The objective of the study was to assess the effectiveness of the Feuerstein's Instrumental Enrichment training (FIE) in respondents with Parkinson's disease (PD) in comparison with another type of cognitive training. The specific aim of the study was to verify whether there were differences between the effectiveness of the FIE and the training of the individual cognitive domains for cognitive functions in respondents with PD. The study included patients with PD who underwent an examination by a neuropsychological battery before the beginning of the training in order to evaluate the level of cognitive functions. Based on the demographic characteristics and the overall score in the Mattis Dementia Rating Scale-II (DRS-II), the respondents (n = 24) were randomly divided into two research groups. The experimental group (EXP) trained using the FIE method for 60 minutes once a week during three months. The control group (CON) trained the individual cognitive domains. After the cognitive training the respondents were examined again in order to detect changes of the level of each one of the cognitive functions. The examination revealed significant differences in the first and the second phases of testing in the EXP respondents (n = 12) in the level of current anxiety (p = 0.024), memory for non-verbal...

The diploma thesis is dealing with the issues of people with psychotic illness on the labour market, recognition of problems, which they deal with in their work life, and identification of current possibilities, which are offered to people with psychotic illness on the labour market. The purpose of the diploma thesis is finding the limits and precautions, which could help them enter the labour market. It provides basic view of two psychotic illnesses, schizophrenia and affective disorder of personality. Both illnesses are discussed with regard to their symptoms, cause of origin and progression of the disease, focusing on their employability. The diploma thesis sums up the employment situation of people with psychotic illness and the attitude of society towards them. Empirical survey verifies the established hypothesis and analyzes the results of the questionnaire survey among the patients of Psychiatric hospital Bohnice. Key Words psychotic illness, mental illness, shizophrenia, affective disorder of personality, labour market, unemployment, employability at labour market, stigmatization

This thesis seeks to verify the concept of so-called resource curse at the beginning of the new millennium. The theoretical part defines the symptoms of the alleged curse, curse transmission channels and criticism of the concept. Compared to other studies dealing with the theme of the resource curse this work is not focused on just one transmission channel. The practical part verifies several hypotheses established by comparing research papers on impacts of natural resources. The validity of the Prebisch-Singer hypothesis, Dutch disease symptoms and a negative impact on political institutions (inclination toward authoritarianism, high level of corruption, high government spending, low efficiency of economic and political decision-making and low investment in education) is verified. For the analysis have been selected two African countries (Nigeria and Botswana) and two advanced countries (Canada and Norway). The last part of this thesis provides policy implications. The results confirm the Prebisch-Singer hypothesis for selected commodities in the long term and some of the symptoms of Dutch disease at the beginning of the new millennium. Hypotheses regarding the impact on the political institutions have not been confirmed, since the results varied across the countries. The high vulnerability of the countries to movements in commodity prices was found.

Diplom thesis discusses a question of influence of mineral resources on politics and economics in chosen countries of Sub-Saharan Africa. The paradox of low economic development of many resource rich countries significantly engaged in international trade is often discussed by economic experts. I decided to focus on Sub-Saharan Africa because I consider this region to be unable to fully use its potential for economic development despite being very rich in natural resources.Target of this thesis is to find out which natural resources exist in chosen countires, how the countries manage them, how successfull their economic development is, which problems they currently handle and how their current situation is related to their historic, cultural and politic background. For the purpose of my thesis I have chosen Nigeria, Democratic Republic of Congo and Botswana.

Screening of global cognitive performance is of great importance in the detection of early cognitive impairment in neurodegenerative diseases. In contrast to complex neuropsychological assessment, cognitive screening tests offer some advantages as saving time or finance and administration of screening tests makes lower demands on clinicians. Validation of cognitive screening tests for specific diagnostic groups of patients is necessary as well as Czech normative studies that enable an objective evaluation of the cognitive performance of Czech patients. In the theoretical part, we presented the syndrome of mild cognitive impairment as a pre-dementia state in neurodegenerative diseases. We focused on the assessment of mild cognitive impairment and using five different cognitive screening tests (Mini-Mental State Examination, Montreal Cognitive Assessment, Dementia Rating Scale 2. edition, Frontal Assessment Battery, Clock Drawing Test) in the detection of cognitive impairment. Then we focused on Parkinson's disease (PD), especially on the evolution of different stages of cognitive deficit in PD and their detection by cognitive assessments. The empirical research included studies analyzing the potential of the five cognitive screening tests to detect mild cognitive impairment. We provided results...

