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1	Strong Antibiotic Activity of the Myxocoumarin Scaffold in vitro and in vivo Hertrampf, Gesa, Kusserow, Kalina, Vojnovic, Sandra, Pavic, Aleksandar, Müller, Jonas I., Nikodinovic-Runic, Jasmina, Gulder, Tobias A. M. 16 May 2024 (has links) The increasing emergence of resistances against established antibiotics is a substantial threat to human health. The discovery of new compounds with potent antibiotic activity is thus of utmost importance. Within this work, we identify strong antibiotic activity of the natural product myxocoumarin B from Stigmatella aurantiaca MYX-030 against a range of clinically relevant bacterial pathogens, including clinical isolates of MRSA. A focused library of structural analogs was synthesized to explore initial structure-activity relationships and to identify equipotent myxocoumarin derivatives devoid of the natural nitro substituent to significantly streamline synthetic access. The cytotoxicity of the myxocoumarins as well as their potential to cure bacterial infections in vivo was established using a zebrafish model system. Our results reveal the exceptional antibiotic activity of the myxocoumarin scaffold and hence its potential for the development of novel antibiotics. info:eu-repo/classification/ddc/540 ddc:540 info:eu-repo/classification/ddc/660 ddc:660
2	Genetic diversity in sesame (Sesamum indicum L.): molecular markers, metabolic profiles and effect of plant extracts on soil-borne pathogenic fungi / Genetische Diversität in Sesam (Sesamum indicum L.): Genomebene, Profile der Sekundärmetabolitenproduktion und Wirkung von Sesam-Extracten auf mikrobielle Krankheitserreger Laurentin, Hernan 25 April 2007 (has links) No description available. 630 Landwirtschaft Veterinärmedizin Agricultural Sciences Sesamum indicum Sesam Genetisher Diversität Profile der Sekundarmetaboliten Pflnazen Extrakten mikrobielle Krankheitserreger Sesamum indicum sesame AFLP genetic diversity metabolic profiles plant extracts metabolites soil-borne pathogenic fungi 48.54 YEK189

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Strong Antibiotic Activity of the Myxocoumarin Scaffold in vitro and in vivo