This thesis considers the problem of hypothesis testing for umbrella alternatives when there are two groups, or strata, of observations. The proposed methods extend a previously established general framework of hypothesis testing based on rankings to stratified datasets by first aligning the strata. The tests based on the Spearman and Kendall distances between ranking vectors lead to the traditional aligned-rank tests and new methods which account for “misalignment” under the alternative hypothesis. Asymptotic null distributions and simulation studies are given for the Spearman distance. Diagnostic tools for the misalignment issue are illustrated alongside the proposed tests on a dataset of IQ scores of coma patients. Extensions to three or more strata and ”adaptive” tests are provided as future research directions.

Osteoarthritis is the most common form of arthritis. Genetic models have been developed to determine if and how a targeted gene may influence cartilage degenerative changes. The itga1-null mouse model has an inhibited integrin α1B1 through a ubiquitous integrin α1 subunit knockout, which leads to fibrosis in articular cartilage through excessive signalling from transforming growth factor beta (TGFB). Depleting this TGFB signalling is proposed to have a protective effect on cartilage. This project is part of a foregoing study where a cartilage-specific knockout of TGFB receptor type II (TBRII) was used to deplete TGFB signalling in articular cartilage of the itga1-null mice to reduce the severity of cartilage degradation. This project continues the analysis of the genetic model into bone architecture at the knee. Mouse hindlimbs were scanned at a 13μm resolution using micro-computed tomography and segmented into 3D datasets containing calcified tissues and bone of the knee and surroundings. Quantification methods for trabecular bone parameters (bone volume fraction, trabecular separation, and trabecular thickness) and ectopic calcification of soft tissues were developed. Loss of trabecular bone around the involved joint is a hallmark of post-traumatic osteoarthritis. However, the results from this study showed no significant changes in trabecular bone of itga1-null mouse knees despite observing severe osteoarthritic changes in the adjacent cartilage. There were no significant effects in peri-articular trabecular bone when the TBRII knockout in cartilage was activated, but there were significant increases in ectopic calcifications of the menisci and collateral ligaments. These ectopic calcifications were also seen in tamoxifen control mice, suggesting that tamoxifen, along with TBRII depletion in cartilage, had a role in increased abnormal calcifications. Although integrin α1B1 inhibition appears to have an important role in cartilage degeneration, it does not appear to influence the bony changes that normally accompany post-traumatic arthritis. / Thesis / Master of Applied Science (MASc) / Osteoarthritis is a common joint disorder, associated mainly with cartilage degradation. Some genes have been identified that cause or prevent osteoarthritis. A previous study used two of these genes in a genetic mouse model to explore how osteoarthritis may develop. Removing the integrin α1 subunit from mice caused osteoarthritic changes in the cartilage of the mouse knee. When the transforming growth factor beta gene was removed from the cartilage, these changes were less severe. This project continued the study by exploring changes in bone around the mouse knee. We quantified bone changes around the mouse knee using high-resolution micro-computed tomography scans. Contrary to common findings in post-traumatic osteoarthritis, we found that there were no significant changes in the bone around the knees even where severe cartilage changes had been identified. However, there were significant increases in calcifications of soft tissues including the meniscus and ligaments around the knee.

Drone-mounted ground penetrating radar (GPR) has the capability to investigate terrain that is inaccessible or hazardous to humans. A linear frequency-modulated (LFM) radar with the potential for GPR applications is described based on the LimeSDR Mini software defined radio (SDR). Challenges of the LimeSDR Mini radar include the SDR's lack of support for transmitter-receiver synchronization and high bleedthrough leakage. These issues are overcome through corrective software processing techniques including deconvolution of the SDR's system impulse response and digital feed-through nulling. Feed-through nulling is effective at reducing bleedthrough leakage, achieving a 26 dB reduction in power. Although high noise can confound the identification of targets with small radar cross sections in dynamic environments, the LimeSDR Mini radar is demonstrated to display a moving target across multiple ranges. This research demonstrates the increasing accessibility of SDR radar for drone applications, as the LimeSDR Mini is lightweight and low-cost compared to high-end SDRs typically used in SDR radar.