This diploma thesis focuses on the automated diagnosis of hypokinetic dysarthria in the multilingual speech corpus, which is a motor speech disorder that occurs in patients with neurodegenerative diseases such as Parkinson’s disease. The automatic speech recognition approach to diagnosis is based on the acoustic analysis of speech and subsequent use of mathematical models. The popularity of this method is on the rise due to its objectivity and the possibility of working simultaneously on different languages. The aim of this work is to find out which acoustic parameters have high discriminative power and are universal for multiple languages. To achieve this, a statistical analysis of parameterized speech tasks and subsequent modelling by machine learning methods was used. The analyses were performed for Czech, American English, Hungarian and all languages together. It was found that only some parameters enable the diagnosis of the hypokinetic disorder and are, at the same time, universal for multiple languages. The relF2SD parameter shows the best results, followed by the NST parameter. When classifying speakers of all the languages together, the model achieves accuracy of 59 % and sensitivity of 72 %.

The task of this thesis is to familiarize readers with the basics of the problem of ionizing radiation from its types and resources, through mechanisms of action and its effects on the human organism, to the possibility of calculating various characteristics. Close attention is paid to the use of ionizing radiation in medical approaches. There is in detail described process of radiotherapy planning and a basic properties of planning systems. Part of the thesis is also program RT-Plan processed in Matlab. The program simulates the planning system for external ionizing radiation therapy used in treatment. There is supplemented a detailed help and series of tests for the plan. It is suitable for possible use in teaching.

This master´s thesis deals with the calculation of parameters that would be able to differentiate healthy speech and speech impaired by hypokinetic dysarthria. There was staged hypokinetic dysarthria, which is a motoric disorder of speech and vocal tract. Were studied speech signal processing methods. Further parameters were studied, which could well differentiate healthy and diseased speech. Subsequently, these parameters were programmed in Python programming language. The next step was to create a web application in Django framework, which is used for the analysis of the dyzartic speech.

Therapies of neurodegenerative diseases are often very difficult and their success depend on an early diagnose. From that reason we have been developing new diagnostic method for multiple sclerosis and Alzheimer disease by drop coating deposition Raman (DCDR) spectroscopy of cerebrospinal fluid (CSF) in this work. We found out conditions of measurements, where spectra were reproducible and accepted for standard diagnostic practices. We discovered that CSF has fast degradation at a room temperature, which was detectable in spectra after 5 hours, and degradation due to refreezing. DCDR spectra of CSF from individual patients were analyzed by factor and cluster analysis. Multiple sclerosis was manifested by lower intensity of a Raman band at 1080 cm−1 , which is probably connected with more general pathologic state. Spectral changes caused by Alzeheimer disease were more complex and beside changes mentioned above also changes connected with composition and conformation of proteins were identified in regions 1200-1800 cm−1 and 2870-2950 cm−1 . Additionally, we succeeded in distinguishing of young healthy patients from older patients in DCDR spectra. In this work were checked up, that DCDR is good diagnostic method for clinical practices for determining neurodegenerative diseases through the complex...

In the theoretical part of my thesis I define the illness, venous thromboembolic disease. The theoretical principles are used to determine the risks of the disease onset in women, primarily focused on the risk related to the hormonal contraception usage and the hormone replacement therapy. Attention is paid to the diagnosis, treatment and prevention of the DVT as well. In the following chapters the readers will be apprised with the treatment procedures, primarily from the nursing care perspective. The theoretical part of the thesis will be concluded with the casuistry of patient who suffers the thromboembolic disease and who was in my personal nursing care. The empirical part of my thesis is aimed on the qualitative and related quantitative research, which will be carry out by the help of the questionnaire. The questionnaire is based on the outcoume of the data analysis (casuistry) gained at the Clinic of Cardiology, FN Motol. The questionnaire is distributed and determined for wide group of women from non-medical environment (layman). The results of my research are giving the respons on the thesis's goals and hypotheses. The maion goal of my thesis is to define the women awareness of thromboembolic disease risks, in connection with the hormonal contraception usage and the hormone replacement...