Review of literature shows that rocks of all ages from the Archaean to the early Phanerozoic host pegmatite-based mineralisation in the central and southern region of the African continent. The greatest concentrations occur in the Archaean and late Proterozoic orogenic belts, while early to middle Proterozoic granites do not, in general, host mineralisation. Pan-African mineralisation is present, but is not widespread. Some deposits previously considered to be of Pan-African have been shown to be of Proterozoic age. In common with occurrences of other regions, the deposits are closely associated with small, late- to post-tectonic granites. Therefore, preliminary assessment of the potential of granites as sources of pegmatite mineralisation should utilise satellite data or aerial photographs. The granites also tend to be alkaline and peraluminous. Thus, in the next stage, chemical analysis for selected major and trace elements should be conducted directly on granites if they occur as small plutons. For large granitic batholiths or terranes, preliminary stream-sediment surveys may be necessary to reduce the size of the target area. Subsequently, pegmatite zonation around suitable granites should be assessed as it allows attention to be focussed on areas likely to host the specific type of mineralisation being explored for.