The thesis disserts an outlook on life and Art of the Modern Indian painter M.F. Husain (1915-2011), with a special attention on his art production which reflects some of socio- cultural changes of modernizing and globalizing India of the 20th and 21th Century. The thesis has been structured in chapters dealing with Husain's personal and artistic development, providing also the analysis of some concrete art works which have been involved with the socio-cultural changes being described - from the point of view of their inner message, formal idiom or the way they have or have not been accepted by the public. The culturological paradigm has been chosen as an appropriate one to treat the topic with aim to integrate systematically various notions of the Humanities. With this goal the author of the thesis uses proper bibliographic, biographic and media references, sources from the Prague's National Gallery's Archive as well as the memoirs of the people who came together with Husain's personality and Art in the time of his visits to ex Czechoslovakia. The thesis is also a kind of deepening and specification of the two of previous bachelor theses of the author (The Modern Art in India - an outline of development, 2010 and The Indian Painting - a History of Cultural Dialogues, 2012).