My study focuses on methods of the human resources management in an information company. Human resources management and personal information systems present nowadays a very important aspect not only in terms of a management but also in terms of long-term company strategies. Proper human resources management and information system functioning provide an organization with a priceless competitive advantage in the form of effective usage of human resources. At first, human resources management is examined from the theoretic point of view and after that these theoretical needs are set against possibilities of a usage of personal information systems. Consequently, different functions of personal information systems and their supply on the Czech market are analyzed. In the separate chapter I bring in a practical example which summarizes the present state of human resources management and personal information systems in the Tyllco s.r.o. company and which also comprises my recommendation for an improvement.