Topic of the Magister thesis is study of human knowledge about the real world. Thesis focuses on the establishment of Epistemology, a philosophical discipline that focuses on theory of knowledge, introduces its history and its relation to other philosophical disciplines, mainly onthology. Thesis thoroughly studies all epistemological conceptions, both from the epistemological and ontological points of view, including conception of subject-object relationship. Thesis studies different sources of knowledge, i.e. empirical, rational, irational, and also analytical philosophy and critical rationalism of the 20th century. Thesis includes a list of the most influencial philosophers and their concepts of human knowledge - Plato, Aristotle, Descartes, Locke, Berkeley, Hume and Kant. Thesis studies the relationship of epistemology and axiology, the philosophical study of value. Thesis studies concepts of truth of knowledge. Thesis sudies evolutionary epistemology, its theoretical starting points, principles of natural and cultural evolution, phylogenetics and epigenetics and conceptual knowledge.