Berlin, Freie Univ., Diss., 2001. / Dateiformat: zip, Dateien im PDF-Format. Computerdatei im Fernzugriff.

Berlin, Freie Univ., Diss., 2001. / Dateiformat: zip, Dateien im PDF-Format. Computerdatei im Fernzugriff.

Berlin, Freie Universiẗat, Diss., 2001. / Dateiformat: zip, Dateien im PDF-Format.

Thesis (Ph.D.)--McMaster University, 2005. / Advisor: Chris M. Wood Includes bibliographical references. Also available online.

Thesis (M.S.)--University of Wisconsin--Madison, 1966. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (PhD)-Open University. BLDSC no.DX181454.

The ability of simple oligopeptide complexes of nickel (II) to react with various dioxygen intermediates was investigated. Under physiological conditions, nickel (II)-histidine-containing oligopeptides were found to dismutate superoxide anions and disproportionate hydrogen peroxide. In the latter process, chemiluminescence was generated and a strongly oxidizing intermediate was detected capable of oxidizing uric acid, hydroxylating p-nitrophenol, and damaging 2-deoxy-D-ribose. The generation of this reactive intermediate likely occurs without the involvement of free hydroxyl radicals derived from Haber-Weiss or Fenton-type reactions. In addition, the Ni(II) complex of glycylglycyl-L-histidine (GGH) was found to react with mollecular oxygen resulting in the oxidation of the ligand. An attempt was made to relate these reactions to the involvement: of the nickel(III)/(II) redox couple which was shown to exist under physiological conditions. Similar reactivity was observed for non-histidine-containing oligopeptides but higher pH values were required. The oligopeptides used not only represent biologically relevant ligands but: the histidine containing oligopeptides mimics the specific copper(II)/nickel(II) binding and transport site of human serum albumin. The observations made in this study suggest some novel mechanism for the deleterious effects associated with excessive lifelong exposure to nickel compounds, especially in relation to cancer of the respiratory tract. / Thesis / Master of Science (MS)

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 162-169).

The damage clusters produced by low dose, 80 keV Ni⁺ and W⁺ heavy-ion bombardment of pure nickel; of two nichrome alloys (with 8% and 17%Cr); and of a ternary alloy and 321 stainless steel which have the same base composition (Fe/Ni10%/Cr17%) have been studied by means of transmission electron microscopy. In all cases where the defects could be identified with confidence they were found to be vacancy in nature. Most of the defects were identified as Frank loops, some of which had partially dissociated. The number of loops that were identified as dissociated and the average degree of dissociation were dependent on the stacking fault energy γ, being greater in the low-γ ternary alloy and the stainless steel than in the high-γ nickel and nichrome alloys. In the high-y materials a small proportion (< 5%) of perfect loops was also observed. Defect yield values were between a factor of 2 and 5 higher for W⁺ ion bombardment than for the corresponding Ni⁺ ion irradiations, but the effect on the mean defect size and cascade efficiency was much less pronounced. In the case of the Ni⁺ ion bombardment, the defect yields in the two nichrome alloys were lower than in pure Ni. No such effect was observed for the W⁺ ion irradiations, when defect yield and cascade efficiency values very similar to those of pure nickel were obtained. The defect yield in the W⁺ ion irradiated ternary alloy was considerbly smaller than in the nichrome alloys and there was a further major decrease in the stainless steel. These reductions in defect yields were not accompanied by a change in the mean defect size nor in the distribution of the defect sizes which were very similar in all the materials for irradiation by a given ion species. The defect yield in W⁺ ion irradiated Ni remained constant with increasing irradiation temperature up to ~450°C and then decreased sharply at higher irradiation temperatures. The defect yield in W⁺ ion irradiated Ni/Cr17% remained constant up to at least 500°C. Possible physical explanations for these results are discussed.

Mémoire (M.Sc.T.)--Université du Québec à Chicoutimi, 1999? / Document électronique également accessible en format PDF. CaQCU