Audience responese technology (ART) often called clickers are becoming more common, not only internationally but also at Swedish universities. No direct Swedish research has been identified, this is however a major area of research internationally. There is both research on clickers positive effect on study results and how students feel about using clickers. This study has taken a Swedish translated version of Cheesman, Winograd, and Wehrman’s (2010) survey to investigate how perception of clickers differ between students in Disciplinary Domain of Medicine and Pharmacy and Disciplinary Domain of Science and Technology. 166 unique students, 48 students at the disciplinary domain of medicine and pharmacy, and 118 students in the disciplinary domain of science and technology has responded. It is possible to find significant differences in students perception in all four factors examined between students at the various disciplinary domains. Students at the disciplinary domain of medicine and pharmacy were more positive to both the factor ‘feedback and understanding’ and the factor ‘anonymity’, and they were less negative to the factor ‘points’. The students at the disciplinary domain of science and technology were more positive to the factor ‘peer discussions’. When it comes to sex, you can not ensure any significant differences between males and females. There were also large differences between the results of this study and Cheesman, Winograd, and Wehrman’s (2010) study. This suggests that a student's disciplinary domain or culture is vital to the student's attitude toward clickers.