him to the rank of vice-king of Naples the next year. It's in Mantoue, where she is the guest of her sister-in-law, Isabelle of Este that Claire hears of her husband's death on the 9th of november in 1496 in Pouzzoles. As a widow, she gets the protection of the king and tries to play a politicak part, encouraging François to keep good relations with Louis XII who, after Milan's dukedom, contemplates conquering the little marquisate. During the political crisis of 1500, the countess uses her singular aptitude for saving her brothes's state. Exhausted by a progressive illness years, she dies as a true Christian on the 2nd of june 1503. In accordance to her wish, she is buried in the Aigueperse's Holy Chapel near her husband Gilbert of Bourbon-Montpensier.

A Síndrome de Gilbert é caracterizada por uma hiperbilirrubinemia indireta benigna que ocorre na ausência de hemólise ou doença estrutural do fígado. Manifesta-se por episódios intermitentes de icterícia, desencadeados por exposição a estressores físicos, baixa ingesta calórica, entre outros. A base genética da redução da atividade da enzima UDP - Glucoroniltransferase foi descoberta em 1995: em uma população caucasiana. Todos os pacientes estudados apresentaram uma adição dos nucleotídeos Timina-Adenina (TA) na região TATA box presente no promotor do gene UGT1A1, em ambos os alelos. Embora considerada uma condição benigna, a síndrome de Gilbert tem sido recentemente associada à hiperbilirrubinemia e a outros efeitos colaterais na utilização de algumas drogas como o Indinavir e Irinotecan. Outro ponto importante diz respeito ao nível de bilirrubina sérica como um indicador da severidade do acometimento de hepatopatas. A presença de mutação no gene UGT1A1 em pacientes hepatopatas pode levar ao aumento da bilirrubina sérica, supervalorizando o acometimento hepático da condição patológica. O objetivo deste estudo foi verificar a frequência do alelo UGT1A1*28 em doadores de sangue da Fundação Pró-sangue Hemocentro de São Paulo HC-FMUSP e em pacientes portadores de hepatite crônica C atendidos no ambulatório de Gastroenterologia Clínica da FMUSP. Relacionar o genótipo TA7/7 com o aumento de bilirrubina sérica nos pacientes com hepatite crônica C e avaliar a técnica de análise de fragmento no rastreamento e genotipagem da Síndrome de Gilbert. A frequência encontrada para o genótipo TA7/7 no grupo doador foi de 9% (30/313) e no grupo de pacientes VHC, de 10% (51/494). O genótipo TA7/7 parece estar relacionado com o aumento de bilirrubina. A técnica de análise de fragmentos mostrou-se rápida, sendo possível para fazer uma análise em grande escala. A herança genética da população brasileira é muito heterogênea. É constituída de caucasianos, africanos, indios, orientais e outros. Os dados sugerem que a variação genética da região promotora do gene UGT1A1 é alta entre pacientes com bilirrubina maior que 1mg/dL, e que a genotipagem para UGT1A1*28 deve ser considerada na avaliação dos pacientes com hepatite C crônica com hiperbilirrubinemia. / Gilberts syndrome is a benign condition characterized by unconjugated hiperbilurubinemia that occurs in the absence of hemolysis or liver chronic disease. It is clinically manifested by intermittently jaundice, triggered by exposition to physical stress, low calory diet, among others. The genetic base is the reduction of the activity of UDP-glucuronosyltransferase enzyme described in 1995: in a Caucasian population, all patients studied presented a Thymine Adenine (TA) addition in the TATA box region in both alleles of the UGT1A1 gene promoter. Although, Gilberts syndrome has been considered a benign condition, recently it has been associated to hiperbilirrubinemia and other adverse events during the utilization of some drugs such as Indinavir and Irinotecan. Another important issue to consider is that bilirubin is used to evaluate the severity of liver dysfunction in chronic liver diseases. The presence of this mutation in those patients could increase bilirubin levels, overestimating liver damage. The aim of this study were: 1) to verify the frequency of the genotype UGT1A1*28 (TA7/7) in blood donors and in chronic hepatitis C patients from the Gastroenterology outpatients clinics of the University of São Paulo School of Medicine; 2) to establish a relationship with TA7/7 genotype and bilirubin elevation in chronic hepatitis C patients and 3) to evaluate the fragment analysis technique to screening and genotyping the Gilbert syndrome. The frequencies of TA7/7 genotype found in blood donors group were 9.6% (30/313) and in the chronic hepatitis C group were 10% (51/494). The TA7/7 genotype seems to be related with increase of bilirubin. The fragment analysis technique is fast and able to a large scale screening approach. The genetic background of Brazilian population is highly heterogeneous. It is comprised of Caucasians, Africans, Indians, Orientals and others. The data suggests that genetic variation of promoter region of UGT1A1 gene is high among patients with bilirubin levels greater than 1 mg/dl, and UGT1A1*28 genotypes should be considered when evaluating chronic hepatitis C patients with hiperbilirubinemia.

