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A research model for the scientific investigation of homoeopathyBaker, Don G Unknown Date (has links)
Homoeopathy is a controversial form of medicine that is governed by the premise that highly diluted substances that can a defined set of symptoms in a healthy person can cure a similar set of symptoms in a non-healthy person. The use of highly diluted homoeopathic substances that may no longer be expected to contain any trace of the original substance is contrary to accepted pharmacological theory. In addition to serial dilution, homoeopathic “potentisation” of substances also includes violent agitation of the substance at each dilution step, a process known as “succussion”. The role of this process is not understood. The fact that the mechanism of action of homoeopathic substances is unknown adds to the controversial nature of this therapy.A review of the literature demonstrated that a more rigorous approach to the research of homoeopathy was needed in order to investigate whether homoeopathy could be investigated within a scientifically appropriate context. It was initially proposed that, through the successful replication of an existing trial, a series of clinical trials based on this replication could be conducted to test fundamental questions of homoeopathy. For pragmatic reasons, this initial approach was abandoned. A novel protocol that was subsequently designed to scientifically evaluate the effects of homoeopathy, in particular, the homoeopathic treatment of osteoarthritis of the knee and hip, was subsequently developed.A description of homoeopathy, its development, its placement within the scientific paradigm and its role in the treatment of various clinical conditions is reviewed in Chapter 1. From this literature review, hypotheses were generated to test the effect of the homoeopathic treatment of osteoarthritis. Chapter 2 describes the selection process and proposed replication of a prior clinical trial with a successful outcome upon which to base a further series of clinical trials to test fundamental questions in homoeopathy. The selected study was a randomised, double-blind clinical trial designed to compare the effects of a complex homoeopathic preparation with the effects of paracetamol in the treatment of osteoarthritic knee pain. The study was prematurely terminated when another study presented evidence that the analgesic effect of paracetamol was no better than placebo. The uncertainty that paracetamol was no better than placebo raised doubts as to the validity of any outcome had the trial proceeded. The proposal to develop a series of clinical trials replicating the protocol of this study was postponed as a consequence.Chapter 3 describes the subsequent formation of a ‘think tank’ consisting of epidemiologists, biostatisticians, clinical researchers in complementary medicine and homoeopaths and the subsequent development of a rigorous research protocol for the investigation of homoeopathy within the scientific paradigm. This homoeopathic research model and is described in detail.Chapter 4 describes a randomised, double-blind, placebo-controlled trial with five arms designed to evaluate both the research model and the homoeopathic treatment of osteoarthritis of the hip and knee.Chapter 5 details the results of this clinical trial. No significant difference was demonstrated between individualised homoeopathic treatment, generic complex homoeopathic treatments or placebo. Furthermore, no positive effect on treatments was demonstrated by the inclusion of a full homoeopathic consultation.Chapter 6 provides a discussion of the clinical trial. Possible reasons for the discrepancy between the hypothesised outcomes and the results of the clinical trial are explored and directions for future research are suggested.
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A research model for the scientific investigation of homoeopathyBaker, Don G Unknown Date (has links)
Homoeopathy is a controversial form of medicine that is governed by the premise that highly diluted substances that can a defined set of symptoms in a healthy person can cure a similar set of symptoms in a non-healthy person. The use of highly diluted homoeopathic substances that may no longer be expected to contain any trace of the original substance is contrary to accepted pharmacological theory. In addition to serial dilution, homoeopathic “potentisation” of substances also includes violent agitation of the substance at each dilution step, a process known as “succussion”. The role of this process is not understood. The fact that the mechanism of action of homoeopathic substances is unknown adds to the controversial nature of this therapy.A review of the literature demonstrated that a more rigorous approach to the research of homoeopathy was needed in order to investigate whether homoeopathy could be investigated within a scientifically appropriate context. It was initially proposed that, through the successful replication of an existing trial, a series of clinical trials based on this replication could be conducted to test fundamental questions of homoeopathy. For pragmatic reasons, this initial approach was abandoned. A novel protocol that was subsequently designed to scientifically evaluate the effects of homoeopathy, in particular, the homoeopathic treatment of osteoarthritis of the knee and hip, was subsequently developed.A description of homoeopathy, its development, its placement within the scientific paradigm and its role in the treatment of various clinical conditions is reviewed in Chapter 1. From this literature review, hypotheses were generated to test the effect of the homoeopathic treatment of osteoarthritis. Chapter 2 