Introduction: Experiences of negative parenting and childhood abuse can have adverse consequences for the child‟s development particularly in relation to the ability to regulate emotions effectively. There has been extensive research in this area and attachment theory is pivotal. Problems in regulating emotions can involve not being able to recognise, label or manage internal and external states of mind and behaviour. Therefore research has shown that problems in emotion regulation skills due to negative parental and/or abusive experiences can result in long-term psychosocial problems such as depression. Research has suggested that adults with adverse childhood experiences exhibit risky behaviours as a means of managing their emotions such as self-harming, dangerous sexual encounters and substance misuse. Although research has shown that there is an association between these factors no real understanding of the pathways and the potential mediating roles these factors play has been investigated with people presenting with suicidal behaviour, which could be argued as the ultimate form of managing emotions and therefore the internal and external self. Therefore this study aims to answer the following question: Does childhood abuse and dysfunctional emotion regulation mediate the relationship between parental bonding and suicidal behaviour. Method: This study involved sixty participants from a suicidal behaviour sample presenting at an Accident and Emergency department aged between 18 - 65. Measures assessing childhood abuse, emotion regulation, parental bonding, suicidal intent, risk of repeating suicidal behaviour, depression and anxiety were completed. Results: Childhood emotional abuse was found to significantly mediate the relationship between low parental care and risk of repeating suicidal behaviour. A lack of external functional emotion regulation strategies was also found to mediate the relationship between parental care and risk of repeating suicidal behaviour. Finally, a lack of internal functional emotion regulation strategies was found to mediate the relationship between childhood physical abuse and risk of repeating suicidal behaviour. Conclusion: Preliminary findings of this study suggest that childhood emotional abuse and dysfunctional emotion regulation play a crucial role in further understanding those who engage in and are at risk of repeating suicidal behaviour. Therefore, emotions and emotion regulation within a developmental framework are important when considering long-term adult psychosocial functioning.

Increased power densities in VLSI chips have led to a need to develop cooling methods that can cope with the increased heat produced by such chips. Currently one of the more attractive methods to meet this goal is through the use of two phase flow of a fluid as changing phase of the material allows high heat transfer rates for a low temperature change. To bring this technology to commercialisation a greater understanding of the underlying physics involved at the microscale is required as there is much debate within literature as to what occurs during two phase flow heat transfer at these scales. The work conducted as part of this thesis is a step towards improving the understanding of the mechanisms involved with this process. This thesis describes the fabrication of a novel microchannel structure, which can be used to experimentally characterise two phase heat transfer as it occurs. The final process reported for these microchannels structures provides the basis of a technology for the fabrication of microchannels with increased sensor densities. Two types of microchannel devices have been fabricated for this project. The first device of these was an array of parallel microchannels formed by the reactive ion etching (RIE) of silicon, which was then bonded with Pyrex glass. These microchannels were simple in that sensors were not integrated for local measurement. However the production of these devices incorporated fabrication techniques such as anodic bonding and inductively coupled plasma RIE that were essential to the fabrication of more complex devices. The second device built was a single microchannel that contained an integrated heater and several temperature sensors. The use of wafer bonding enabled the device to take full advantage of both bulk and surface micromachining technology as the placement of the temperature sensors on the channel floor would not be possible with conventional bulk micromachining. The initial microchannel structures demonstrated that wafer bonding could be used to fabricate novel devices, but they highlighted the difficulty of achieving strong anodic bonds due to the presence of dielectric films throughout the fusion bonded wafer stack used in the channel fabrication. To improve the performance of the device the process was optimised through the use of insitu, non-destructive test structures. These structures enabled the uniformity and strength of the bonds to be optimised through visualisation over the whole wafer surface. The integrated sensors enabled temperature measurements to be taken along the channel with a sensitivity 3.60 ΩK-1 while the integrated heater has delivered a controllable and uniform heat flux of 264 kWm-2.

Mothers who have an infant with severe congenital heart disease (CHD) face an uncertain and emotionally challenging postpartum period as their baby is hospitalised and undergoes life-saving cardiac surgical treatment. There are many potential risk factors to mother-infant bonding, that is, the emotional tie a mother develops with her baby, in the context of infant illness. Having an infant with a diagnosis of severe CHD could be seen as a threat to the mother's experience of bonding. However, there is limited understanding about the maternal perception of bonding with an infant with severe CHD. This study aimed to explore mothers' bonding with their infant with severe CHD throughout antenatal, perinatal and postnatal periods and how they coped with any challenges to this bond. Interviews were conducted with eight mothers of infants aged between eight and fifteen months with severe CHD, who were recruited from a children's hospital and who were diagnosed either antenatally or postnatally. Interpretative Phenomenological Analysis was used to identify themes across the mothers' accounts. Four superordinant themes were identified: ‘An Emotional Start to Motherhood and the Mother-Infant Bond', ‘Losing Control in the Context of CHD', ‘Keeping Connected to the Baby' and ‘Moving on Together'. The findings identify mother-infant bonding as a process that can withstand challenges such as maternal-infant separation, potential loss of the infant and maternal feelings of disconnection from the baby. Practical strategies were used by mothers to maintain their bond with their infant following diagnosis and during hospitalisation. These included being close to their infant and taking over caregiving duties from the nurses. Mothers described strength and resilience from the experience and a process of increasingly feeling closer to their infant. Several potential research implications and clinical recommendations for healthcare professionals are suggested.