A Síndrome de Gilbert é caracterizada por uma hiperbilirrubinemia indireta benigna que ocorre na ausência de hemólise ou doença estrutural do fígado. Manifesta-se por episódios intermitentes de icterícia, desencadeados por exposição a estressores físicos, baixa ingesta calórica, entre outros. A base genética da redução da atividade da enzima UDP - Glucoroniltransferase foi descoberta em 1995: em uma população caucasiana. Todos os pacientes estudados apresentaram uma adição dos nucleotídeos Timina-Adenina (TA) na região TATA box presente no promotor do gene UGT1A1, em ambos os alelos. Embora considerada uma condição benigna, a síndrome de Gilbert tem sido recentemente associada à hiperbilirrubinemia e a outros efeitos colaterais na utilização de algumas drogas como o Indinavir e Irinotecan. Outro ponto importante diz respeito ao nível de bilirrubina sérica como um indicador da severidade do acometimento de hepatopatas. A presença de mutação no gene UGT1A1 em pacientes hepatopatas pode levar ao aumento da bilirrubina sérica, supervalorizando o acometimento hepático da condição patológica. O objetivo deste estudo foi verificar a frequência do alelo UGT1A1*28 em doadores de sangue da Fundação Pró-sangue Hemocentro de São Paulo HC-FMUSP e em pacientes portadores de hepatite crônica C atendidos no ambulatório de Gastroenterologia Clínica da FMUSP. Relacionar o genótipo TA7/7 com o aumento de bilirrubina sérica nos pacientes com hepatite crônica C e avaliar a técnica de análise de fragmento no rastreamento e genotipagem da Síndrome de Gilbert. A frequência encontrada para o genótipo TA7/7 no grupo doador foi de 9% (30/313) e no grupo de pacientes VHC, de 10% (51/494). O genótipo TA7/7 parece estar relacionado com o aumento de bilirrubina. A técnica de análise de fragmentos mostrou-se rápida, sendo possível para fazer uma análise em grande escala. A herança genética da população brasileira é muito heterogênea. É constituída de caucasianos, africanos, indios, orientais e outros. Os dados sugerem que a variação genética da região promotora do gene UGT1A1 é alta entre pacientes com bilirrubina maior que 1mg/dL, e que a genotipagem para UGT1A1*28 deve ser considerada na avaliação dos pacientes com hepatite C crônica com hiperbilirrubinemia. / Gilberts syndrome is a benign condition characterized by unconjugated hiperbilurubinemia that occurs in the absence of hemolysis or liver chronic disease. It is clinically manifested by intermittently jaundice, triggered by exposition to physical stress, low calory diet, among others. The genetic base is the reduction of the activity of UDP-glucuronosyltransferase enzyme described in 1995: in a Caucasian population, all patients studied presented a Thymine Adenine (TA) addition in the TATA box region in both alleles of the UGT1A1 gene promoter. Although, Gilberts syndrome has been considered a benign condition, recently it has been associated to hiperbilirrubinemia and other adverse events during the utilization of some drugs such as Indinavir and Irinotecan. Another important issue to consider is that bilirubin is used to evaluate the severity of liver dysfunction in chronic liver diseases. The presence of this mutation in those patients could increase bilirubin levels, overestimating liver damage. The aim of this study were: 1) to verify the frequency of the genotype UGT1A1*28 (TA7/7) in blood donors and in chronic hepatitis C patients from the Gastroenterology outpatients clinics of the University of São Paulo School of Medicine; 2) to establish a relationship with TA7/7 genotype and bilirubin elevation in chronic hepatitis C patients and 3) to evaluate the fragment analysis technique to screening and genotyping the Gilbert syndrome. The frequencies of TA7/7 genotype found in blood donors group were 9.6% (30/313) and in the chronic hepatitis C group were 10% (51/494). The TA7/7 genotype seems to be related with increase of bilirubin. The fragment analysis technique is fast and able to a large scale screening approach. The genetic background of Brazilian population is highly heterogeneous. It is comprised of Caucasians, Africans, Indians, Orientals and others. The data suggests that genetic variation of promoter region of UGT1A1 gene is high among patients with bilirubin levels greater than 1 mg/dl, and UGT1A1*28 genotypes should be considered when evaluating chronic hepatitis C patients with hiperbilirubinemia.