Thesis (Ph. D.)--University of Texas at Austin, 1999. / Vita. Includes bibliographical references (leaves 120-131). Available also in a digital version from Dissertation Abstracts.

A portion of northern southeastern Alaska known as the Juneau gold belt is composed of a disparate assemblage of lithotectonic terranes which range in age from Paleozoic and perhaps older to Cretaceous. Five progressive deformational events associated with contractional tectonism began in the mid-Cretaceous time and continued well into the Tertiary. Widespread plutonism occurred in the region from Cretaceous through Tertiary time. Gold-bearing quartz vein systems in the Juneau gold belt formed within a 160-km-long by 5- to 8-km-wide zone along the western margin of the Coast Mountains, Alaska. The vein systems are localized in second and third order shear zones spatially associated with terrane-bounding, mid-Cretaceous thrust faults. Mesoscopic structures integrated with ⁴⁰Ar/ ³⁹Ar ages from vein sericite are interpreted to indicate that a fluid cycling event along the entire belt occurred between 56.5 and >52.8 Ma. Structural analysis of the vein orientations and geometries are interpreted to indicate that mineralization developed under a near-field stress regime of subhorizontal contraction along a west-southwest to east-northeast trending axis. The axis of extension plunged steeply to the southeast. Slight variations in the interpreted stress axes may have been the result of variations in fluid pressure. Post-mineralization deformation was associated with a dextral transpressive regime along the Denali-Chatham Strait fault system. Gold vein mineralization occurred during the latter stages of orogenesis. Fluid flow and subsequent vein development was temporally associated with changes in plate motion during Eocene time. Veining was also synchronous with exhumation and voluminous plutonism immediately inboard of the gold belt. These interacting tectonic events likely facilitated fault-valve action and vein development along now exhumed shear zones.

Thesis (M.S.)--Oregon State University, 2009. / Printout. Includes bibliographical references (leaves 102-106). Also available on the World Wide Web.

No description available.

Thesis (Professional Degree)--University of Missouri, School of Mines and Metallurgy, 1938. / Leaf number 26 was duplicated, constituting leaves number 26 and 26 1/2. The entire thesis text is included in file. Typescript. Title from title screen of thesis/dissertation PDF file (viewed April 27, 2010)

The purpose of this thesis is to investigate the physical requirements of a building suitable for the future needs of the State Government of Alaska; and to design a building which will be both adequate and appropriate for the state capitol. The writer, in order to produce a more meaningful thesis, made a personal investigation of the site. He spent a period of three months in Juneau, Alaska doing research and generally familiarizing himself with all aspects of the problem. The present congested character of the site makes it of paramount importance to provide as much open space as possible around the capitol group in order to let it be seen to best advantage. Attractively landscaped, the plazas at the base of the government buildings fulfill an important aesthetic function by providing a setting for the buildings. On the capitol site, several related plazas are developed with contrasting architectural masses. The contrast between the vertical office building and the horizontal Capitol creates a striking architectural composition. The balance between these two elements, gives the true impression of an underlying relationship of functional importance and symbolic significance. Taking advantage of the differences in the heights of the plazas, the development provides as much space as is practical for parking, trucking, and other service needs. The principle has been maintained that those people working daily at the capitol must have the benefit of sun and natural light, and a feeling of free space and verdure. Therefore, a skyscraper has been designed for the bureaucracy of the state. This building is designed to allow a flexible pattern of interior areas, which may be easily and economically rearranged to suit changing needs. Similarly, while the main building masses will determine the composition and use of the land area, much of the space can be kept free for future construction that may be in harmony with the pattern already laid down. Placed within the plazas the capitol buildings achieve their proper architectural importance. One hopes, therefore, that there may develop, as an extension of the city’s planning program, an urban environment of park, waterscape, and residences, a unit properly related to the state government buildings, and one which will create an effective setting for the capitol. There is a unique opportunity for creating a civic center, and for an urban reorganization of important parts of the city in tune with the hopes which are held by the farsighted men who have the development of Juneau, Capital of Alaska, in their hands. / Master of Science

Thesis (M.S.)--University of Wisconsin, 1967. / Extension Repository Collection. Typescript (carbon copy). Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 84-85).

