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Application de la radio enzymologie à l'exploration du métabolisme normal et pathologique des hydroxyindoles en biochimie clinique.Tabuteau, François, January 1900 (has links)
Th.--Pharm.--Paris 5, 1982. N°: 77.
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Voltametrické a amperometrické stanovení homovanilové, vanilmandlové a 5-hydroxy-3-indoloctové kyseliny / Voltammetric and amperometric determination of homovanillic, vanillylmandelic, and 5-hydroxyindole-3-acetic acidNěmečková, Anna January 2020 (has links)
Presented dissertation thesis is focused on the development of electrochemical methods for the determination of three important tumour biomarkers, namely homovanillic acid (HVA), vanillylmandelic acid (VMA), and 5-hydroxyindole-3-acetic acid (5-HIAA). First part of the study is focused on electrochemical behaviour of these analytes in batch arrangement using differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). It has been proved that presented method is sufficiently sensitive for monitoring above mentioned analytes. Moreover, it can be used for determination of HVA and VMA in mixture. Obtained limits of detection (LODs) were 0.24 µmol·L-1 for HVA, 0.06 µmol·L-1 for VMA, and 0.12 µmol·L-1 for 5-HIAA. The requirements to speed up the analysis and at the same time to reduce its price initialized our study of the determination of tested biomarkers in flow systems. Firstly, flow injection analysis with amperometric detection was investigated for the determination of all three biomarkers at the same SPCE, and then an analogous determination of structural more similar pair, HVA and VMA, was performed at a boron doped diamond electrode (BDDE). Obtained LODs of optimized methods were as follows: at SPCE 0.07 µmol·L-1 for HVA, 0.05 µmol·L-1 for VMA, and 0.03 µmol·L-1 for 5-HIAA,...
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