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Optimization theory is a key technology for inverse problems of reconstruction in science, engineering and economy. Discrete tomography is a modern research field dealing with the reconstruction of finite objects in, e.g., VLSI chip design, where this thesis will focus on. In this work, a framework with its supplementary algorithms and a new problem reformulation are introduced to approximately resolve this NP-hard problem. The framework is modular, so that other reconstruction methods, optimization techniques, optimal experimental design methods can be incorporated within. The problem is being revisited with a new optimization formulation, and interpretations of known methods in accordance with the framework are also given. Supplementary algorithms are combined or incorporated to improve the solution or to reduce the cost in terms of time and space from the computational point of view.