Perfectionism has long been recognized as an important personality trait that has a significant impact on emotional and social well-being. More recently, it has been recognized that there is a stylistic aspect to perfectionism that focuses on a desire to appear perfect. This perfectionistic self-presentation, and in particular, the desire for concealment of imperfections, has been related to psychopathology in past research. However, it is proposed that perfectionistic self-presentation presents a particular concern from a clinical perspective because of it's indirect effects on pathology; a desire to conceal imperfections is especially problematic to the extent that it impacts the experience of therapy and the therapy relationship. The current study examined the cognitive, affective/physiological, and behavioral manifestations of perfectionistic self-presentation in a clinical sample. Ninety clinical subjects completed self-report measures of perfectionistic self-presentation, trait perfectionism, impression management, mood, appraisals, and self-handicapping. A brief structured assessment interview that included a discussion of past mistakes, was conducted by trained clinical interviewers. Physiological monitors recorded heart rate and skin conductance level throughout the interview, and the interview was videotaped. Post-interview measures of mood, appraisals, and self-handicapping, were also completed. Results at the bivariate level showed that the self-protective dimensions of perfectionistic self-presentation were associated with more distress both prior to and following the interview, higher heart rate and greater change in heart rate when discussing mistakes (and greater skin conductance for men), greater claims of disability from self-handicaps, and appraisals of the interviewer as both threatening (wanting more than the participant could provide) and disappointed following the interview. Regression analyses showed that the desire to avoid disclosing imperfections was a unique predictor of appraisals of threat over and above demographics, trait perfectionism, and other measures of distress (interaction anxiety and depression) and impression management, and of appraisals of the interviewer as disappointed following the interview, over and above demographics and trait perfectionism. The block change score for perfectionistic self-presentation predicting interviewer satisfaction was marginally significant over and above emotional distress and impression managment. The desire to avoid displaying imperfections was a unique predictor of lower threat appraisals. Perfectionistic self-presentation also predicted higher heart rate when discussing errors, over and above demographics and other measures of distress and impression management, and greater change in heart rate from relaxation; this relation held when controlling for demographics, trait perfectionism, and emotional distress and impression management. Perfectionistic self-presentation did not predict defensive behaviors and was not a unique predictor of self-reported negative affect. The results are discussed in terms of the implications for therapy and the therapeutic alliance.

This dissertation formulates a poetics of performance in nonfiction film and television. Building on a large body of converging research that calls for an acknowledgment of: the constructedness of documentary texts; the performative nature of identity; and the significance of screen performance, I illustrate the way in which documentary subjects must finally be seen as creative agents who (consciously or not) play a significant role in determining the meanings, functions, and effects of the films in which they appear. A first chapter lays the groundwork for this discussion, setting out a means of understanding and investigating the documentary performer’s work. It is argued that nonfiction performance is a three-tiered process, wherein everyday performative activity (tier #1) is shaped by and often tailored to the camera (tier #2) within specific nonfiction film frameworks (tier #3). In addition to providing a flexible and generally applicable model of what the nonfiction subject’s work entails, this conceptualization suggests an appropriate means of analysing individual documentary performances, indicating the necessity of attending to the way in which twice modified everyday self-presentational tools serve as signifiers in any given nonfiction text. Subsequent chapters turn from the issue of what nonfiction performance involves to a consideration of what it accomplishes. Drawing from scholarship devoted to each of the three levels of the documentary ‘social actor’s’ work, I posit three major functions for nonfiction performance. Chapter 2 demonstrates the way in which the individuals who appear in documentaries play a significant role in the construction of ‘characters’, which, in turn, exert an indelible influence on the meaning(s) of the texts in which they figure. Chapter 3 argues that nonfiction performance helps to bolster and/or to destabilize normative understandings of identity categories such as gender, sexuality, age, ethnicity, race, class and dis/ability. Finally, the concluding chapter discusses the way in which documentary performers help to invite affective reactions from spectators, and – in so doing – contribute significantly to nonfiction texts’ ability to effectuate social change. Detailed analyses of a wide range of documentaries provide support for these contentions.

Purpose: To describe patient & tumor characteristics among rectal cancer patients in Nova Scotia, to determine factors associated with permanent colostomy and oncologic outcomes and to determine the relationship between surgeon knowledge and oncologic outcomes.Methods:The Provincial cancer registry identified new rectal cancer patients from in Nova Scotia. A comprehensive review of inpatient, outpatient and cancer center medical records was used to assemble the cohort. Surgeon knowledge was assessed using a survey with questions pertaining to rectal cancer care.Results: Patient & tumor characteristics were similar between hospitals providing rectal cancer care. Patients treated by high volume cancer center surgeons are less likely to undergo a permanent colostomy or have a local recurrence compared to patients treated elsewhere. Patients treated by surgeons with a high survey score have improved clinical and oncologic outcomes.Conclusions: There is an opportunity to improve rectal cancer care in Nova Scotia.

