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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 10 of 13 (0.044 seconds)Spelling suggestions: "subject:"mustard""
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Synthesis and reactions of therapeutic nucleophilesRafiq, Adnan January 1998 (has links)
No description available.
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| 2 |
In vivo and in vitro degradation and metabolism of p-bis (2-chlorethyl) amino-L-phenylalanine (Melphalan)Evans, Thomas Leonard January 1979 (has links)
No description available.
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| 3 |
In vitro effects of nitrogen mustard on rheumatoid and non-rheumatoid cellsRatajczak, Helen Vosskuhler, 1938- January 1970 (has links)
No description available.
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| 4 |
Synthesis and Characterization of 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-oxides and -sulfide DerivativesSimmons, Wyatt J. 10 August 2021 (has links)
No description available.
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| 5 |
Mass spectrometric analysis of chlorambucil, its degradation products and metabolite in biological samplesLarcom, Barbara Jean January 1979 (has links)
No description available.
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| 6 |
Short term effects of actinomycin D and nitrogen mustard on murine lymphocytic leukemia P388/Hazlett, Linda Dondero January 1971 (has links)
No description available.
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| 7 |
BIOACTIVATION OF CYCLOPHOSPHAMIDE FOR USE IN THE HUMAN TUMOR STEM CELL ASSAY.Bignami, Gary Steven. January 1982 (has links)
No description available.
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| 8 |
The Synthesis and Characterization of Diastereomeric Phosphorus Mustards Derived from Chiral Amino AlcoholAdjei, Bernard Louis 23 August 2019 (has links)
No description available.
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| 9 |
Kinetic studies of DNA interstrand crosslinking by nitrogen mustard and phenylalanine mustard. /Kaminsky, Margaret I. January 1990 (has links)
Thesis (M.S.)--Rochester Institute of Technology, 1990. / Includes bibliographical references, (leaves 108-110).
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| 10 |
Assessment of the Role of Poly (ADP-Ribose) Polymerase in Drug-Induced CardiomyopathyBrinkerhoff, Alexis I. 23 March 2016 (has links)
Drug-induced cardiotoxicity has resulted in a thorough evaluation of patient doses, treatments, and rehabilitation. One of the most commonly prescribed chemotherapeutic agents is cyclophosphamide. The active metabolite, acrolein, is one of the most potent inducers of cardiomyopathy. In this study, research was conducted on the H9c2 (2-1) cardiomyocyte cell line derived from the embryonic myocardium of rattus norvegicus to assess its competency for evaluation of the change in poly (ADP-ribose) polymerase (PARP) activity. The application of this model to study the effects of acrolein on PARP activation was chosen as an ideal determinant of cell damage produced by nitrogen mustards. To verify the legitimacy of this model, cardiomyocytes were exposed to acrolein in varying concentrations and time durations with a subsequent protein concentration measurement determined through the BCA Protein Assay. After the normalization of samples through volume adjustments and verification of sufficient protein, other aliquots were subjected to a PARP Assay in order to measure PARP activity. PARP was activated at exposure concentrations of 75 μM in all trials, with an average detection of 0.00569 ± 0.001 mU/200ng protein. Other concentrations showed varying degrees of PARP activation, verifying the model’s competency. PARP activation implies the potential use of this model for further research into targeted molecular therapy of PARP inhibition. Therefore, this model has the ability to be used as an assessment tool for the combined use of PARP inhibitors and chemotherapeutic agents; it can be useful for future research investigating the use and efficacy of PARP inhibitors in reducing drug-induced cardiotoxicity.
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