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Microchannel plate (MCP) detectors have been the detector of choice for ultraviolet (UV) instruments onboard many NASA missions. These detectors have many advantages, including high spatial resolution (<20 mu m), photon counting, radiation hardness, large formats (up to 20 cm), and ability for curved focal plane matching. Novel borosilicate glass MCPs with atomic layer deposition combine extremely low backgrounds, high strength, and tunable secondary electron yield. GaN and combinations of bialkali/alkali halide photocathodes show promise for broadband, higher quantum efficiency. Cross-strip anodes combined with compact ASIC readout electronics enable high spatial resolution over large formats with high dynamic range. The technology readiness levels of these technologies are each being advanced through research grants for laboratory testing and rocket flights. Combining these capabilities would be ideal for UV instruments onboard the Large UV/Optical/IR Surveyor (LUVOIR) and the Habitable Exoplanet Imaging Mission (HABEX) concepts currently under study for NASA's Astrophysics Decadal Survey.

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Fluorescence lifetime sensing using time correlated single photon counting (TCSPC) is a key analytical tool for molecular and cell biology research, medical diagnosis and pharmacological development. However, commercially available TCSPC equipment is bulky, expensive and power hungry, typically requiring iterative software post-processing to calculate the fluorescence lifetime. Furthermore, the technique is restrictively slow due to a low photon throughput limit which is necessary to avoid distortions caused by TCSPC pile-up. An investigation into CMOS compatible multimodule architectures to miniaturise the standard TCSPC set up, allow an increase in photon throughput by overcoming the TCSPC pile-up limit, and provide fluorescence lifetime calculations in real-time is presented. The investigation verifies the operation of the architectures and leads to the selection of optimal parameters for the number of detectors and timing channels required to overcome the TCSPC pile-up limit by at least an order of magnitude. The parameters are used to implement a low power miniaturised sensor in a 130 nm CMOS process, combining single photon detection, multiple channel timing and embedded pre-processing of the fluorescence lifetime, all within a silicon area of < 2 mm2. Single photon detection is achieved using an array of single photon avalanche diodes (SPADs) arranged in a digital silicon photomultiplier (SiPM) architecture with a 10 % fill-factor and a compressed 250 ps output pulse, which provides a photon throughput of > 700 MHz. An array of time-interleaved time-to-digital converters (TI-TDCs) with 50 ps resolution and no processing dead-time records up to eight photon events during each excitation period, significantly reducing the effect of TCSPC pile-up. The TCSPC data is then processed using an embedded centre-of-mass method (CMM) pre-calculation to produce single exponential fluorescence lifetime estimations in real-time. The combination of high photon throughput and real-time calculation enables advances in applications such as fluorescence lifetime imaging microscopy (FLIM) and time domain fluorescence lifetime activated cell sorting. To demonstrate this, the device is validated in practical bulk sample fluorescence lifetime, FLIM and simulated flow based experiments. Photon throughputs in excess of the excitation frequency are demonstrated for a range of organic and inorganic fluorophores for minimal error in lifetime calculation by CMM (< 5 %).

A novel photon flux monitor has been designed and tested for use at the Duke University High Intensity Gamma Source, where the photon beam produced is essentially mono-energetic but it is not tagged. Direct counting of the number of photons using a high-efficiency detector is not possible because of the high photon fluxes expected. Therefore, a direct counting detector with a low, accurately known efficiency was required.<p> The photon flux monitor based on a five scintillator paddle system detects recoil electrons and positrons from photoelectric, Compton and pair-production processes. It has been designed to be insensitive to gain and detector threshold changes and to be usable for photon energies above 5 MeV. It has been calibrated using direct counting with a NaI detector and its efficiency has been shown to be well predicted by a GEANT4 simulation.<p> Results of measurements, calibration and calculations required to characterize the 5-paddle photon flux monitor are presented. The photon flux monitor has met its design specifications of being able to determine the number of photons incident on it during the live time of a measurement to within a systematic error of 2%.<p> A paper based on the work for this thesis has been published in the Nuclear Instruments and Methods in Physics Research Journal.

