A knowledge about infectious diseases and vaccination is very important in this time. The questionnaire, which is part of this thesis, is designated for 1st to 4th grade high school students and the upper grade grammar school pupils. The questionnaire was used to analyse pupils' knowledge and attitudes about infectious diseases and vaccination. Pupils' knowledge and attitudes are quite good and students are able to voice their opinion. Females have better knowledge than males and older students are better too. The thesis is further focusing on how are the infectious diseases included in the National Curriculum and examine the prevention programmes for schools. The other purpose is to follow up the threat of pandemic diseases and present state of knowledge and awareness about this topic.