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Synthesis, purification and micronisation of copper indomethacin using dense gas technology /Warwick, Barry. January 2001 (has links)
Thesis (Ph. D.)--University of New South Wales, 2001. / Also available online.
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Effects of intravenous indomethacin during acute ureteral obstruction experimental studies and studies in patients with pain due to ureteral stone obstruction /Sjödin, Jan-Gunnar. January 1981 (has links)
Thesis--Umeå University, Sweden. / Also published as Umeå University Medical dissertations, ISSN 0346-6612 ; new ser. no. 75.
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The polymerisation state of sodium hyaluronate and the in vivo and in vitro influence of indomethacinRoberts, A. A. January 1987 (has links)
No description available.
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Synthesis, purification and micronisation of copper indomethacin using dense gas technologyWarwick, Barry, School of Chemical Engineering & Industrial Chemistry, UNSW January 2001 (has links)
The primary aim of this work was to provide an alternative method of synthesis of the non-steroidal anti-inflammatory drug copper indomethacin (Cu-Indo) and to produce alternative forms of the drug to increase its marketability. Dense gases as anti-solvents were used to achieve these aims. The study involved the synthesis, purification, micronisation and co-precipitation of Cu-Indo with polyvinylpyrrolidone (PVP) using dense carbon dioxide as an anti-solvent. Initially the volumetric and solubility behaviours of the solvent???anti-solvent systems were investigated to determine the optimum processing conditions. The solubility of Cu-Indo in an expanded solution was found to be a complex function of the solvent and other solutes. Copper indomethacin was successfully synthesised and purified in a single vessel using dense carbon dioxide as an anti-solvent. Drug yields of 98 % and purities near 100 % were achieved at optimum conditions with the advantages of less residual solvent in the drug, less solvent waste, reduced processing time and increased yields over the conventional synthesis process. Copper indomethacin was produced in a variety of morphologies and particle sizes using dense carbon dioxide as an anti-solvent. An investigation of the effect of process parameters on the particle characteristics showed that solute concentration was the dominant variable. Spherical particles with diameters less than 8 mm were obtained at optimum conditions. The immediate benefit of micronising Cu-Indo was demonstrated with an eight fold increase in dissolution rate when compared to the conventionally produced drug. Polyvinylpyrrolidone was successfully co-precipitated with Cu-Indo using dense carbon dioxide as an anti-solvent. The PVP???Cu-Indo co-precipitates were found to increase the solubility of the drug in ethanol with a 36 fold solubility enhancement at optimum conditions. The use of dense carbon dioxide as anti-solvent in this work demonstrates the potential of the GAS and ASES processes in the pharmaceutical industry. Copper indomethacin was synthesised, purified and micronised in a single vessel at a substantial saving in terms of time and solvent usage. The micronisation of Cu-Indo and the formation of the PVP???Cu-Indo co-precipitate provided alternative forms of the drug substantially increasing its marketability.
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Anti-inflammatory and phytochemical studies of a Kenyan traditional medicinal plant, Commiphora kuaBattu, Ganga Rao January 2001 (has links)
No description available.
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Synthesis, purification and micronisation of copper indomethacin using dense gas technologyWarwick, Barry, School of Chemical Engineering & Industrial Chemistry, UNSW January 2001 (has links)
The primary aim of this work was to provide an alternative method of synthesis of the non-steroidal anti-inflammatory drug copper indomethacin (Cu-Indo) and to produce alternative forms of the drug to increase its marketability. Dense gases as anti-solvents were used to achieve these aims. The study involved the synthesis, purification, micronisation and co-precipitation of Cu-Indo with polyvinylpyrrolidone (PVP) using dense carbon dioxide as an anti-solvent. Initially the volumetric and solubility behaviours of the solvent???anti-solvent systems were investigated to determine the optimum processing conditions. The solubility of Cu-Indo in an expanded solution was found to be a complex function of the solvent and other solutes. Copper indomethacin was successfully synthesised and purified in a single vessel using dense carbon dioxide as an anti-solvent. Drug yields of 98 % and purities near 100 % were achieved at optimum conditions with the advantages of less residual solvent in the drug, less solvent waste, reduced processing time and increased yields over the conventional synthesis process. Copper indomethacin was produced in a variety of morphologies and particle sizes using dense carbon dioxide as an anti-solvent. An investigation of the effect of process parameters on the particle characteristics showed that solute concentration was the dominant variable. Spherical particles with diameters less than 8 mm were obtained at optimum conditions. The immediate benefit of micronising Cu-Indo was demonstrated with an eight fold increase in dissolution rate when compared to the conventionally produced drug. Polyvinylpyrrolidone was successfully co-precipitated with Cu-Indo using dense carbon dioxide as an anti-solvent. The PVP???Cu-Indo co-precipitates were found to increase the solubility of the drug in ethanol with a 36 fold solubility enhancement at optimum conditions. The use of dense carbon dioxide as anti-solvent in this work demonstrates the potential of the GAS and ASES processes in the pharmaceutical industry. Copper indomethacin was synthesised, purified and micronised in a single vessel at a substantial saving in terms of time and solvent usage. The micronisation of Cu-Indo and the formation of the PVP???Cu-Indo co-precipitate provided alternative forms of the drug substantially increasing its marketability.
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Computational anaylsis of cyclooxygenase inhibition energetics and dynamics /Moth, Christopher Williams. January 2008 (has links)
Thesis (Ph. D. in Chemistry)--Vanderbilt University, May 2008. / Title from title screen. Includes bibliographical references.
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Evaluation of hot-melt extrusion technology to improve dissolution rates of poorly water soluble drugs /Chokshi, Rina. January 2004 (has links)
Thesis (Ph. D.)--University of Rhode Island, 2004. / Typescript. Includes bibliographical references (leaves 177-188).
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Clinical implications of indomethacin superfused over the capillaries of frogs with activated white blood cellsPriebe, Milissa Ann. January 2010 (has links) (PDF)
Thesis (M Nursing)--Montana State University--Bozeman, 2010. / Typescript. Chairperson, Graduate Committee: Elizabeth S. Kinion. Includes bibliographical references (leaves 50-58).
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Mechanical stimulation of bone formation in the ratLean, Jennifer Maree January 1998 (has links)
No description available.
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