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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Copper Toxicity and Accumulation: Physiology, Chemistry, and Molecular Biology

Blanchard, Jonathan 06 August 2009 (has links)
Our knowledge of aquatic Cu toxicity has increased greatly over the past several years culminating with the incorporation of a model (the Biotic Ligand Model (BLM)) into the regulatory framework which allows for the site specific adjustment of water quality criteria based on water chemistry. However, our understanding of Cu toxicity in the aquatic environment is limited mostly to freshwater (FW). Because of this limited knowledge, this dissertation set out to examine the affect of salinity on Cu toxicity and accumulation across salinities from FW to sea water (SW). First, this work examined tissue specific Cu accumulation in five salinities (FW, 5 ppt, 11 ppt, 20 ppt, 28 ppt) from waterborne Cu exposure at two [Cu] (30 and 150 µg Cu L-1) in the euryhaline killifish, Fundulus heteroclitus. Branchial and hepatic accumulation followed a pattern that would be expected based on speciation and competition from cations. [Cu] were high in FW and decreased as salinity increased. However, in the intestine, [Cu] were highest at 5 ppt and were also elevated in the higher salinities. The elevation at the higher salinities was most likely due to drinking by the fish which increases as salinity increases above the isoosmotic point of the fish (~10 ppt) for osmoregulatory purposes and showed a trend toward increasing [Cu] with increasing salinity as would be expected. Secondly, the mechanism of Cu toxicity in FW and SW was examined in killifish. The mechanism of Cu toxicity in the killifish in FW was the same as had been seen for other FW fish. Cu exposure caused a decrease in Na+ / K+ ATPase activity which led to a decrease in whole body [Na+] which is the likely cause of death. In SW, surprisingly no ionoregulatory disturbances were observed. The only measured parameter that was changed in SW was net ammonia which showed a substantial decrease. Therefore, the mechanism of acute copper toxicity in FW and SW differed suggesting that physiology may need to be considered in future development of a BLM for SW. Next, the effect of salinity on Cu accumulation from a naturally incorporated dietary source was examined in FW and SW in Fundulus heteroclitus. Cu accumulation was not seen to differ in the two salinities in spite of differences in gut fluid chemistry that would lead to an ~11 fold difference in free Cu ion between FW and SW. This indicated that Cu accumulation from a dietary source was not as the free ion but most likely as organically (amino acid) bound Cu. In addition to this, subcellular fractionation of the diet revealed that Cu available to the next trophic level did not change with increasing waterborne [Cu], increasing tissue [Cu], or time in oysters which has implications for Cu accumulation in the environment. Finally, the molecular mechanisms behind effects and acclimation to waterborne and dietary Cu exposure in FW and SW were examined using suppression subtraction hybridization in the killifish intestine. Exposure to Cu induced a stress response which could be responsible for upregulation of genes involved in protein synthesis, proteolysis and ATP production. At the tissue level, two main responses were observed. First, genes necessary for muscle function were upregulated potentially in response to previously observed decreased intestinal motility. Secondly, apoptotic genes were upregulated corresponding to increased rates of apoptosis in intestines during dietary exposures. At the cellular level, metal chelators and oxidative stress genes were upregulated in response to increased free Cu in the cell and the subsequent free metal induce free radical formation. This work has advanced our understanding of Cu toxicology in saline environments and emphasized the importance of considering both chemistry and physiology in analyzing and interpreting Cu toxicology especially in saline environments. Hopefully, it will contribute to the future development of Cu water quality criteria.
2

Knowledge, culture, and identity : American influence on the development of library and information science in South Korea since 1945 /

Chang, Durk Hyun, January 2000 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 2000. / Vita. Includes bibliographical references (leaves 200-223). Available also in a digital version from Dissertation Abstracts.
3

Rethinking the Library /

Tong, Tsou-hang, Albert. January 2001 (has links)
Thesis (M. Arch.)--University of Hong Kong, 2001. / Includes bibliographical references.
4

The teaching of library management in United Kingdom Schools of Librarianship

Jones, K. H. January 1977 (has links)
Thesis (M.A.)--University of Bradford (Postgraduate School of Studies in Research in Education). / Includes bibliographical references (p. 115-139).
5

Education for librarianship in Colombia

Krzys, Richard. January 1965 (has links)
Thesis (Ph. D.)--Western Reserve University. / Bibliography: leaves 235-248.
6

Education for librarianship in Southeast Asia: a comparative methodological study.

Furbeyre, Mae Lachica. January 1978 (has links)
Thesis--University of Southern California. / Order no.: 2542C. eContent provider-neutral record in process. Description based on print version record. Bibliography: leaves 377-412.
7

Development of librarianship in South Korea, 1945-1992 a historical study /

Cho, Chansik. January 1995 (has links)
Thesis (Ph. D.)--Rutgers University, 1995. / "UMI number: 9524172." Includes vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 268-278).
8

The teaching of library management in United Kingdom Schools of Librarianship

Jones, Ken, January 1977 (has links)
Thesis (M.A.)--University of Bradford (Postgraduate School of Studies in Research in Education). / Includes bibliographical references (p. 115-139).
9

Education for librarianship in Southeast Asia: a comparative methodological study.

Furbeyre, Mae Lachica. January 1978 (has links)
Thesis--University of Southern California. / Order no.: 2542C. Bibliography: leaves 377-412.
10

Application of an operational model for library project evaluation

Sheldon, Brooke Earle, January 1977 (has links)
Thesis--University of Pittsburgh. / Includes bibliographical references (leaves 169-174).

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