Au croisement de la sociologie des mobilisations, de la sociologie des migrations et des études genre, cette thèse vise à saisir la réalisation des rapports de domination dans l’action collective des migrant.e.s brésilien.ne.s au Japon dans les années 2000. Au delà des catégorisations ethnoraciales (descendant.e / non descendant.e de Japonais) et classées (ouvrier.ère / indépendant.e), généralement utilisées pour décrire ce fait migratoire, les catégories de sexe contribuent aussi à le caractériser. Dans la perspective de l’intersectionnalité, la thèse s’appuie sur l’ethnographie multisituée pour appréhender la réalisation des rapports sociaux de sexe, de race et de classe. Ceux-ci s’actualisent dans des pratiques circonscrites mais aussi dans des contextes variés où l’intersectionnalité se révèle d’autant mieux que les rapports de pouvoir peuvent changer, s’inverser, « s’invisibiliser ». Pour ce faire, trois espaces de mobilisation ont été explorés : des écoles brésiliennes, des syndicats et des associations locales. Des observations in situ étalées entre 2006 et 2011 ont été complétées par quatre-vingt-dix entretiens semi-directifs en portugais et en japonais avec des familles migrantes, les migrant.e.s mobilisé.e.s, les leaderships et leurs soutiens extérieurs. En examinant leurs interactions, l’enquête multisituée montre que la réalisation des rapports de domination s’appréhende à partir de trois échelles d’analyse : nationale (les contextes japonais et brésilien), sectorielle (syndical, éducatif et associatif) et situationnelle (les dynamiques des organisations dans chaque secteur). De cette façon, la thèse fait ressortir les nouvelles frontières de la société japonaise et les reconfigurations de l’imaginaire national brésilien selon les sites de l’enquête. / At the intersection of the sociology of mobilization, the sociology of migration and the gender studies, this thesis aims at capturing the accomplishment of relations of domination in the collective actions of Brazilian migrants in Japan in the 2000s. Beyond ethnoracial (descendants / non descendants of Japanese people) and class-based (unskilled workers / self-employed) categorizations, generally used to describe this migration, the social relations of sex also help to categorize the phenomenon. In the wake of the theory of intersectionality, this thesis – based on a multisited ethnography – analyzes the production of social relations of sex, race and class. These can be observed in specific practices but also in a variety of contexts where intersectionality becomes all the more noticeable as the relations of power may change, interchangeable and « invisible ». To do so, three spaces of mobilization have been explored : Brazilian schools, workers’ unions and grassroots organizations. In situ observations were conducted from 2006 to 2011 and ninety semi-structured interviews were led in Japanese and Portuguese with migrant families, members and leaderships of the groups, and their external supporters. The multisited field study shows that the accomplishment of the relations of domination can be captured by focusing on three scales of analysis : national (Brazilian and Japanese contexts), sector-based (education, unionism and voluntary sector), situational (organizational dynamics in each sector). In this way, the thesis highlights the new boundaries of Japanese society and the reconfigurations of an imagined Brazilian community depending on the sites studied.