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The present study examines certain syntactic properties of the Brazilian variety of Portuguese (BP): 1) BP is a pro-drop language with instances of both null subjects and covert objects, and 2) BP exhibits several possible word orders. To determine the frequency of pro-drop and word-order variations, the CDP (The Portuguese Corpus) was used to provide samples of transitive, main clauses, which were then categorized based on whether or not they had null subjects and covert objects. The clauses were also categorized according to word order. In addition to providing samples, the corpus allowed for the comparison of four different registers of BP: academic, newspaper, fiction, and oral. The results of the present study demonstrated that null subjects are much more common than covert objects (29.4% and 2.3% respectively) and that register did significantly affect the frequency of pro-drop, with oral having the highest rate of pro-drop and newspaper the lowest. For word order, SVO was most common at 95.1% with the occurrences of other variations being too rare to reliably determine statistical significance. Different from pro-drop, register did not affect the frequency of different word orders. Word-order variations were not random, however, but were determined by topic and focus with old information (topic) generally occurring preverbally, and new information (focus) generally occurring in the most embedded position. The fact that this study effectively examined these syntactic features is significant, as most of the Portuguese syntactic research previous to the present study was specific to European Portuguese. The present study demonstrated a new methodology being successfully applied to a different dialect, but more than that, it demonstrated that a more empirical, data-driven approach to syntactic research is both possible and valuable, justifying the creation and use of large corpora for this type of research.

Yes / A quasi-orthogonal space time block coding (QO-STBC) scheme that exploits Hadamard matrix properties is studied and evaluated. At first, an analytical solution is derived as an extension of some earlier proposed QO-STBC scheme based on Hadamard matrices, called diagonalized Hadamard space-time block coding (DHSBTC). It explores the ability of Hadamard matrices that can translate into amplitude gains for a multi-antenna system, such as the QO-STBC system, to eliminate some off-diagonal (interference) terms that limit the system performance towards full diversity. This property is used in diagonalizing the decoding matrix of the QOSTBC system without such interfering elements. Results obtained quite agree with the analytical solution and also reflect the full diversity advantage of the proposed QO-STBC system design scheme. Secondly, the study is extended over an interference-free QO-STBC multi-antenna scheme, which does not include the interfering terms in the decoding matrix. Then, following the Hadamard matrix property advantages, the gain obtained (for example, in 4x1 QO-STBC scheme) in this study showed 4-times louder amplitude (gain) than the interference-free QOSTBC and much louder than earlier DHSTBC for which the new approach is compared with.

Asynchronous design is a possible alternative design methodology that has the ability to alleviate issues associated with clock skew, power dissipation, and process and environmental variability among transistors, issues encountered in typical synchronous design methodologies. This investigation studies the implementation of two asynchronous models of the Texas Instruments MSP430 processor family using a logic system known as Null Convention Logic (NCL). The study also investigates two design styles of NCL: the data-driven and control-driven design styles. This example and others show that although there are tradeoffs in chip area and performance, the control-driven design style is a viable methodology that can lead to designs that are low in energy usage. The openMSP430 processor project is the baseline for the investigation as it is a mature open-source project. Silicon-proven multiple times and fully synthesizable, it parallels the original Texas Instruments family nearly cycle for cycle. UNCLE (Unified NCL Environment) is a toolset used to create comparable implementations of the openMSP430 architecture that are data-driven and control-driven in nature. This investigation shows that the control-driven implementation has a slightly larger chip area due to the complexity of the control path and its effects on the data path. While the control path has a lower area than the data-driven model due to area optimization, the data path of the control-driven version is larger than that of the data-driven model. Because of these issues of complexity in both the control and data paths, the performance of the model suffers as well, degrading from the already poor performance of the traditional data-driven NCL model. Along with the increase in chip area and the decrease in performance, the control-driven model sees a 50.2% average decrease in energy usage as compared to the data-driven model. As with most design choices in engineering, there are tradeoffs when using either design style of NCL. This investigation serves to allow designers to make a well-informed decision when deciding between the two.

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