Women face a number of physical, emotional and psychological challenges following an HIV positive diagnosis during pregnancy. Psychological challenges, such as maternal anxiety and low mood, have been associated with disruptions to mother-infant bonding in the general population. Despite significant numbers of women receiving an antenatal HIV diagnosis in the UK each year, there remains a limited understanding about the experiences of this group in bonding with their babies. This Grounded Theory study aimed to explore the experience of mothers in bonding with their baby following an HIV diagnosis during pregnancy. The study explored the perceived challenges to mother-infant bonding, and the factors mothers felt helped them to manage this process following diagnosis. Ten mothers diagnosed antenatally at a London sexual health service were interviewed about their experiences. Data analysis led to a theoretical model of mother-infant bonding following a maternal HIV positive maternal diagnosis. The model comprised four theoretical codes: facing barriers to bonding; feeling disconnected from the baby; developing a special bond; and strengthening and moving on. These codes were comprised of challenges to mother-infant bonding, as well as factors relating to maternal strength and resilience. The model used a chronological structure, with processes plotted from the point of antenatal diagnosis through to following the infant HIV testing process after birth. Challenges with bonding were experienced primarily during the early stages after birth, with maternal resilience and positivity about the future developing towards the end of infant testing. Circular relationships, in which positive and negative processes fed into and influenced each other, were highlighted throughout. The findings highlight important areas for development in clinical practice, including more targeted psychological support for women following an antenatal diagnosis, and the provision of timely information regarding mother-to-child transmission. Clinical implications from this study are discussed alongside suggestions for future research.

Abstract According to Bowlby, infants have a universal need to seek close proximity with their caregiver when under distress or threatened. This study seeks to look at attachment in a population that is undergoing extreme distress as they suffer from opioid withdrawal within the first few weeks of life. It aims to explore the role touch (kangaroo care) can have in creating the secure base that attachment theorists describe as the basis for all future attachments, and in reducing the length of Neonatal Abstinence Syndrome. It is hypothesized that infants born with drug dependencies who receive increased touch and holding throughout their withdrawal will have a shorter duration of Neonatal Abstinence Syndrome and will be more securely attached at 18 months than those who do not receive increased touch. It is also hypothesized that infants whose caregivers reported high scores of bonding with their infants in the first year of life will be more securely attached than those with lower scores of bonding. Infants who were sent home with their birth parents after discharge are hypothesized to be more securely attached at 18 months with their caregiver than infants who were sent home to a foster family. The results of this study will contribute to attachment literature in a population where research is lacking, and will add to the knowledge on Neonatal Abstinence Syndrome treatment.

Proximal and Distal Indirect Influences on Adolescent Sexual Activity and Post Risky Sexual Behaviors INTRODUCTION: Prior literature has revealed a correlation between adolescent sexual debut and parenting behaviors. However, most existing studies has only focused on parental monitoring and control. This limitation, in addition to small, cross-sectional studies, has resulted in inconsistent and limited findings. These gaps are addressed in this present paper by investigating how family connectedness contributes to the age of sexual debut. It is hypothesized that adolescents who are 13 years of age and have a lack of family connectedness engage in high-risk behaviors sooner than their 13-year-old peers with greater family connectedness. METHODS: Data were drawn from the 1997 National Longitudinal Survey of Youth. This paper focused on adolescents born in the year 1983 who had no sexual debut at baseline. Those selected were initially interviewed for baseline family connectedness and prospectively followed up to adulthood. Family connectedness was measured using five aspects: shared activities, parent-adolescent communication, parent admiration, parental support and the presence of family dinners. SAS 9.4 was used to perform survival analyses to examine the rate of teenage sexual debut by family connectedness. RESULTS: Findings suggest that family connectedness, specifically weekly family dinners and parent-child communication were significant familial factors that delayed adolescent sexual behavior. The hazards ratio of having an adolescent sexual debut at any time for an individual who had family activity at least once a week was 0.91 (95CI: 0.74, 1.14), having weekly family dinner (HR 0.70; 95CI: 0.53, 0.93), communication with parents (HR 0.78; 95CI: 0.68, 0.91), perceived parental support (HR 1.04; 95CI:0.91, 1.02), think highly of parents (HR 1.08; 95CI 0.93, 1.25). CONCLUSION: This study attempted to observe other factors outside of the parental monitor and control that could contribute to adolescent sexual activity. However, family connectedness was found to be a protective factor only among family weekly dinner and parent-child communitcation. Public health policy and interventions aimed at family connectedness alone will unlikely influence adolescent sexual behaviors. Therefore, other factors along with family connectedness should be further assessed to discover its true correlation on sexual debut.