Dual energy imaging has made it possible to enhance contrast in medical images using images containing different energy information, by combining low and high energy images. Dual energy data can either be acquired using double exposures or splitting the energy spectrum into two images using one exposure. This thesis presents investigations of dual energy imaging using a detector solution developed by XCounter which provides dual energy images in a single exposure with a threshold separating low and high energy images. Phantom experiments with phantoms of aluminum and plexiglas were performed using weighted logarithmic subtraction and basis material decomposition to produce dual energy images. Methods were validated and images were evaluated in terms of signal difference in noise ratio to find the threshold and tube voltage combination for optimum energy spectrum separation. The methods were also tested on biological materials using bone, soft tissue and iodine solution as contrast enhancer, to investigate K-edge imaging.  Optimal separation of plexiglas and aluminum were found at 70 kVp and the threshold parameter set within a range of 8 to 9, which corresponds to approximately 30 to 34 keV. For K-edge imaging, the optimum separation were found close to K-edge energy of iodine. The results found in the phantom study correlated with results from the biological material study.

A novel photon flux monitor has been designed and tested for use at the Duke University High Intensity Gamma Source, where the photon beam produced is essentially mono-energetic but it is not tagged. Direct counting of the number of photons using a high-efficiency detector is not possible because of the high photon fluxes expected. Therefore, a direct counting detector with a low, accurately known efficiency was required.<p> The photon flux monitor based on a five scintillator paddle system detects recoil electrons and positrons from photoelectric, Compton and pair-production processes. It has been designed to be insensitive to gain and detector threshold changes and to be usable for photon energies above 5 MeV. It has been calibrated using direct counting with a NaI detector and its efficiency has been shown to be well predicted by a GEANT4 simulation.<p> Results of measurements, calibration and calculations required to characterize the 5-paddle photon flux monitor are presented. The photon flux monitor has met its design specifications of being able to determine the number of photons incident on it during the live time of a measurement to within a systematic error of 2%.<p> A paper based on the work for this thesis has been published in the Nuclear Instruments and Methods in Physics Research Journal.

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Fiber-optic Bragg grating (FBG) sensors are a very attractive technology for the measurement of strain and temperature. They have many advantages over conventional sensors in sensing applications such as sensitivity, immunity to electromagnetic interferences,large bandwidths,capability of remote operation and the potential power to sense micro strain at high temperature. They can be directly embedded into many structures such as concrete to evaluate the material deformation. FBGs are fabricated by photo-inscribing through a phase mask technology on a photosensitive fiber. A periodic refractive index is formed in the fiber core, introducing a reflection at the Bragg wavelength. Since the FBG is characterized by a low insertion loss and controllable reflectance, it has the potential to be multiplexed in very large numbers. The major purpose of this dissertation research is to develop an innovative, high- resolution fiber Bragg grating sensing system using photon-counting optical time domain reflectometry (pc-OTDR) based multiplexing technology. The system uses a Fresnel reflection OTDR with a zero deadzone to detect FBG sensors, which improves both the system detection ability and spatial resolution. A low reflectance FBG with broad bandwidth has been developed that is appropriate for the pc-OTDR measurement. Hundred of multiplexed sensors have been implemented in this system. Two theoretical analyses and preliminary results are presented. The greatest advantage of the system is to increase the maximum multiplexing sensor number to one thousand within a short fiber range. Self-referencing demodulation is necessary to eliminate multiplexed system noise caused by the source power fluctuation and fiber bending effects. A referencing FBG with a different wavelength from the sensing FBG has to be introduced to achieve compensation of disturbances in the measurement. The spectral properties of the FBGs and the combination of WDM/TDM are also discussed to evaluate multiplexing sensor performance. The sensor crosstalk and other noise performances are assessed to evaluate the possibility of large scale multiplexing. / Ph. D.