• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 101
  • 59
  • 39
  • 16
  • 7
  • 6
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • Tagged with
  • 279
  • 36
  • 33
  • 30
  • 25
  • 25
  • 23
  • 21
  • 20
  • 17
  • 15
  • 15
  • 15
  • 14
  • 14
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Polymeranalytische Charakterisierung mittels Grössenausschlusschromatographie, Fluss-Feld-Fluss-Fraktionierung und Lichtstreuung von Polysaccharid-Derivaten

Gosch, Carola I. January 2002 (has links) (PDF)
Hamburg, Univ., Diss., 2002. / Computerdatei im Fernzugriff.
2

Polymeranalytische Charakterisierung mittels Grössenausschlusschromatographie, Fluss-Feld-Fluss-Fraktionierung und Lichtstreuung von Polysaccharid-Derivaten

Gosch, Carola I. January 2002 (has links) (PDF)
Hamburg, Univ., Diss., 2002. / Computerdatei im Fernzugriff.
3

Analytik von wasserlöslichen Polysacchariden und Polysaccharidderivaten mittels Grössenausschlusschromatographie kombiniert mit Vielwinkellaserlichtstreuung und Konzentrationsdetektion

Pfefferkorn, Pascal M. J. January 2004 (has links) (PDF)
Hamburg, Universiẗat, Diss., 2004.
4

Polymeranalytische Charakterisierung mittels Grössenausschlusschromatographie, Fluss-Feld-Fluss-Fraktionierung und Lichtstreuung von Polysaccharid-Derivaten

Gosch, Carola. January 2002 (has links) (PDF)
Hamburg, Universiẗat, Diss., 2002.
5

The expression, purification and characterisation of hyaluronan-binding domains from extracellular matrix proteins

McVey, Gillian January 2002 (has links)
No description available.
6

Synthesis of the repeating unit of Streptococcus pneumoniae (Sp1) zwitterionic polysaccharide

Iynkkaran, Ithayavani 11 1900 (has links)
According to the traditional paradigm, carbohydrates are considered to be poorly immunogenic, T-cell independent antigens. Pure polysaccharides induce specific IgM responses, with minimal class switch to IgG. However, a series of recent investigations has found that a class of zwitterionic polysaccharides (ZPSs)induces a variety of T-cell specific responses such as cell proliferation,cytokine secretion, and regulation of antibody production. The two most studied among this family of molecules is capsular polysaccharide (PS) A1 from the Bacteroides fragilis and the type 1 Streptococcus pneumoniae polysaccharide capsule (Sp1). Active ZPSs share a common structural motif; a high density of positively charged amino and negatively charged carboxyl or phosphate groups. These features are essential for the activity of ZPSs. Since the biological repeating unit of the polysaccharides is not known and biological activity will most likely depend upon a precise sequence, synthesis of the repeating unit of these capsular polysaccharides was undertaken. The goal of this work is to synthesize the repeating unit [3)--DFucpN2AcN4-( 14)--D-GalpA-(13)--D-GalpA-(1] of the type 1 capsular polysaccharide (Sp1) found in S. pneumoniae. 2-Acetamido-4-amino-2,4,6- trideoxy-D-galactopyranose is one of the three monosaccharides of the repeating unit of the Sp1 of Streptococcus pneumoniae. This rare amino sugar is also present in a number of bacterial polysaccharides such as Bacteroids fragilis, Streptococcus mitis and Shigella sonnei. We have developed a novel method to synthesize the orthogonally protected 2-acetamido-4-amino-2,4,6-trideoxy-Dgalactopyranose on a gram scale with high yield starting from readily available Dglucal. The crucial elements of this approach are the introduction of a 4 amino function via intramolecular cyclization of a 3-O-N-benzylcarbamate. The resulting N-benzyloxazolidinone derivative after conversion to the corresponding glycosyl trichloroacetimidate was shown to be an effective glycosyl donor. The assembly of the trisaccharide was successfully carried out from the appropriate galactopyranosides selectively protected at O-6 to permit oxidation to uronic acid derivatives after successful assembly of the target trisaccharide. The trisaccharide was tested for its ability to stimulate interleukin 10 (IL-10) and Interferon-gamma (IFN-) in collaboration with Dr. Dennis L. Kasper (Channing Laboratory, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA). Unfortunately the trisaccharide was not active. / Chemistry
7

Polymeric Plant-derived Excipients in Drug Delivery

Beneke, CE, Viljoen, AM, Hamman, JH 16 July 2009 (has links)
Abstract: Drug dosage forms contain many components in addition to the active pharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise drug delivery. Due to advances in drug delivery technology, excipients are currently included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and absorption. Since plant polysaccharides comply with many requirements expected of pharmaceutical excipients such as non-toxicity, stability, availability and renewability they are extensively investigated for use in the development of solid oral dosage forms. Furthermore, polysaccharides with varying physicochemical properties can be extracted from plants at relatively low cost and can be chemically modified to suit specific needs. As an example, many polysaccharide-rich plant materials are successfully used as matrix formers in modified release dosage forms. Some natural polysaccharides have even shown environmental-responsive gelation characteristics with the potential to control drug release according to specific therapeutic needs. This review discusses some of the most important plant-derived polymeric compounds that are used or investigated as excipients in drug delivery systems.
8

Synthesis of the repeating unit of Streptococcus pneumoniae (Sp1) zwitterionic polysaccharide

Iynkkaran, Ithayavani Unknown Date
No description available.
9

Physiology of Sialic Acid Capsular Polysaccharide Synthesis in Serogroup B Neisseria Meningitidis

Masson, Luke 08 1900 (has links)
No description available.
10

Soluble silica and aluminium bioavailability

Jugdaohsingh, Ravin January 2000 (has links)
No description available.

Page generated in 0.0711 seconds