describes the selection process and proposed replication of a prior clinical trial with a successful outcome upon which to base a further series of clinical trials to test fundamental questions in homoeopathy. The selected study was a randomised, double-blind clinical trial designed to compare the effects of a complex homoeopathic preparation with the effects of paracetamol in the treatment of osteoarthritic knee pain. The study was prematurely terminated when another study presented evidence that the analgesic effect of paracetamol was no better than placebo. The uncertainty that paracetamol was no better than placebo raised doubts as to the validity of any outcome had the trial proceeded. The proposal to develop a series of clinical trials replicating the protocol of this study was postponed as a consequence.Chapter 3 describes the subsequent formation of a ‘think tank’ consisting of epidemiologists, biostatisticians, clinical researchers in complementary medicine and homoeopaths and the subsequent development of a rigorous research protocol for the investigation of homoeopathy within the scientific paradigm. This homoeopathic research model and is described in detail.Chapter 4 describes a randomised, double-blind, placebo-controlled trial with five arms designed to evaluate both the research model and the homoeopathic treatment of osteoarthritis of the hip and knee.Chapter 5 details the results of this clinical trial. No significant difference was demonstrated between individualised homoeopathic treatment, generic complex homoeopathic treatments or placebo. Furthermore, no positive effect on treatments was demonstrated by the inclusion of a full homoeopathic consultation.Chapter 6 provides a discussion of the clinical trial. Possible reasons for the discrepancy between the hypothesised outcomes and the results of the clinical trial are explored and directions for future research are suggested.
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A research model for the scientific investigation of homoeopathyBaker, Don G Unknown Date (has links)
Homoeopathy is a controversial form of medicine that is governed by the premise that highly diluted substances that can a defined set of symptoms in a healthy person can cure a similar set of symptoms in a non-healthy person. The use of highly diluted homoeopathic substances that may no longer be expected to contain any trace of the original substance is contrary to accepted pharmacological theory. In addition to serial dilution, homoeopathic “potentisation” of substances also includes violent agitation of the substance at each dilution step, a process known as “succussion”. The role of this process is not understood. The fact that the mechanism of action of homoeopathic substances is unknown adds to the controversial nature of this therapy.A review of the literature demonstrated that a more rigorous approach to the research of homoeopathy was needed in order to investigate whether homoeopathy could be investigated within a scientifically appropriate context. It was initially proposed that, through the successful replication of an existing trial, a series of clinical trials based on this replication could be conducted to test fundamental questions of homoeopathy. For pragmatic reasons, this initial approach was abandoned. A novel protocol that was subsequently designed to scientifically evaluate the effects of homoeopathy, in particular, the homoeopathic treatment of osteoarthritis of the knee and hip, was subsequently developed.A description of homoeopathy, its development, its placement within the scientific paradigm and its role in the treatment of various clinical conditions is reviewed in Chapter 1. From this literature review, hypotheses were generated to test the effect of the homoeopathic treatment of osteoarthritis. Chapter 2 describes the selection process and proposed replication of a prior clinical trial with a successful outcome upon which to base a further series of clinical trials to test fundamental questions in homoeopathy. The selected study was a randomised, double-blind clinical trial designed to compare the effects of a complex homoeopathic preparation with the effects of paracetamol in the treatment of osteoarthritic knee pain. The study was prematurely terminated when another study presented evidence that the analgesic effect of paracetamol was no better than placebo. The uncertainty that paracetamol was no better than placebo raised doubts as to the validity of any outcome had the trial proceeded. The proposal to develop a series of clinical trials replicating the protocol of this study was postponed as a consequence.Chapter 3 describes the subsequent formation of a ‘think tank’ consisting of epidemiologists, biostatisticians, clinical researchers in complementary medicine and homoeopaths and the subsequent development of a rigorous research protocol for the investigation of homoeopathy within the scientific paradigm. This homoeopathic research model and is described in detail.Chapter 4 describes a randomised, double-blind, placebo-controlled trial with five arms designed to evaluate both the research model and the homoeopathic treatment of osteoarthritis of the hip and knee.Chapter 5 details the results of this clinical trial. No significant difference was demonstrated between individualised homoeopathic treatment, generic complex homoeopathic treatments or placebo. Furthermore, no positive effect on treatments was demonstrated by the inclusion of a full homoeopathic consultation.Chapter 6 provides a discussion of the clinical trial. Possible reasons for the discrepancy between the hypothesised outcomes and the results of the clinical trial are explored and directions for future research are suggested.
