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Molecular design of biomaterial systems for the oral delivery of therapeutic proteinsCarr, Daniel Aaron, January 1900 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 2008. / Vita. Includes bibliographical references.
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Molecular design of biomaterial systems for the oral delivery of therapeutic proteinsCarr, Daniel Aaron, 1983- 27 September 2012 (has links)
Not available / text
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Lipoamino acid- and carbohydrate- based penetration enhancers for use in oral drug delivery /Ross, Benjamin Paul. January 2004 (has links) (PDF)
Thesis (Ph.D.) - University of Queensland, 2004. / Includes bibliography.
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A dynamic distributed-parameter modeling approach for performance monitoring of oral drug delivery systemsEyries, Pascal. January 2003 (has links)
Thesis (M.S.)--Worcester Polytechnic Institute. / Keywords: mass balance approach; bioavailability; drug delivery; dynamic modeling; partial differential equations; sensitivity analysis; dynamic simulations. Includes bibliographical references (p. 62-67).
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A systematic review of factors improving medication safety of oral medication via enteral feeding tubes in institutionsKam, Kin-wai, 甘健威 January 2014 (has links)
Objective: Medication safety is always having great concern in healthcare. Giving oral medication through enteral feeding tubes is not uncommon and is a well-known area that prone to error happening. These errors may lead to inadequate treatment or adverse drug reaction resulting in unnecessary health care cost and wastage of public health resources. This systematic review aims to identify contributing factors on medication errors associated with administration of oral medication via enteral feeding tubes. With better understanding of the factors, improvement measures applicable to Hong Kong situations will be suggested.
Methods: Pubmed, Medline and Embase databases were searched up to February 2014 by using relevant keywords. Prospective studies with researcher analyzing the drug administration process to observe the occurrence of errors and evaluate the contributing factors and case reports on medical error with review of the place of errors and their potential root causes were considered to be potential relevant literature. Studies meeting the inclusion criteria were included and evaluated in this review. Studies were excluded based on the exclusion criteria.
Results and Discussion: An initial search of medical literature by searching engines identified 682 references. After appraisal for inclusion, 11 of them were included in this systematic review. For the findings, lack of knowledge, lack of the presence or the awareness of protocol, environmental factors, inter-disciplinary communication among healthcare professionals and the ability of inadvertent connection of both IV catheter and enteral feeding system had been identified to be key contributing factors to drug administration error. Taken account with the findings, measures to improve the existing local practice through educational reinforcement, establishing guideline and inter-disciplinary communication were suggested.
Conclusion: With consideration of the local situation in Hong Kong and the findings identified in this review, suggestions of improvement measures on different aspects have been made in this review. Involvement of government policy, institutional management and the collaboration of multi-disciplinary healthcare professional are essential for the success of these improvement measures. Besides, this review also revealed the lack of research on medication safety issue concerning feeding tube, further research in this area is required. / published_or_final_version / Public Health / Master / Master of Public Health
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Cellular and molecular evaluation of oral delivery systems for chemotherapeutic agentsBlanchette, James Otto, 1976- 02 August 2011 (has links)
Not available / text
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Cellular and molecular evaluation of oral delivery systems for chemotherapeutic agentsBlanchette, James Otto, Peppas, Nicholas A., January 2004 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 2004. / Supervisor: Nicholas A. Peppas. Vita. Includes bibliographical references. Also available from UMI.
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In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery systemAhmed, Iman Saad 04 September 2002 (has links)
This thesis describes evaluation of a gastric retention device (GRD)
developed at Oregon State University. The device was originally fabricated from
Xanthan gum and Locust bean gum. A modified gastric retention device
containing other additives was developed and investigated in this work. The
modified device was evaluated in vitro for swelling and dissolution properties using
riboflavin as a model drug. Different shapes and sizes of GRDs were tested in dogs
to study the gastric retention potential of these devices. The effect of the device on
food emptying from the stomach in dogs was also investigated. Endoscopic studies
in dogs also showed that the device swells rapidly and considerably in gastric fluid.
