The porous materials discussed in this dissertation are metal-organic frameworks (MOFs) and porous liquids. Due to their high surface areas, tunable structures, and controllable porosities, MOFs have been explored for a wide variety of drug delivery applications. In chapter 2, MOFs have been used as magnetothermal-triggered release carriers through spatially distributed iron oxide nanoparticles within MOF matrix as a magnetic heating mediator and surface-grafted thermal-responsive nanocap as an alternating magnetic field (AMF)-responsive gatekeepers, achieving monitoring of drug release via external AMF by a conformational change of nanocap. In chapter 3, MOF, as a non-toxic loading carrier, encapsulate naringin, a natural product to serve as a multifunctional bio-platform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through the synergies between naringin and MOF. In chapter 4, porous liquid with unique solvent-free fluidity properties as a drug delivery platform for the first time. The interaction between hollow silica nanoparticle and polymerized ionic liquid, followed by ionic grafting brush of poly (ethylene glycol) telomer, makes this designed porous liquid responsible for high drug-loading and pH-responsive drug-releasing abilities along with slow degradation behavior. In addition to their high loading and controlled release, In vitro cell viability and cell uptake are also studied, thus opening up new opportunities for long-term chemotherapy.