Suite à une ischémie, de nombreux acteurs moléculaires et cellulaires concourent pour promouvoir la revascularisation post-ischémique afin de limiter les lésions tissulaires. Des cellules progénitrices et inflammatoires originaires de la moelle osseuse sont notamment recrutées au niveau du tissu ischémique où elles activent et participent à la régénération vasculaire et tissulaire. Leurs capacités pro-angiogéniques et pro-vasculogéniques suscitent d’ailleurs un grand intérêt pour l’élaboration de nouvelles stratégies thérapeutiques. L’objectif de ce travail de thèse aura été d’améliorer notre compréhension des mécanismes qui régissent la mobilisation et le recrutement des cellules progénitrices originaires de la moelle osseuse et de mettre en évidence l’efficacité d’un traitement basée sur l’utilisation de cellules souches pour promouvoir la revascularisation post-ischémique. Dans un premier travail nous avons mis en évidence que les catécholamines (dopamine -DA- et norépinephrine –NE-) du système nerveux sympathique régulent la mobilisation des cellules progénitrices originaires de la moelle osseuse via une signalisation dépendante de la eNOS. Nous avons montré que la DA et la NE augmentent le nombre de cellules médullaires recrutées dans le tissu ischémique et stimulent leur différenciation en cellules à phénotype endothéliale ou inflammatoire favorisant ainsi la revascularisation post-ischémique. Le recrutement des cellules médullaires dépend également des chimiokines, et plus particulièrement de CXCL12 qui est connue pour attirer les cellules exprimant son récepteur CXCR4. Le deuxième travail de cette thèse a montré que le pouvoir chimioattractant de CXCL12 est également régulé par sa capacité à se lier aux héparan-sulfates (HS), et donc à adhérer à la matrice extracellulaire. En effet, de fortes interactions CXCL12/HS induisent une augmentation de la régénération vasculaire post-ischémique corrélée à un meilleur recrutement des cellules d’origine médullaires dans le tissu lésé.Une fois recrutées dans le tissu ischémique, les cellules souches, de part leurs capacités remarquables d’auto-renouvellement, de prolifération, de différenciation et leur activité paracrine sont d’excellents activateurs de la revascularisation post-ischémique. La troisième étude de cette thèse met en évidence l’efficacité des cellules souches embryonnaires humaines multipotentes pour traiter l’ischémie critique du membre inférieur. Nous avons également révélé que ce potentiel thérapeutique dépend du miR-21.Ces travaux ont permis de démontrer que la régulation de la mobilisation et du recrutement des cellules souches contrôle la revascularisation post-ischémique et de souligner l’efficacité d’un traitement basé sur l’utilisation de cellules souches pour promouvoir la revascularisation post-ischémique. / Following ischemia, many molecular and cellular mechanisms compete to promote post-ischemic revascularization to minimize tissue damage. Bone marrow-derived progenitor and inflammatory cells are especially recruited into the ischemic tissue where they activate and participate in vascular and tissue regeneration. Their pro-angiogenic and pro-vasculogenic capacity also generate great interest in the development of new therapeutic strategies. The objective of this thesis has been to improve our understanding of the mechanisms governing the mobilization and recruitment of bone marrow-derived progenitor cells and to highlight the effectiveness of a treatment based on the use of stem cells to promote post-ischemic reperfusion. In a first work we have demonstrated that catecholamines (dopamine -DA- and norepinephrine -NE-) of the sympathetic nervous system regulate the mobilization of bone marrow-derived progenitor cells via eNOS-dependent signaling. We have shown that DA and NE increase the number of bone marrow-derived cells recruited into the ischemic tissue and stimulate their differentiation into endothelial or inflammatory phenotype cells, which promots post-ischemic revascularization.The recruitment of bone marrow cells also depends on chemokines, and particularly CXCL12 which is known to attract cells expressing CXCR4. The second work of this thesis has shown that the chemoattractant capacity of CXCL12 is also regulated by its ability to bind to heparan sulfate (HS), and thus, to adhere to the extracellular matrix. Indeed, strong interactions between CXCL12 and HS induce an increase in post-ischemic vascular regeneration correlated with better recruitment of bone marrow-derived cells in the injured tissue.Once recruited into the ischemic tissue, stem cells, because of their remarkable capacity of self-renewal, proliferation, differentiation and paracrine activity are excellent activators of post-ischemic revascularization. The third study of this thesis highlights the effectiveness of pluripotent human embryonic stem cells to treat critical limb ischaemia. We also found that their therapeutic potential depends on the miR-21.These studies have demonstrated that the regulation of the mobilization and recruitment of stem cells control the post-ischemic revascularization and highlight the effectiveness of a treatment based on the use of stem cells to promote post-ischemic revascularization.

