A sign pattern is a matrix whose entries are from the set $\{+, -, 0\}$. This thesis contains problems about refined inertias and minimum ranks of sign patterns. The refined inertia of a square real matrix $B$, denoted $\ri(B)$, is the ordered $4$-tuple $(n_+(B), \ n_-(B), \ n_z(B), \ 2n_p(B))$, where $n_+(B)$ (resp., $n_-(B)$) is the number of eigenvalues of $B$ with positive (resp., negative) real part, $n_z(B)$ is the number of zero eigenvalues of $B$, and $2n_p(B)$ is the number of pure imaginary eigenvalues of $B$. The minimum rank (resp., rational minimum rank) of a sign pattern matrix $\cal A$ is the minimum of the ranks of the real (resp., rational) matrices whose entries have signs equal to the corresponding entries of $\cal A$. First, we identify all minimal critical sets of inertias and refined inertias for full sign patterns of order 3. Then we characterize the star sign patterns of order $n\ge 5$ that require the set of refined inertias $\mathbb{H}_n=\{(0, n, 0, 0), (0, n-2, 0, 2), (2, n-2, 0, 0)\}$, which is an important set for the onset of Hopf bifurcation in dynamical systems. Finally, we establish a direct connection between condensed $m \times n $ sign patterns and zero-nonzero patterns with minimum rank $r$ and $m$ point-$n$ hyperplane configurations in ${\mathbb R}^{r-1}$. Some results about the rational realizability of the minimum ranks of sign patterns or zero-nonzero patterns are obtained.