Yes / This study proposes and tests a model of how and when previous failure experience can impact on subsequent business model innovation of business-to-business (B2B) SMEs. Analysis of survey data from a sample of 182 B2B SMEs in Ghana indicates that failure experience is positively related to business model innovation – and that coopetition capability mediates this failure experience. Further analysis of boundary condition effects reveals that high levels of financial resource slack strengthen the positive relationship between coopetition and business model innovation, while the level of managerial persistence has no effect on failure experience and coopetition relationship. We discuss the theoretical and managerial implications of these findings.