With three different proposals for the bonding in metal carbonyls, it was decided to look into the situation more thoroughly in order to see what other evidence was available to support or refute any of these ideas. It became obvious that a definite contradiction existed between the kinetic evidence of various metal carbonyls, and the concept of MC bond strengths as predicted by Cotton's theory.

Inverse systems, inverse limit spaces, and bonding maps are defined. An investigation of the properties that an inverse limit space inherits, depending on the conditions placed on the factor spaces and bonding maps is made. Conditions necessary to ensure that the inverse limit space is compact, connected, locally connected, and semi-locally connected are examined. A mapping from one inverse system to another is defined and the nature of the function between the respective inverse limits, induced by this mapping, is investigated. Certain restrictions guarantee that the induced function is continuous, onto, monotone, periodic, or open. It is also shown that any compact metric space is the continuous image of the cantor set. Finally, any compact Hausdorff space is characterized as the inverse limit of an inverse system of polyhedra.

The beginning of life is an intense experience for both mother and baby and sets the foundation for future interactions. Researchers have theorized that maternal infant bonding begins prenatally and continues on through the postnatal period. Mṻller (1996) examined that process to determine if prenatal bonding was related to postnatal bonding and discovered that there was only a modest correlation between the two. This led to speculation as to what variables, besides prenatal bonding, could influence postnatal bonding. Klaus & Kennell (1976) noted the detrimental effects of a lack of bonding in terms of abuse and attachment disorders and emphasized the urgency of understanding the process. Thus, an examination of factors that influence the initial attachment after birth is important in order to facilitate the experience for optimal outcomes. The purpose of this study was threefold: 1. Examine the relationship between a woman’s perceived birth experience and maternal infant bonding; 2. Examine the relationship between spirituality and maternal infant bonding; 3. Examine the relationship between perceived birth experience and maternal infant bonding. Women were recruited for an internet survey through various childbirth websites, nurses’ associations, and perinatal listserv communications. A total of 402 women responded to the survey, which consisted of 67 items in three instruments: Perception of Birth Scale; Spirituality; and Maternal Attachment Inventory. Of these respondents approximately 300 finished the survey completely and were used in the analyses. Slightly more than 190 left extensive comments regarding their experiences. Predictive Analytical Software (PASW 18) was used to analyze data and correlations were run on the measurements of the three instruments as well as a regression analysis. Perceived birth experience had the strongest correlation to maternal infant bonding and was found to have a stronger influence on bonding as well.

Objective: This study aimed to assess the impact of in vitro erosion provoked by different cola-based drinks (Coke types), associated or not with toothbrushing, to bonding to enamel. Material and methods: Forty-six bovine enamel specimens were prepared and randomly assigned into seven groups (N=8): C- Control (neither eroded nor abraded), ERO-RC: 3x/1-minute immersion in Regular Coke (RC), ERO-LC: 3x/1-minute immersion in Light Coke (LC), ERO-ZC: 3x/1-minute immersion in Zero Coke (ZC) and three other eroded groups, subsequently abraded for 1-minute toothbrushing (EROAB-RC, EROAB-LC and EROAB-ZC, respectively). After challenges, they were stored overnight in artificial saliva for a total of 24 hours and restored with Adper Single Bond 2/Filtek Z350. Buildup coronal surfaces were cut in 1 mm2-specimens and subjected to a microtensile test. Data were statistically analyzed by two-way ANOVA/Bonferroni tests (a=0.05). Failure modes were assessed by optical microscopy (X40). The Interface of the restorations were observed using Confocal Laser Scanning Microscopy (CLSM). Results: All tested cola-based drinks significantly reduced the bond strength, which was also observed in the analyses of interfaces. Toothbrushing did not have any impact on the bond strength. CLSM showed that except for Zero Coke, all eroded specimens resulted in irregular hybrid layer formation. Conclusions: All cola-based drinks reduced the bond strength. Different patterns of hybrid layers were obtained revealing their impact, except for ZC. / This study was supported in part by grants given by the São Paulo Research Foundation (FAPESP), Process no. 2009/14986-0, and the National Council for Scientific and Technological Development (CNPq), Process no. 480038/2007-4. In Addition, this study was performed by V.D.M. and A.C.H. as fulfillment of their graduation research, which was supported by FAPESP (Processes no. 2009/01376-9 and 2009/01377-5, respectively). The authors are also grateful to Oral B and SDI, which donated the materials used in the study. / Revisión por pares