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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"murikatacina"" "subject:"muricatacin""

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Dizajn, sinteza i antiproliferativna aktivnost prirodnih citotoksičnih laktona i analoga / Design, synthesis and antiproliferative activity ofnatural cytotoxic lactones and analogues

Srećo Zelenović Bojana 28 February 2013 (has links)
<p>Ostvarene su vi&scaron;efazne sinteze prirodnih citotoksičnih laktona (+)-murikatacina (<strong>1</strong>),<br />(&ndash;)-murikatacina (ent-<strong>1</strong>) i (+)-goniofufurona (<strong>2</strong>), kao i njihovih novih analoga (<strong>3a</strong>,&nbsp; <strong>4</strong>,<br /><strong>5</strong>,&nbsp; <strong>6</strong>,&nbsp; <strong>7</strong>,&nbsp; <strong>8</strong>,&nbsp; <strong>9</strong>,&nbsp; ent-<strong>7&nbsp;</strong>i ent-<strong>9</strong>), polazeći iz&nbsp; D-ksiloze ili iz&nbsp; D-glukoze. Ispitana je&nbsp; in vitro<br />citotoksična aktivnost sintetizovanih prirodnih proizvoda i analoga prema<br />odabranim humanim tumorskim ćelijskim linijama (K562, HL-60, Jurkat, Raji, HT-29,&nbsp;MDA-MB 231 i HeLa), kao i prema ćelijama fetalnih fibroblasta pluća (MRC-5).</p> / <p>Multiphase synthesis of natural cytotoxic lactones&nbsp; (+)-muricatacin (<strong>1</strong>),<br />(&ndash;)-muricatacin (ent-<strong>1</strong>) and (+)-goniofufurone (<strong>2</strong>), as well as synthesis of their<br />analogues (<strong>3a</strong>,&nbsp; <strong>4</strong>,&nbsp; <strong>5</strong>,&nbsp; <strong>6</strong>,&nbsp; <strong>7</strong>,&nbsp; <strong>8</strong>,&nbsp; <strong>9</strong>,&nbsp; ent-<strong>7</strong>and&nbsp; ent-<strong>9</strong>) was achived from&nbsp; D-xylose or<br />D-glucose as starting compounds. In vitro cytotoxic&nbsp; activity of synthetized natural<br />products and analogues against selected human tumour cell lines (K562, HL-60,<br />Jurkat, Raji, HT-29, MDA-MB 231 and HeLa) and against cells of natural foetal lung&nbsp;fibroblasts (MRC-5) was examined.</p>

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