Thesis (Ph.D.) - University of Queensland, 2003. / Includes bibliography.

Thesis (M.Phil.) - University of Queensland, 2005. / Includes bibliography.

No description available.

Invasive carcinoma of the cervix was compared in women under and over 35 years of age in a 10-year cohort study for the period 1974 - 1983. The aim was to determine if there were any significant differences in disease characteristics and survival. A non-concurrent prospective study design was employed with a follow-up period of at past 5 years. All eligible young patients (n = 82) were studied out of a total patient population of 1522 and compared with a 13% random sample (n = 82) of equally eligible older patients. There were three study losses in each group (3,7%), giving a final comparison number of 79. Patient data included disease stage, treatment type and complications, recurrence time and site and survival time. Tumour pathological characteristics were reviewed and evidence of Human Papillomavirus (HPV) was sought on histology and cytology specimens. Life table analyses were performed on the survival data and compared by the logrank test. The covariates of disease stage, treatment type and tumour type were included in the analysis of the effect of age group on survival. Multivariate analysis with a proportional hazards general linear model was performed for simultaneous control of confounding factors. Other disease characteristics were compared using the Chi-square test. The overall proportion of young women was 11,6%. (This did not change for the period 1984 1988.) Five-year survival was 57% for the young and 46% for the older group (not statistically significant: p = 0,198). There was no statistically significant difference in a number of characteristics, including tumour size, endocervical site, grade or type. There were 8 non-squamous tumours in the young {10%). Residual disease, time to recurrence, rate and site of distant metastasis, and treatment of recurrent tumour did not differ significantly; nor did rate of spread to lymph nodes, adequacy of follow-up or treatment complications. Evidence of HPV was found in 35% of evaluable histology and 21% of malignant cytology. There was no significant excess of HPV in the young group. The same applied to the length of the preinvasive phase and the false negative cytology rate - no significant differences were found. There were significantly more Stage lB tumours in the young group (p = 0,01), surgery was used more often for treatment in young patients (p = 0,027) and the difference in survival between the disease stages was highly significant (p 0,0001). Multivariate analysis showed that the effect of age on survival was non-significant (p = 0,850). The conclusion of the study is that cervical carcinoma in young women is not a different disease with a worse prognosis than in older women. Furthermore, it is not becoming more common in the young locally. Young women tend more often to have early stage disease.

Thesis (MPH.) -- University of Limpopo, 2020 / The South African government provides human papillomavirus (HPV) vaccination to public school girls for free. The study aimed to investigate knowledge, attitudes and practices towards HPV vaccination, of caregivers of girls aged ≥9 years in grade 4 to 7 attending private schools in South Africa. Objectives included determining levels of knowledge; describing attitudes; describing practices; and investigating levels of knowledge and attitudes of caregivers associated with HPV vaccination coverage in these girls. Turfloop Research Ethics Committee granted ethical clearance. A link to an online survey (Survey Monkey®, USA) was circulated to caregivers via an email to school principals and a Facebook advert. Epi InfoTM was used for data analysis. While 76.5% of caregivers had good knowledge about cervical cancer and HPV vaccination, 45.3% had positive attitudes towards HPV vaccination and 19.4% of the girls were vaccinated. Caregivers with good knowledge were 3.6 (95% CI: 1.6-8.0; p<0.005) times more likely to have vaccinated their daughters/wards, while caregivers with a positive attitude were 5.2 (95% CI: 2.9-9.2; p<0.05) times more likely. The low HPV vaccination uptake is concerning. Results suggest that a positive attitude towards HPV vaccination is a strong predictor of its uptake. / University of Limpopo, Anova Health Institute and National Research Foundation (NRF)

No description available.

Bibliography: leaves 159-192. / 11, 192, [58] leaves, [16] leaves of plates : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Discusses the evidence implicating papillomaviruses in the development of cervical intraepithelial neoplasia (CIN) and carcinomas and documents derivation of clones and validation of experimental procedures, epidemiological studies of ano-genital neoplasia, HPV transcription mapping in genital neoplastic lesions and cell lines, and mechanisms of tumor development. / Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1992

The ability of the HPV-18 E6 gene to impair p53-mediated transcriptional activity induced by DNA damaging agents was investigated. It is demonstrated that E6 can abolish DNA damage induced p53-mediated transcription and that a region from amino acid residue 113 to 117 of HPV-18 E6 protein was necessary for E6 to direct the degradation of p53. The biological importance of the E6/p53 interaction was then directly examined in HPV-16 containing cervical carcinoma derived cells by introducing the monomeric p53 mutant which is resistant to E6 mediated degradation. The two major observations made from this study were: (i) loss of p53 activity plays an important role in maintaining the malignant phenotype of these cells with respect to cell proliferation; (ii) the monomeric p53 mutant without its C-terminal regulatory region was biologically functional with respect to impairing cell proliferation in HPV-16 containing cervical carcinoma derived cells. Finally, it was revealed that the cellular MAP kinase signal transduction pathway was more active in cells expressing the HPV-16 E5 gene than in control cells or cells expressing E6 and E7. These observations help to define the mechanisms by which HPV oncogenes contribute to the development and maintenance of the neoplastic phenotype.

Thesis (Ph.D.)--University of Western Australia, 2005.

Thesis (M.S.)--University of Texas at El Paso, 2008. / Title from title screen. Vita. CD-ROM. Includes bibliographical references. Also available online.