The purpose of this study is to explore the relationship on career self-efficacy and career satisfaction for human resource practitioners in Taiwan. Besides, this research also explores the moderating effects of of mentoring support and interpersonal trust. One hundred and forty three surveys were received by employees of Taiwanese companies. The data was analyzed by factor analysis, reliability analysis, using the SPSS to measure the relationship amongst the constructs, and we draw some research conclusions as follows. 1. The career self-efficacy of human resource practitioners is significant and positive related to career satisfaction. 2. Though hierarchical regression analysis, the results reveal that Mentoring Support is a moderator of career self-efficacy and career satisfaction. 3. Interpersonal trust has significant and positive influence on between career self-efficacy and career satisfaction.