The diploma thesis deals with alternative design of bridge on highway D1 near Považská Bystrica. Bridge is designed as composite steel-concrete bridge with 6 spans in length 35,7m + 42m + 42m + 42m + 42m + 35,7m. Overall length of superstructure of the bridge is 241m. Construction material used in design is steel S355, concrete C35/45 and reinforcing steel bars are grade B500B. Calculation of superstructure of two variants was performed in preliminary design. First variant is twin-girder structure system and box-girder structure system is second variant. Selected twin-girder bridge was developed in more complex structural design report. Direct erection in place with temporary piers was selected as assembly method of steel structure. Slab concreting will be done by mobile formwork. The design and calculation of the bridge structure was carried out according to valid European design codes. The diploma thesis includes engineering report, structural design report of variants, structural design report of final variant, bill of quantities of assembly parts and drawing documentation.