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Syntheses of some nitrogen-bridged (2.2) cyclophanes. / Chemistry of heterocyclic compoundsJanuary 1980 (has links)
by Chan Shau-lung. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1980. / Bibliography: leaves 54-56.
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Synthesis of 2-Carbamoyl-4-Oxo-1,5-Diazabicyclo [3.2.1] Octane Derivatives as a Possible Inhibitors of Serine β-LactamasesWang, Haiyu, Shilabin, Abbas 05 April 2018 (has links)
Antibiotic resistance is becoming ever more severe due in part to the increasing use of antibiotic drugs. One significant contributor to this problem is the production of β-lactamase enzymes that provide resistance to common β-lactam antibiotics. The scope of this research is to synthesize and study the β-lactamase inhibitors of 2-carbamoyl-4-oxo-1,5-diazabicyclo [3.2.1] octane derivatives. Currently the research process is in the beginning stages of synthesizing three compounds: (R)-hexahydro-6-oxopyrimidine-4-carboxylic acid (1a), hexahydro-2,2-dimethyl-6-oxopyrimidine-4-carboxylic acid (1b) and hexahydro-6-oxo-2-phenylpyrimidine-4-carboxylic acid (1c). The future steps are to synthesize (R) -3-(methoxycarbonyl)-hexahydro-6-oxopyrimidine-4-carboxylic acid (2a), (R)-dimethyl tetrahydro-4-oxopyrimidine-1,6(2H)-dicarboxylate (3a) and (R)-methyl hexahydro-6-oxopyrimidine-4-carboxylate (4a). All the compounds will be evaluated for the inhibitory activities against pure TEM-1 and P99 β-lactamase.
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Studies on the Khand cyclisation reactionMcLaughlin, Mark January 2001 (has links)
No description available.
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An investigation of the activity and activation of clayzic and clayfec as Friedel-Crafts catalystsCullen, Stephen Ronald January 1994 (has links)
No description available.
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The enzymatic resolution of racemic enol acetates derived from prochiral oxabicyclic ketonesSwain, Simon A. January 2000 (has links)
No description available.
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Aspects of free radical cyclisationsCaddick, Stephen January 1989 (has links)
No description available.
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Heterocyclic ring synthesis using alkylidene carbene insertion reactionsBourghida, Ahmed January 2001 (has links)
No description available.
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Studies in medium ring synthesisBradley, Lisa L. January 1990 (has links)
No description available.
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Some mechanistic and synthetic aspects of carbene chemistryJeffries, I. January 1987 (has links)
No description available.
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Additions to chiral #alpha#, #beta#-epoxyiminesBeresford, Kenneth James Mcrae January 1992 (has links)
No description available.
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