Descriptive and taphonomic analyses of undescribed Pleistocene Tayassuidae from Guy Wilson Cave within the East Tennessee State University and McClung Museum collections revealed a MNI of 16 Platygonus compressus and 2 Mylohyus from left femora and isolated teeth, respectively. Linkage between upper dentition and species identification is suggested by comparing Mylohyus fossilis to M. nasutus from other Pleistocene-aged sites. Long-bone NISP and age profiles show a predominance of Platygonus adults. Tayassuidae upper canines, likely Platygonus, suggest sexual dimorphism. Long bones were analyzed for carnivore damage and utilization revealing light utilization similar to that caused by modern wolves. Long bone weathering is predominantly light and suggests limited exposure prior to burial. Results indicate the cave was likely used as a carnivore den, possibly from dire wolf, for a period of time. No stratigraphical excavation data were available for either collection; therefore, additional excavations are needed to confirm these findings.