Reducing groundwater withdrawals from the Mississippi River Valley Alluvial Aquifer is imperative to sustain future irrigated cropping systems in the mid-southern USA. This research was conducted to determine the impacts of cover crops and irrigation sensor thresholds on corn (Zea mays L.) and soybean (Glycine max L.) production, water productivity, irrigation water use efficiency, and soil physical properties in the Mississippi Delta. The cover crop treatments included cereal rye (Secale cereale L.), hairy vetch (Vicia villosa R.), wheat (Triticum aestivum L.)-radish (Raphanus sativus L.)-turnip (Brassica rapa L.) mix, and no cover crop. The irrigation thresholds included -40 kPa, -90 kPa, and no irrigation. In 2020, cover crops and irrigation thresholds showed minimal impacts on most of the measured parameters but showed improvements as the study progressed. After two years, it was determined that long-term evaluations are needed to make a recommendation to producers in the mid-southern USA.