The water and coal samples from the Manisa-Soma-DeniS region were studied on the basis of their basic characteristics, inorganic and organic parameters. Coal samples were determined as low-quality lignite. They have high concentrations of arsenic, uranium and lead. The organics in the coal samples are of aliphatic hydrocarbons and their derivatives (alkanes and alcohols), methyls, phthalates, naphtalenes and benzenes. They are inactive and low in concentrations. Water samples have basic characteristics within the range of drinking waters. They also have high arsenic and uranium concentrations indicating a possible leaching. Their organic compounds are similar to those in the coal samples. However, these organic compounds are not as toxic as those found in endemic samples and their concentration is also very low. Therefore, they are considered not to be a potential for Balkan Endemic Nephropathy (BEN)-disease. On the basis of the findings of this study, the area can be concluded as non-endemic region.