L'objectif principal de ces travaux de thèse est l'étude expérimentale de la mobilisation de l'huile dans le cadre de la récupération assistée du pétrole à base de tensioactif dans un milieu poreux en deçà de la saturation en huile résiduelle. A saturation en huile résiduelle, le réseau d'huile est déconnecté et constitué de ganglions dans l'ensemble du milieu poreux. Cette huile résiduelle est difficile à produire dans les conditions classiques de récupération du pétrole à cause du piégeage capillaire des ganglions, piégeage corrélé à la tension interfaciale entre l'huile et l'eau. Le déplacement de la solution de tensioactif et sa caractérisation a été réalisé au travers d'injections en milieux poreux naturels. L'étude a été réalisée dans un premier temps en conditions monophasiques, c'est-à-dire en absence d'huile. Les courbes de percée ont été analysées pour étudier les paramètres de dispersivité et d'adsorption des échantillons. Les expériences sont ensuite utilisées pour améliorer la modélisation du transport du tensioactif en milieu poreux. Pour le cas diphasique, nous avons développé un système microfluidique avec une géométrie de pore variable, le plus représentatif possible d'un milieu poreux naturel. Il s'agit dans les expériences d'injecter un petit ganglion d'huile à travers un canal central et de balayer la puce microfluidique avec la solution tensioactive dans des conditions contrôlées. L'objectif est d'étudier le déplacement du ganglion d'huile au sein du micromodèle. De nouveaux mécanismes sont identifiés et une voie de modélisation des phénomènes physique est proposée. / The main objective of the PhD is to study experimentally the oil mobilization using surfactant in a porous media below the residual oil saturation. At the residual oil saturation, the oil network is disconnected and organized in ganglia of different sizes and shapes all along the sample. This residual oil is difficult to produce in the classical conditions of water flooding because of capillary trapping created by the interfacial tension between oil and water. Injection of surfactant is able to mobilize the remaining oil at flow rates consistent with the real case of an oil mature reservoir. The use of surfactant allows lowering the interfacial tension by several orders of magnitude, towards ultra-low values (10-3 mN/m), strongly decreasing the capillary forces and so, mobilizing the oil. The first main study of the PhD work was to characterize the displacement of the surfactant injected in a sandstone sample in monophasic conditions (without oil). Breakthrough curves have been analyzed in term of dispersivity and adsorption. Experiments have shown that a better way to model the surfactant transport is to use a Langmuir kinetic adsorption model. For the diphasic case, we have developed a microfluidic 2D system with a random pore geometry of controlled conditions. The experiments are based on the injection of a small ganglia through a central channel, then, a surfactant flood is generated. The aim is to see how ganglia are displaced within the micromodel. New mechanisms have been identified and a way to model those phenomena has been proposed. A better understanding of surfactant and oil transport in porous media is key for chemical enhanced oil recovery processes.

La production physiologique continue de cellules myélinisantes dans le système nerveux (SN) de mammifère offre de nouvelles perspectives thérapeutiques. Lors d’une atteinte de la myéline, une régénération endogène impliquant la génération d’oligodendrocytes s’engage. Ce processus repose sur la mobilisation de progéniteurs oligodendrocytaires parenchymateux et de progéniteurs de la zone sous-ventriculaire (SVZ). Cette réparation ne permet cependant pas une récupération fonctionnelle systématique. Nos travaux ont pour but d’identifier les facteurs qui contrôlent les différentes étapes de régénération. Ils révèlent une réexpression du CNTF et une surexpression des héparans sulfates protéoglycanes (HSPGs) suite à une démyélinisation du corps calleux. Ces changements de l’environnement péri-lésionnel régulent positivement le processus de remyélinisation. Nous avons montré un impact direct de l’expression post-lésionnelle du CNTF sur la mobilisation des deux sources cellulaires. Différents tests in vitro ont identifié le CNTF comme facteur chémoattractant pour ces cellules. Nos données montrent également que des modifications de sulfatation des héparans sulfates (HS) protéoglycanes contrôlées par la N-désacétylase-Sulfotransférase 1 des cellules du lignage oligodendrocytaire s’établissent en bordure de lésion et créent un microenvironnement favorable à la régénération. Divers test fonctionnels in vivo et in vitro révèlent le rôle clef des HSPGs dans la cinétique de démyélinisation et de remyélinisation en régulant la mobilisation des cellules du lignage oligodendrocytaire et l’activation microgliale. / In the mammal’s nervous system, the ongoing production of new myelinating cells on has open news therapeutic perspectives for demyelinating diseases. An endogenous regeneration process involving the generation of oligodendrocytes can occur following demyelination. This process relies on the mobilization of an endogenous reservoir of progenitor cells located in the adult brain: The parenchymal oligodendrocyte precursors and the subventricular zone derived neural progenitors. However, these endogenous repair attempts do not permit an efficient functional recovery. These failures are mainly due to mobilization, differentiation or to the generation of a hostile environment for the repair process. Our work is focusing on the identification of factors regulating those events. Our data show the reexpression of CNTF and overexpression of heparan sulphate proteoglycans (HSPGs) following a focal demyelination of the corpus callosum in adult mice. These environmental changes favor myelin repair. We show a direct impact of the post-lesional expression of CNTF on the mobilization of both cellular sources. Using various in vitro assays, we showed that CNTF is acting on the two cellular sources as a chemoattractant factor. Our data also show that sulfation modifications of HSPGs performed by the deacetylase-N-sulfotransferase 1 (Ndst1) on oligodendrocyte lineage cells occurred around the lesion and created a permissive microenvironment for the regenerative process. Various in vitro and in vivo functional assays demonstrated the key role of HSPGs in demyelination and remyelination dynamic by controlling mobilization of the oligodendrocyte lineage cells and microglial activation.

