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Thesis (Ph. D.)--Institute of Paper Chemistry, 1971. / Includes bibliographical references (leaves 72-75).

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1983. / Extra t.p. with thesis statement inserted. Includes the author's four published papers. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (doctoral)--Lund University, 1998. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1983. / Extra t.p. with thesis statement inserted. Includes the author's four published papers. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

After discussing the condensation portion of methylglucoside with benzaldehyde and the chemistry of the product, the structure of benzylidene methylglucoside, together with that of the dimethyl glucose, is reviewed. A few observations upon the effect of the substitutions upon the molecular rotation of methylglucoside is then inserted before an account is given of the chemical behaviour of dimethyl glucose, as contrasted with that of the unsubstituted sugar. Finally, the experiments on which the Thesis is based, prefaced by notes explaining the technique adopted, complete the work.

This study concerns an investigation of nitrous acid deamination of various amino sugar derivatives. Deamination reagents have also been used for the diazotization of aromatic compounds. Nitrous acid deamination was used in the deamination of amino acids pinacolic amino alcohols and amino sugars.

Plant β-glucosidases (β-D-glucoside glucohydrolases, E.C. 3.2.1.21) are known to function in defense in cyanogenic systems, and may also function in the metabolism of phytohormone glucosides and glucosides of other secondary plant products. Maize (Zea mays L.) β-glucosidase is a homodimer of 60 KD monomers and occurs in the plastid. Numerous glycosides were tested as substrates and K_m's and V_m's were determined. Various compounds were also tested as inhibitors and K_i's and/or K_i’ 's were estimated. 4- methylumbelliferyl-β-D-glucoside was the best substrate (K_m=0.14 mM) for which kinetic data were obtained. Monosaccharides were poor inhibitors. The best competitive inhibitors were D-gluconic acid lactone, dhurrin, and 2,4- dihydroxy-7-methoxy-2H-1, 4-benzoxazin-3(4H)-one (DIMBOA) (K_i's< 1 mM). The enzyme had broad substrate specificity and could cleave many glycosides with hydrophobic aglycones. One major substrate, the hydroxamic acid 2,4-dihydroxy-7- methoxy-1, 4-benzoxazin-3-one-8-D-glucopyranoside (DIMBOA-glc), was found in methanolic maize extracts. Increasing DIMBOA levels are associated with increasing resistance to several pests. The highest levels of enzyme activity and hydroxamic acids along K55 and H95 shoot length were found near the node. Tissue distribution of hydroxamic acids and β-glucosidase activity was also determined. In K55, both were found in the stele of the mesocotyl, the young leaves, and associated with the vascular bundles of the coleoptile. A major function of the enzyme is to mediate insect and pathogen resistance via the release of the toxic aglycone DIMBOA. / Master of Science