The presented diploma thesis deals with stress-strain analysis of the intact human knee joint and the knee joint after reconstruction using fixation plate. Finite element method is used to determine the biomechanical response of the knee under loading with the FE software Ansys. The three-dimensional finite element model is consisted of bony structures (femur and tibia) which were created using computed tomography (CT) data, articular cartilages and both menisci. Model of the locking plate (LCP) was created based on producer's technical guide. Three models of the knee joint with LCP fixation plate are created for three different sizes of condylar fragment based on the intact model. On all variants is applied loading corresponding to maximum loading in a gait cycle. The results show that reconstruction of the knee joint with locking plate has no effect on changing in contact pressure on tibial plateau.