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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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The study of the enzymes of the mixed function oxidase¡]MFO¡^system and its relation to the imposex of Thais spp.Yang, Wei-Ching 22 August 2000 (has links)
Induction imposex of gastropod snails by organotins has been reported worldwide. However, the relationship between imposex and detoxification capability is not well studied in molluscs. In the present study, the relationship between the mixed function oxidase (MFO) system and the degree of imposex in drills Thais spp. was investigated. Thais clavigera, T. rufotincta and T. sp. were collected from the west coast of Taiwan. The degree of imposex was determined by percent imposex, relative penis size (RPS) and vas defenes sequence (VDS). Enzymes of cytochrome P450, NADPH-cytochrome c reductase, EROD¡]7-ethoxyresorufin-O-deethylation¡^ and cytochrome P420 (an inactive form of cytochrome P450) in the MFO system were examined. In the three Thais species, the degrees of imposex expressed as percent imposex, RPS and VDS were 71-100%, 8.8-62.5% and 0.7-2.5, respectively. Contents of cytochrome P450 and cytochrome P420 were 0.043-0.097 nmol/mg protein and 0.129-0.296 nmol/mg protein, respectively. The activity of NADPH-cytochrome c reductase was in the range of 1.52-6.73 nmol/min/mg protein. The activity of EROD was not detected. Negative trends between the degree of imposex and the contents of cytochrome P450 and cytochrome P420 were found in all the Thais species. And, a positive trend betweed the degree of imposex and the activity of NADPH-cytochrome c reductase was also observed. Based on the results, it is suggested that the induction of imposex was possibly due to the imbalance of steroid hormone metabolism caused by the inhibition of cytochrome P450 activity.
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X-ray characterization of PaPheOH, a bacterial phenylalanine hydroxylase /Ekström, Fredrik, January 2003 (has links)
Diss. (sammanfattning) Umeå : Univ., 2003. / Härtill 4 uppsatser.
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Studies on warfarin treatment with emphasis on inter-individual variations and drug monitoring /Osman, Abdimajid, January 2007 (has links) (PDF)
Diss. (sammanfattning) Linköping : Linköpings universitet, 2007. / Härtill 4 uppsatser.
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Clinical utility, cost-effectiveness and provider perceptions of CYP2C9 and VKORC1 genotyping for chronic warfarin therapy /Meckley, Lisa M. January 2008 (has links)
Thesis (Ph. D.)--University of Washington, 2008. / Vita. Includes bibliographical references (leaves 91-124).
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A comparative study of cytochromes P450 2E1 and 2A6 : substrate dynamics, multiple ligand binding, and adduct formatioin by N-acetyl-m-aminophenol /Harrelson, John P. January 2005 (has links)
Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 200-205).
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Influence of CYP2C9 and VKORC1 genotypes on warfarin response in African-American and European American patientsLimdi, Nita A. January 2007 (has links) (PDF)
Thesis (Ph.D.)--University of Alabama at Birmingham, 2007. / Title from PDF title page (viewed on Feb. 19, 2010). Includes bibliographical references.
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Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1 /Karlgren, Maria, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 5 uppsatser.
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Hypoxia-inducible factor hydroxylases are oxygen sensors in the brain /Dalgard, Clifton Lee. January 2005 (has links) (PDF)
Thesis (Ph. D.)--Uniformed Services University of the Health Sciences, 2005. / Typescript (photocopy).
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