The present investigation was carried out in a patient with the adrenogenital syndrome who was found to have an adrenal tumor. The urinary corticosteroids and 17-ketosteroids were studied during three different periods: before any treatment, on cortisone administration, and after surgical removal of the tumor.

Progress in surgical therapy is based upon the firm understanding of the anatomical, physiological and pathological processes involved in any specific disease entity. Each contribution must necessarily be only the addition of a brick, or at best a keystone, to the vast masonry work of scientific knowledge. [...]

These studies report attempts to induce ketosis in diabetic patients in order to obtain more information about fat and ketone metabolism in different clinical types of diabetes mellitus. All patients with diabetes mellitus have impaired ability to accelerate the metabolism of carbohydrate leading to varying degrees of hyperglycemia and glycosuria. As well as this abnormality in carbohydrate metabolism, there are abnormalities in fat and ketone metabolism which are different in the various clinical types of patients with diabetes mellitus. These studies were designed to quantitate some of these differences.

The studies on carcinogenesis in hamsters represent actually a relatively new field of development. Gye and Foulds were the first to induce experimentally sarcomas in hamsters in 1940. This was followed by sporadic work of Ashbell (1945) and Shrader (1946), who reported on spontaneous tumors in hamsters, and that of Crabb, who induced sarcomas by injection of 9, 10 dimethyl 1, 2 benzanthracene in 1946. The extensive studies of carcinogenesis were initiated by the work of Kirkman and Bacon (1952), who reported the effects of various hormonal factors in male and gonadectomized female hamsters.

Various electrical methods for the diagnosis and study of human physiology and pathology are now in general use. The most important of these are the electrocardiogram, electroencephalogram and electromyogram. All are a measure of the electrical activity within the tissues of the organ under study. Pathological changes within the tissue cells are reflected by a change in electrical recordings from the normal. Clinical progress has been considerable with these electrical devices.

It is well known that since the advent of insulin and later the antibiotics, the acute complications of diabetes mellitis have become a remedial rarity and that the late vascular complications have assumed far greater prominance with regards both morbidity and mortality. Of these pathological changes only those that affect the retinal and glomerular capillaries can be considered unique for the diabetic subject. [...]

Since 1932, when Crohn, Ginzburg and Oppenheimer conceived the concept of regional enteritis (40), the disease has been subjected to the scrutiny of accumulating clinical experience and experimental observations. Admittedly, considerable information concerning its incidence, distribution, course, therapy, and diagnosis, has been added to the original description. Yet, despite diligent efforts, speculations, and experimental works throughout these years, there is little definite knowledge regarding the etiology and pathogenesis, and the disease has not been reproduced in experimental animals.

For many years Legg-Calvé-Perthes’ disease has been, and still is, an outstanding problem in the field of orthopaedic surgery because of the discomfort, mental anguish and prolonged convalescence it imposes. It is a problem also because of pain, deformity and disability which it frequently produces during early or middle adult life. Although considerable has been written on Legg-Calvé-Perthes’ disease, very little has been done to investigate the possible etiological factors which may initiate it.

In the bibliography of this thesis, the authors are listed in alphabetical order. In the text, the references are given by the name of the author or authors and the year of publication. When the same author or authors published two or more papers in the same year, to avoid confusion, the papers are indicated in their order of publication by adding to the year small letters of the alphabet. Thus Moore, Sandberg and Watne published two papers in 1960. The first is listed as Moore, Sandberg and Watne (1960 a), and the second as Moore, Sandberg and Watne (1960 b).

Rougnon, a French physician published the first case in 1768, (164), and Heberden, an English physician, in the same year gave the name angina pertoris to the clinical state of coronary ischaemia.(87). Since then many authors have concerned themselves with the nature of the disease while the treatment concerned Duchenne (55) and the rest as early as 1855. At the present time the terms atherosclerosis and occlusive vascular disease of the coronary arteries are synonymously used in the consideration of ischaemic heart disease.