The bioavailability of riboflavin from three different size GRDs was
determined in six fasted human volunteers and compared to an immediate release
formulation. The biostudy indicated that the bioavailability of riboflavin from a
large size GRD was more than triple that measured after administration of the
immediate release formulation. Deconvolution was used to determine gastric
residence time of the different size GRDs.
A new colonic delivery system made of acetaminophen loaded beads
produced by extrusion and spheronization and coated with different ratios of pectin
and ethylcellulose coating solutions in a spray coating apparatus was also
developed in this work. Such beads release their drug content in the colon due to
susceptibility of pectin in the outer coat to enzymatic action of colonic bacteria.
The new delivery system was evaluated in vitro by conducting release studies in
different dissolution media to mimic transit times, pH and enzyme conditions in the
gastrointestinal tract. The gastrointestinal transit behavior of drug beads was also
assessed by conducting gamma-scintigraphic studies in dogs.
The bioavailability and pharmacokinetic parameters of acetaminophen from
several colonic delivery system formulations were determined in human volunteers
and compared to the immediate release commercial product Tylenol®. A selected
pectin-ethylcellulose coat formulation in the ratio 1:3 was further evaluated in six
volunteers under both fed and fasting conditions and was found to be effective and
to provide sustained drug release in the colon over a period of 12 hours. / Graduation date: 2003
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1) Development and in vivo testing of a gastric retention device (GRD) in dogs : 2) product formulations and in vitro-in vivo evaluation of a) immediate release formulation of itraconazole, b) controlled-release formulation of ketoprofen in adultsKapsi, Shivakumar G. 24 November 1998 (has links)
This thesis describes 1) development of a gastric retention device (GRD) to
increase gastric retention time of certain drugs, 2) product formulations of an immediate
release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked
carbohydrate polymers. Rate and extent of hydration of the film in water and in
simulated gastric fluid, compressibility of film, shape of the film, and in vivo gastric
transit time in the stomach of dog were used as tools to evaluate gastric retention
properties. Hydration studies were carried out at 37��C. Evaluation of the device
containing radio-opaque agents, in dogs for gastric retention was carried out with the help
of X-rays. The device was found to stay in the stomach of dogs for at least 10 hours.
GRD containing amoxicillin trihydrate caplets were evaluated in a human. The area
under the excretion rate curve was found to increase by 30% when compared to without
the device.
A successful development of a formulation of water insoluble itraconazole,
without the use of organic solvents, was achieved with modifications from eutectic
mixture techniques. Solubilization of the drug was achieved in polyethylene glycol of
higher molecular weight. A series of formulations made by varying the amounts
ingredients therein, were evaluated for dissolution profile in comparison with the
reference, Sporanox��. Effect of molecular weights of PEG and types of PEG were
evaluated for desired drug dissolution. Preliminary study from 6 subjects under the
conditions of fasting and fed indicated that bioavailability from the new formulation was
increased slightly when compared to the reference. This may be correlated to difference
in the rate of in vitro dissolution, where the new formulation has initial faster dissolution.
A controlled-release formulation of ketoprofen was also developed using a
diffusion-controlled polymer, which was coated onto the drug beads. Release of drugs
from such beads is controlled by the thickness of the coat. Thickness of the coat was
evaluated by SEM and was correlated to the desired in vitro drug release in comparison
to the reference Oruvail��. A three-way cross over study involving the new formulation
and two marketed products in 12 subjects under fasting conditions indicated that there
was a significant difference between the new product and marketed products, so as to be
considered non-bioequivalent. Use of In Vitro-In Vivo Correlations and Convolution-
Deconvolution relations predicted desired in vitro drug dissolution in a subsequent
modification of the formulation. / Graduation date: 1999
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Vehicles for the oral delivery of live bacteriaMahbubani, Krishnaa Trishna Ashok January 2013 (has links)
No description available.
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