Over the last few decades, we have been witnessing a tremendous evolution in mobile computing, wireless networking and hand-held devices. In the future communication networks, users are anticipated to become even more mobile demanding for ubiquitous connectivity to different applications which will be preferably aware of their context. Admittedly, location information as part of their context is of paramount importance from both application and network perspectives. From application or user point of view, service provision can upgrade if adaptation to the user's context is enabled. From network point of view, functionalities such as routing, handoff management, resource allocation and others can also benefit if user's location can be tracked or even predicted. Within this context, we focus our attention on indoor localization and handoff prediction which are indispensable components towards the ultimate success of the envisioned pervasive communication era. While outdoor positioning systems have already proven their potential in a wide range of commercial applications, the path towards a successful indoor location system is recognized to be much more difficult, mainly due to the harsh indoor characteristics and requirement for higher accuracy. Similarly, handoff management in the future heterogeneous wireless networks is much more challenging than in traditional homogeneous networks. Handoff schemes must be seamless for meeting strict Quality of Service (QoS) requirements of the future applications and functional despite the diversity of operation features of the different technologies. In addition, handoff decisions should be flexible enough to accommodate user preferences from a wide range of criteria offered by all technologies. The main objective of this thesis is to devise accurate, time and power efficient location and handoff management systems in order to satisfy better context-aware and mobile applications. For indoor localization, the potential of Wireless Local Area Network (WLAN) and Radio Frequency Identification (RFID) technologies as standalone location sensing technologies are first studied by testing several algorithms and metrics in a real experimental testbed or by extensive simulations, while their shortcomings are also identified. Their integration in a common architecture is then proposed in order to combine their key benefits and overcome their limitations. The performance superiority of the synergetic system over the stand alone counterparts is validated via extensive analysis. Regarding the handoff management task, we pinpoint that context awareness can also enhance the network functionality. Consequently, two such schemes which utilize information obtained from localization systems are proposed. The first scheme relies on a RFID tag deployment, alike our RFID positioning architecture, and by following the WLAN scene analysis positioning concept, predicts the next network layer location, i.e. the next point of attachment to the network. The second scheme relies on an integrated RFID and Wireless Sensor/Actuator Network (WSAN) deployment for tracking the users' physical location and subsequently for predicting next their handoff point at both link and network layers. Being independent of the underlying principle wireless access technology, both schemes can be easily implemented in heterogeneous networks. Performance evaluation results demonstrate the advantages of the proposed schemes over the standard protocols regarding prediction accuracy, time latency and energy savings