Swine barn air is a heterogeneous mixture of dust, bacteria and irritant chemicals including ammonia and hydrogen sulphide. Gram-negative bacteria are commonly found in swine barn air and significantly contribute to pulmonary disease in unprotected swine barn workers, through the endotoxin moiety, lipopolysaccharide (LPS). Toll-like Receptor-4 is the ligand for LPS. It is found on many cell types including monocytes, macrophages, neutrophils, endothelial cells, and to a lesser extent, epithelial cells. The severity and outcome of acute lung injury following barn air exposures depends upon the balance between epithelial and vascular endothelial repair mechanisms, including angiogenesis. Vascular Endothelial Growth Factor (VEGF) is an endothelial mitogen produced by mesenchymal and alveolar Type II epithelial cells and by activated bronchial airway epithelial cells. Research investigating the role of cytokines in angiogenesis has shown that close proximity of immune cells and endothelial cells modulates the production of various compounds that regulate vascular function. Given that LPS is the ligand for TLR4 there appeared to be a role for TLR4 in angiogenesis, particularly following endotoxin exposure. To determine whether this was occurring, we examined whether exposure to swine barn air alters vascular density in the lungs and the role of TLR4 using a murine model. Toll-like Receptor-4 wild-type (C3HeB/FeJ) and TLR4 mutant (C3H/HeJ) mice were obtained and exposed to swine barn air for 1-, 5-, or 20-days for 8 hours/day. Wild-type animals showed a 127% increase in vascular density after 20-days barn air exposure. Vascular Endothelial Growth Factor-A protein levels were decreased by 0.62-fold after one-day swine barn air exposure in wild-type animals, indicating that VEGF-A is being used as a pro-angiogenic mitogen. Transcription of VEGF-A mRNA was increased in wild-type animals after all swine barn air exposure periods. The receptor VEGFR-1 showed increased mRNA transcription over all time points. These effects were only observed in TLR4 wild-type animals, indicating that these effects are mediated by TLR4. Further, VEGF-A and VEGFR-1 appear to be involved in the manifestation of TLR4-induced angiogenesis in the lung.

Swine barn air is a heterogeneous mixture of dust, bacteria and irritant chemicals including ammonia and hydrogen sulphide. Gram-negative bacteria are commonly found in swine barn air and significantly contribute to pulmonary disease in unprotected swine barn workers, through the endotoxin moiety, lipopolysaccharide (LPS). Toll-like Receptor-4 is the ligand for LPS. It is found on many cell types including monocytes, macrophages, neutrophils, endothelial cells, and to a lesser extent, epithelial cells. The severity and outcome of acute lung injury following barn air exposures depends upon the balance between epithelial and vascular endothelial repair mechanisms, including angiogenesis. Vascular Endothelial Growth Factor (VEGF) is an endothelial mitogen produced by mesenchymal and alveolar Type II epithelial cells and by activated bronchial airway epithelial cells. Research investigating the role of cytokines in angiogenesis has shown that close proximity of immune cells and endothelial cells modulates the production of various compounds that regulate vascular function. Given that LPS is the ligand for TLR4 there appeared to be a role for TLR4 in angiogenesis, particularly following endotoxin exposure. To determine whether this was occurring, we examined whether exposure to swine barn air alters vascular density in the lungs and the role of TLR4 using a murine model. Toll-like Receptor-4 wild-type (C3HeB/FeJ) and TLR4 mutant (C3H/HeJ) mice were obtained and exposed to swine barn air for 1-, 5-, or 20-days for 8 hours/day. Wild-type animals showed a 127% increase in vascular density after 20-days barn air exposure. Vascular Endothelial Growth Factor-A protein levels were decreased by 0.62-fold after one-day swine barn air exposure in wild-type animals, indicating that VEGF-A is being used as a pro-angiogenic mitogen. Transcription of VEGF-A mRNA was increased in wild-type animals after all swine barn air exposure periods. The receptor VEGFR-1 showed increased mRNA transcription over all time points. These effects were only observed in TLR4 wild-type animals, indicating that these effects are mediated by TLR4. Further, VEGF-A and VEGFR-1 appear to be involved in the manifestation of TLR4-induced angiogenesis in the lung.