The aim of this study is to explore the importance of community based social mobilisation strategies in advancing human rights, in particular, strategies that could be used advance exercise of the right to legal capacity for persons with psychosocial disabilities in the face of societal barriers in the African context. The results of the study are aimed at providing useful and practical considerations in addressing the gap that exist in human rights implementation, between the promises of the law and its impact in reality. To this end, secondary desk top data was collected from existing text on the CRPD, mental illness and social mobilisation strategies. The latter was based on an analysis of the mobilisation strategy employed by Tostan in West Africa to successfully challenge female genital mutilation/cutting. Primary data was obtained through focus groups held in Lusaka and at Nsadzu Mental Health Rehabilitation Centre in Chadiza, in rural Zambia. The significance of legal capacity in Zambia was established and three main categories of concern emerged as barriers to the exercise of legal capacity: a) lack of state and community based supports and social networks; b) inadequate training of health and justice system officials; and c) stigma of mental illness and stereotypes. The benefits of social mobilisation in addressing these barriers are manifold, as demonstrated through the Tostan model. / Mini Dissertation (MPhil)--University of Pretoria, 2017. / Centre for Human Rights / MPhil / Unrestricted

Maternal mortality in Nigeria is one of the highest in the world. The rate is higher in the rural communities than in the urban. Given the complexity of causes of maternal mortality, it appears that the community is an important resource that is frequently overlooked. The contribution of which could be explored through collaboration with professional healthcare providers, to bring about reduction in maternal mortality. This study, proposed to empower members of the community to take action to prevent maternal mortality. Action research design was utilised, comprising cycles of fact-finding, planning/action, and evaluation with the aim of working towards a change in the status quo. In collaboration with the action research group, data were generated through 29 interviews, 8 focus group discussions and observation of 7 persons. Women of childbearing age were interviewed to gain understanding of their knowledge, attitude and practice towards maternal mortality. Focus group discussions were carried out with a cross section of the community. Observations were undertaken of skilled and traditional birth attendants (TBAs) in their places of practice. Altogether, there were 86 general participants and 12 action research group members in the study. Thematic data analysis and critical reflection were undertaken with emphasis on data which promote learning and change. The study revealed childbirth fallacies as evidenced in the causes of maternal deaths being attributed to superstitious beliefs. Other findings included religious beliefs/practices, birth practices, negative attitudes, lack of money, lack of transportation and health facilities issues as contributory factors. These findings were critically reflected upon by the action research group and actions based on the findings, aimed at empowering the people to take action to prevent maternal deaths were undertaken. The actions included community education, TBA training and development of a common forum between skilled birth attendants and TBAs. Participatory evaluation was undertaken from the perspectives of the participants to identify what made sense to them from the actions. Findings included some degree of empowerment and emancipation of the people evidenced in the acquisition of new knowledge which led to the repudiation of certain superstitious beliefs. Other findings include resumed utilisation of the service of skilled birth attendants at the local health facility by the women. The findings of this study have demonstrated implications for practice, policy and research to prevent maternal mortality in Bakassi LGA, Nigeria. Conclusion drawn is that, the community is an important resource which if mobilised through the process of action research, would be empowered to take action to prevent maternal mortality. The process will also foster the collaboration between skilled birth attendants and traditional birth attendants to improve maternal health care in the rural community.