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The efficacy of a homeopathic complex on the symptoms of osteoarthritis of the hand in femalesMukansi, Phathiswa 11 June 2012 (has links)
M.Tech.
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The efficacy of a homoeopathic complex (Aconitum napellus 30CH, Arnica montana 30CH and China officinalis 30CH) on the transport of broiler chickens to the abattoir, in terms of mortality rate, damage and weight lossEatwell, Alan Rowan January 2003 (has links)
Thesis (M.Tech.: Homoeopathy) -Dept. of Homoeopathy, Durban Institute of Technology, 2003
xi, 59 leaves / The purpose of this placebo-controlled study was to evaluate the effect of a Homoeopathic complex (Aconitum napelus 30CH, Arnica montana 30CH and China officinalis 30CH) on broiler chickens being transported to the abattoir.
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The efficacy of a homoeopathic complex (Aconitum napellus 30CH, Arnica montana 30CH and China officinalis 30CH) on the transport of broiler chickens to the abattoir, in terms of mortality rate, damage and weight lossEatwell, Alan Rowan January 2003 (has links)
Thesis (M.Tech.: Homoeopathy) -Dept. of Homoeopathy, Durban Institute of Technology, 2003
xi, 59 leaves / The purpose of this placebo-controlled study was to evaluate the effect of a Homoeopathic complex (Aconitum napelus 30CH, Arnica montana 30CH and China officinalis 30CH) on broiler chickens being transported to the abattoir.
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Case studies on the effect of the homoeopathic similimum in black females with premenstrual syndromeMudzanani, Mainganye Lydo 04 June 2012 (has links)
M.Tech. / Premenstrual syndrome affects millions of premenopausal women and has been described as one of the most common disorders in women. Premenstrual syndrome (PMS) is defined as the cyclic recurrence of symptoms such as anxiety, depression, food cravings, bloating, breast tenderness, and headaches during the luteal phase (from day fourteen to day one) of the menstrual cycle (Nel, 1995). PMS has been estimated to affect 75% of women of reproductive age, and there are no optimal conventional treatment options available (Steiner et al., 2006). Research has found an increased incidence of PMS in black women (Deuster et al., 1999). Due to the high number of women suffering from PMS and side-effects of conventional medicine, a safe alternative treatment for PMS is required. The homoeopathic similimum method involves prescribing one remedy at a time in optimal potency and repetition based on the totality of the individual patient’s mental, emotional and physical symptoms (Vithoulkas, 1985).
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The efficacy of a topical naturopathic complex (Allium sativum MT, Hydrastis canadensis MT, Apis mellifica D3 and Urtica urens D3) in the treatment of Tinea pedisMaharaj, Prashadhna Devi January 2006 (has links)
Thesis (M.Tech.: Homoeopathy)-Dept. of Homoeopathy, Durban Institute of Technology, 2006
xx, 108 leaves / Tinea pedis, more commonly known as “Athlete’s foot”, is a common acute infection that occurs in warm, humid climates (Fitzpatrick, et al. 1992:98).
Warmth, humidity, trauma and occlusion such as non-breathable footwear increase the susceptibility to infection (Prescott, et al. 1999:814). The infection can become chronic in people who are more susceptible such as patients who are immuno-suppressed or those who have Diabetes mellitus (al Hassan, et al.
2004: 1).
The aim of this placebo-controlled double-blind study was to evaluate the
effectiveness of a topical naturopathic complex comprising of Allium sativum mother tincture (Ø), Hydrastis canadensis (Ø), Apis mellifica (D3) and Urtica urens (D3) (in an aqueous cream base) in the treatment of Tinea pedis. The complex utilized in this study is regarded as naturopathic because the remedies
comprising the complex were selected for the following reasons:
•Allium sativum and Hydrastis canadensis, each utilized in mother tincture, were selected for their antifungal properties.
•Apis mellifica and Urtica urens, each utilized in D3 potency were selected
because their skin symptomotology most accurately matched the symptoms associated with “Athlete’s foot”.
