The purpose of this investigation was to study the ultrastructure of the mature cysticercoid of gymenolepis diminuta with special emphasis on the parenchyma. Cysticercoids were dissected from Tribolium confusum, fixed in glutaraldehyde- osmium tetroxide, dehydrated in ethanol and embedded in epon. Thin sections between 250-300 A in thickness were stained with uranyl acetate and lead citrate and observed on a Philips lOOC electron microscope. The photomicrographs revealed that the parenchyma is composed largely of macrocells with very distinct membranes, nuclei and nucleoli. Microcells were also present in the parenchyma. These cells were connected with the cuticle by protoplasmic extensions. The scolex contained f ibroua structures that made up most of the suckers. The suckers showed muscle strands as rays extending outward toward the sucker matrix. The study further showed that circular and longitudinal muscles are found in the scolex and periphery of the cysticercoid. It was observed that the cysticercoids are covered with projections called microtriches. The proximal portion of the microthrix was medullated but not as distinct as in the adult worm and is continuous with the cuticular matrix. The distal portion oi the microthrix was an unmedullated, tapered structure. Mitochondria were present in the cuticle, subcuticle and in the macrocell periphery. Pore canals were also present throughout the parenchyma and strobila.

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Thesis (M. Sc.)--York University, 2002. Graduate Programme in Biology. / Title on thesis acceptance page : Molecular cloning of an [alpha]-tubulin from the Cestode, Hymenolepis, diminuta. Includes bibliographical references (leaves 110-125). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pMQ71611.

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Malic enzyme from the rat tapeworm, Hymenolepis diminuta, has been purified 320-fold to a final specific activity of 29.4. The purification procedure included heat treatment, followed by column chromatography with Sephadex G-20, two phosphocellulose columns, and Sephadex G-200, respectively. The final purified enzyme appeared to be homogeneous on disc gel electrophoresis and G-200 gel filtration.

Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xii, 137 p.; also includes graphics. Includes abstract and vita. Advisors: Jerry F. Downhower and Peter W. Pappas, Dept. of Evolution, Ecology, and Organismal Biology. Includes bibliographical references (p. 128-137).

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Thesis (M.Sc.)--York University, 2004. Graduate Programme in Biology. / Typescript. Includes bibliographical references (leaves 59-66). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss &rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR11754

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Andrea Krejzová Supervisor: PharmDr. Ivan Vokřál, Ph.D. Title of diploma thesis: Effect of albendazole on the activity of selected enzymes in tapeworm Hymenolepis diminuta The efficacy of anthelmintics used to treat diseases caused by helminths is not always sufficient, and in some cases, we are directly facing resistance to these drugs. Helminths, including tapeworms, are able to defend against the toxic effect of anthelmintics using several mechanisms. Xenobiotic metabolizing enzymes and transport proteins belong to these mechanisms. When xenobiotic metabolizing enzymes are induced, the efficacy of therapy may be significantly reduced. The effect of xenobiotic metabolizing enzymes on the drug resistance development has been already described in number of helminths. In tapeworms this information is still missing. Main aim of this study was to determine effect of drug albendazole on the activity of selected xenobiotic metabolizing enzymes in rat tapeworm (Hymenolepis diminuta). Tapeworms were incubated with albendazole (1 μM and 10 μM) for 24 hours. Then activities of selected enzymes in cytosol-like, microsome-like and mitochondria-like fractions were determined. This study is focused on...