The aim of the study is to investigate how Facebook is used to facilitate and inspire collective action. This will be done through a case study of the Swedish network of volunteers and professionals #vistårinteut [We Will Not Stand It] (VSIU). Further the aim is to examine what it is that makes people convert their concerns on social change into collective action by mobilisation in the network. Because they are part of the same network, the participants are assumed to have aspects as identity, motive, and purpose in common and the perception of collective identity and interest will be part of the study. The method for data collection is internet-based using two steps; 1) web-based survey and; 2) focus groups investigated through Facebook. Furthermore a Coding Scheme will be used to analyse the results through the theoretic framework of Collective Action theory, and the four solution categories to the Collective Action problem; market category, community category, hierarchy category and contract category. Eleven solution groups are selected due to the potential of social media to influence the capacity of each solution.The most noticeable solution category in the results from VSIU is Community with strong indications of both common knowledge and common values, contributing to a steady community building and collective action online and in the streets. Facebook contributes to the common identity and community building by providing availability to information and support within the group. Another significant characteristics of Facebook as platform for collective action is the breakdown of geographical, political and social barriers.However Community solely is discovered to be insufficient to solve the collective action problem and demands for solutions from at least one other category.

The aim of this thesis is to understand how the political mobilisation of migrant domestic workers (MDWs) employed in Lebanon started and continued. It also tries to comprehend how some of them could found a politically active collective of MDWs, the Alliance of Domestic Workers in Lebanon (Alliance), by analysing what factors enabled and restrained the open political activism of MDWs from their first steps as activists until now. Drawing on semi-structured interviews with two founding members and seven international and Lebanese organisations, the MDWs´ political mobilisation is chronologically recaptured. Extending Lahusen´s definition of political mobilisation, the thesis critically reflects on Johnston´s concept for protest to evolve in repressive states. The analysis shows that the women activists are left in a lawless position and refer to the free spaces of Lebanese and international non-profit organisations, where their activism begins. These organisations help the women to build up their protest capital, enabling them to start their own group, the Alliance. Within their own group they organise themselves not only against the injustice they experience as MDWs but also emancipate themselves from their dependency on the NGOs. The findings approve that though international and Lebanese organisations have played a crucial part in successfully mobilising the women, the MDWs´ experience of lack of influence inside these free spaces, shapes the group´s actions, collective identity and course. Their political mobilisation can be seen as a long-term, organic process, in which knowledge, collective identity, collective action and experience are tightly interwoven and are the motor behind the members´ activism.

Objective: In three kvasi-experimental single-case studies regarding patients with neck-pain who after sub-grouping using Treatment Based Classification (TBC), were placed in the subgroups centralization or mobilization, describe how and why they were placed in that particular subgroup and then to evaluate the effects on function and pain of the specific treatment proposed for that subgroup.    Method: The process of sub-grouping is described. Function and pain were measured with the Neck Disability Index (NDI) and Numeric Pain Rating Scale 0-10 (NPRS) before, during and after the treatment-period and 1 month after the treatment-period had ended.    Results: The use of TBC showed positive results with increased levels of function and decreased patient-reported neck pain in all three single-cases.    Conclusion: The TBC-system may be used for improving function and pain in patients with neck pain. More studies of the validity and reliability and randomized studies of the TBC-system are needed before it could be recommended generally for physiotherapists.

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.