Diabetes Mellitus is a group of diseases, prevalence and incidence of which is on the rise not only in the Czech Republic, but also worldwide. This diploma work aims to analyze market situation and opportunities for modern oral anti-diabetic drugs. This work also designs suitable positioning for new OADs of Novartis -- Galvus and Eucreas.

Tobacco use is closely related to changes in body weight. Undesired weight gain following smoking cessation occurs in most patients. The mechanism responsible for changes in body weight post cessation are only partially understood. Several hypotheses have suggested a temporary increase in blood pressure following smoking cessation. In addition, weight concerns after quitting are common, and may affect tobacco dependence treatment outcomes. The aim of our study was to monitor changes in body weight, blood pressure, incretins and selected hormonal parameters among ex-smokers after three months of abstinence. We also examined factors associated with smoking-related weight concerns. We monitored and evaluated selected parameters (personal history, questionnaires, anthropometric, biochemical, hormonal) and compared before and after tobacco dependece treatment, if patients underwent such treatment. We found that smoking cessation was associated with weight gain. Smokers who were more tobacco dependent or more sedentary were at increased risk. The prevalence of diagnosis hypertension did not differ among non-smokers, former smokers and smokers adjusting for age and BMI. In the pilot phase of our study we demonstrated that three months of smoking abstinence was associated with an increase in serum leptin...