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Identifizierung und Charakterisierung von VLIG-1, einer neuen Interferon-induzierten GTPaseKlamp, Thorsten. January 2002 (has links) (PDF)
Köln, Universiẗat, Diss., 2002.
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Viral interferon antagonists and antiviral drugs /Nobre, Rita Luisa Valentim de Avelar. January 2009 (has links)
Thesis (M.Phil.) - University of St Andrews, November 2009.
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The regulation of interferon regulatory factor-1 in raw 264.7 murine macrophages and human umbilical vein endolethial cellsLiu, Li January 2001 (has links)
No description available.
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Hybrid molecules of human interferon and human immunoglobulins : synthesis, purification and characterization.Fung, Kwok-pui, January 1978 (has links)
Thesis--Ph. D., University of Hong Kong, 1978.
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Hybrid molecules of human interferon and human immunoglobulins: synthesis, purification andcharacterization.Fung, Kwok-pui, 馮國培 January 1978 (has links)
published_or_final_version / Microbiology / Doctoral / Doctor of Philosophy
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STUDIES ON THE INTERACTION OF LYMPHOCYTES WITH POLYRIBOINOSINIC: POLYRIBOCYTIDYLIC ACID; LYMPHOCYTE ACTIVATION AND INTERFERON PRODUCTIONDean, Jack H. January 1972 (has links)
No description available.
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Role of the Vaccinia Virus E3 protein and its poxvirus orthologues in suppressing innate immune responses activated by RNA-based pathogen-associated molecular patternsMyskiw, Chad 07 1900 (has links)
Poxviruses are a diverse family of double-stranded DNA viruses. A characteristic feature of poxviruses is that they express a vast array of immuno-modulatory proteins. Vaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola virus, the causative agent of smallpox. The vaccinia E3 protein is required for virus replication in vivo and in numerous cell culture systems. Although E3 function has received considerable study, many aspects of E3 biology remain to be addressed. While E3 can inhibit cytokine expression, the pathways targeted by E3 to block cytokine expression have not been identified. Furthermore, the factor(s) which stimulate innate immune responses during vaccinia infection are not known. In this study, E3 was found to target PKR and RIG-I-like receptor mediated signal transduction to differentially block expression of IFN-β, TNF-α and IL-6 in HeLa cells. RNA species generated in vaccinia infected cells were identified as pathogen-associated molecular patterns capable of inducing cytokine expression and activating apoptosis. Furthermore, PKR, RIG-I and MDA5 play non-overlapping and essential roles in mediating the innate immune response to these RNA species.
Orthologues of E3 are encoded by all poxviruses which infect vertebrate animals except the Avipoxviruses and molluscum contagiosum virus. However, orthologues of vaccinia E3 remain essentially uncharacterized. A comparative analysis of the ability of E3 orthologues encoded by sheeppox, yaba monkey tumour, swinepox and myxoma virus to complement deletion of E3 was performed. E3 orthologues of myxoma virus and swinepox virus suppress PKR activation and interferon induced antiviral activity and restore the host range function of E3 in culture. In contrast, the E3 orthologues of sheeppox virus and yaba monkey tumour virus are unable to inhibit PKR activation. While the sheeppox orthologue cannot restore the host range function of E3, the yaba monkey tumour virus orthologue partially restores E3 deficient vaccinia replication. However, none of these E3 orthologues restore pathogenicity to E3 deficient vaccinia in vivo. In summary, these results highlight the role of the vaccinia virus E3 protein and its poxvirus orthologues in suppressing innate immune responses activated by RNA-based pathogen-associated molecular patterns
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Role of the Vaccinia Virus E3 protein and its poxvirus orthologues in suppressing innate immune responses activated by RNA-based pathogen-associated molecular patternsMyskiw, Chad 07 1900 (has links)
Poxviruses are a diverse family of double-stranded DNA viruses. A characteristic feature of poxviruses is that they express a vast array of immuno-modulatory proteins. Vaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola virus, the causative agent of smallpox. The vaccinia E3 protein is required for virus replication in vivo and in numerous cell culture systems. Although E3 function has received considerable study, many aspects of E3 biology remain to be addressed. While E3 can inhibit cytokine expression, the pathways targeted by E3 to block cytokine expression have not been identified. Furthermore, the factor(s) which stimulate innate immune responses during vaccinia infection are not known. In this study, E3 was found to target PKR and RIG-I-like receptor mediated signal transduction to differentially block expression of IFN-β, TNF-α and IL-6 in HeLa cells. RNA species generated in vaccinia infected cells were identified as pathogen-associated molecular patterns capable of inducing cytokine expression and activating apoptosis. Furthermore, PKR, RIG-I and MDA5 play non-overlapping and essential roles in mediating the innate immune response to these RNA species.
Orthologues of E3 are encoded by all poxviruses which infect vertebrate animals except the Avipoxviruses and molluscum contagiosum virus. However, orthologues of vaccinia E3 remain essentially uncharacterized. A comparative analysis of the ability of E3 orthologues encoded by sheeppox, yaba monkey tumour, swinepox and myxoma virus to complement deletion of E3 was performed. E3 orthologues of myxoma virus and swinepox virus suppress PKR activation and interferon induced antiviral activity and restore the host range function of E3 in culture. In contrast, the E3 orthologues of sheeppox virus and yaba monkey tumour virus are unable to inhibit PKR activation. While the sheeppox orthologue cannot restore the host range function of E3, the yaba monkey tumour virus orthologue partially restores E3 deficient vaccinia replication. However, none of these E3 orthologues restore pathogenicity to E3 deficient vaccinia in vivo. In summary, these results highlight the role of the vaccinia virus E3 protein and its poxvirus orthologues in suppressing innate immune responses activated by RNA-based pathogen-associated molecular patterns
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Weitere Anreicherung von teilweise gereinigtem Fibroblasten-InterferonWojatschek, Claudia, January 1983 (has links)
Thesis (doctoral)--Tübingen, 1983.
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The role of glycogen synthase kinase 3-beta in interferon beta biology /Wang, Huizhi, January 2009 (has links) (PDF)
Thesis (Ph. D.)--University of Louisville, 2009. / Department of Microbiology and Immunology. Vita. "May 2009." Includes bibliographical references (leaves 64-76).
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