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The efficacy of a topical naturopathic complex (Allium sativum MT, Hydrastis canadensis MT, Apis mellifica D3 and Urtica urens D3) in the treatment of Tinea pedisMaharaj, Prashadhna Devi January 2006 (has links)
Mini-dissertation submitted in partial compliance with the requirements of the Master's Degree in Technology: Homoeopathy, Durban Institute of Technology, 2006. / Tinea pedis, more commonly known as “Athlete’s foot”, is a common acute infection that occurs in warm, humid climates (Fitzpatrick, et al. 1992:98).
Warmth, humidity, trauma and occlusion such as non-breathable footwear increase the susceptibility to infection (Prescott, et al. 1999:814). The infection can become chronic in people who are more susceptible such as patients who are immuno-suppressed or those who have Diabetes mellitus (al Hassan, et al.
2004: 1).
The aim of this placebo-controlled double-blind study was to evaluate the
effectiveness of a topical naturopathic complex comprising of Allium sativum mother tincture (Ø), Hydrastis canadensis (Ø), Apis mellifica (D3) and Urtica urens (D3) (in an aqueous cream base) in the treatment of Tinea pedis. The complex utilized in this study is regarded as naturopathic because the remedies
comprising the complex were selected for the following reasons:
•Allium sativum and Hydrastis canadensis, each utilized in mother tincture, were selected for their antifungal properties.
•Apis mellifica and Urtica urens, each utilized in D3 potency were selected
because their skin symptomotology most accurately matched the symptoms associated with “Athlete’s foot”. / M
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The efficacy of the homoeopathic similimum in the treatment of irritable bowel syndrome in womenHächler, Geraldine Chantal 12 September 2012 (has links)
M.Tech. / Irritable bowel syndrome (IBS) is a multifactoral disorder of the gastrointestinal tract causing disturbances in gastric motility, resulting in abdominal pain, bloating and abnormal bowel movements. It is defined as a 'disorder of gut function in the absence of structural pathology' (Palmer et a!, 2002). It is the most commonly encountered functional gastrointestinal disorder in the primary and secondary health care system with a prevalence in the general population of five to twenty percent (Bellini et a!, 2005). No definite aetiological factor has been isolated, but factors such as psychological stress, anxiety and depression, certain dietary intolerances, increase in abnormal sensitivity to visceral distension, and hormonal changes in women have been implicated in compounding the symptoms of IBS (Ohman & Simren, 2007). Current treatment regimes include dietary changes and symptomatic relief using allopathic medications, which come with the risk of side-effects and may lead to dependency (University of Maryland Medical Center, 2007). Homoeopathic studies which have addressed the physical symptoms as well as the psychological contributing factors associated with IBS, have recorded favourable results when treating this syndrome (Mathie & Robinson, 2006).The aim of this research was to determine the efficacy of Homoeopathic Similimum treatment in IBS. In order to recruit volunteers, this study was advertised in local newspapers, pharmacies and at the University of Johannesburg's Doornfontein Campus. Volunteers completed the Rome III Criteria evaluation to determine their suitability for this study, with the likelihood of any other bowel pathology having been excluded. Ten suitable female volunteers, ranging in age from twenty to thirty five, were selected having met the inclusion criteria. Over a period of three months, each participant partook in four homoeopathic consultations. The initial consultation involved the completion of the information and consent form, an explanation of the research procedures, general well-being and general symptom rating questionnaires were completed, a full homoeopathic case history was taken, and a physical examination was performed. A baseline of four weeks without treatment followed. Participants were requested to complete daily symptom rating scales and keep a daily food diary in the four weeks between consultations. This was continued throughout the study period. The subsequent follow-ups, of which there were three, consisted of a follow-up on the initial consultation, completion of general well-being and symptom rating questionnaire, and a physical examination. A homoeopathic similimum remedy was chosen based on each participant's unique symptoms. Using physical, mental, and emotional symptoms in accordance with classical homoeopathic principles, a single remedy that most suited the individual was chosen and prescribed. It was predicted that the study would provide an alternative and safe treatment option to relieve the symptoms ofiBS. The results of the study showed that the homoeopathic similimum remedy does not provide a statistically significant improvement in the symptoms of IBS. Clinically, however, most participants experienced a general trend of improvement in physical symptoms and general well-being .
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