During viral infections, CD8+ T cells only respond to a select few epitopes derived from the respective foreign pathogen. These epitopes can be organized into a hierarchy, based on their ability to induce T cell priming. Such phenomenon is known as immunodominance. Cytotoxic T cells can be primed through the direct pathway, or the cross-priming pathway. The latter involves exogenously derived viral epitope presentation by uninfected professional antigen presenting cells. It has been previously reported that Lymphocytic Choriomeningitis nucleoprotein expressed in HEK cells (HEK-NP) could be cross presented to CD8+ T cells. In these studies we have used this same HEK-NP model to study the effects of LCMV-NP cross priming on the LCMV immunodominance hierarchy following viral challenge. Our results provide strong evidence that cross priming is an efficient route with which to induce cell-mediated immunity. We also highlight a regulatory role for cross priming in immunodominance by showing that a single dose of HEK-NP can completely shift the immunodominance hierarchy of a typical LCMV infection. Furthermore, we see that the induction of LCMV-NP cross priming boosts anti-viral immunity to subsequent LCMV infections. This work provides strong support for the physiological role that cross priming plays in normal cell-mediated immune responses. It may also provide relevant information to the realm of immunotherapy. / Thesis (Master, Microbiology & Immunology) -- Queen's University, 2007-07-10 14:33:18.115

Digital libraries (DLs) represent an important evolutionary step towards accessing structured digital information. DLs are often built from scratch or by using proprietary monolithic software that is often difficult to customise and extend to meet changing requirements. Researchers are beginning to realise that this is not an ideal solution and as a result, are creating component suites and accompanying protocols to encourage the creation of modular DLs. Despite the introduction of component models, it is not immediately apparent how they can be seamlessly assembled to produce diverse, yet fully functional, component-based digital library systems without knowledge of the underlying protocols. This dissertation presents a graphical user interface and its associated framework for creating DL systems from distributed components, consequently shielding DL architects from the complexity of using components models and taking advantage of the inherent benefits of the component programming paradigm. The framework introduced in this dissertation was designed to be generic enough to be adopted for the assembly of a variety of component-based systems over and beyond the digital library community. After being tested on over thirty inexperienced users and modelling a number of existing DL systems, graphically assembling distributed components has been shown to be a viable approach to simplify the creation of modular DLs from a pool of heterogeneous components.

Music Information Retrieval (MlR) is the interdisciplinary science of retrieving information from music and includes influences from different areas, like music perception and cognition, music analysis, signal processing, music indexing and information retrieval [Futrelle & Downie, 2003]. To produce the most efficient MlR systems, test-beds are commonly used to test different combinations of parameters against each other. The purpose of this dissertation was to investigate the composition of algorithms for MlR systems by constructing an interface that could form part of a test-bed. It differs from other interfaces and frameworks that are used in MlR test-beds because it is focused on small scale test-beds. MIRMaid is an acronym for Music Information Retrieval Modular aid and is an interface that allows different content based retrieval tasks to be compared against each other to find optimal combinations of retrieval parameters for specialised problem domains. The dissertation describes the process of how the MIRMaid interface was developed, modified and refined. A big challenge was to design the user experiments in a way that considered potential users of the interface while using the test subjects I had at my disposal. I decided to use the simplest queries to highlight basic similarities between novice and potential expert users. The performance of the interface was judged by user ratings on a questionnaire. The interface performed reasonably well with expert users and novice users. Despite these results there were a few interesting observations that were returned from the user experiments related to the experiment design and the task explanations. Some suggestions are also provided for extending the interface to allow it to be used with other types of data. The possibility is also investigated for using the interface as a tool for simplifying the process of integrating modules from different sources.

This dissertation formulates a poetics of performance in nonfiction film and television. Building on a large body of converging research that calls for an acknowledgment of: the constructedness of documentary texts; the performative nature of identity; and the significance of screen performance, I illustrate the way in which documentary subjects must finally be seen as creative agents who (consciously or not) play a significant role in determining the meanings, functions, and effects of the films in which they appear. A first chapter lays the groundwork for this discussion, setting out a means of understanding and investigating the documentary performer’s work. It is argued that nonfiction performance is a three-tiered process, wherein everyday performative activity (tier #1) is shaped by and often tailored to the camera (tier #2) within specific nonfiction film frameworks (tier #3). In addition to providing a flexible and generally applicable model of what the nonfiction subject’s work entails, this conceptualization suggests an appropriate means of analysing individual documentary performances, indicating the necessity of attending to the way in which twice modified everyday self-presentational tools serve as signifiers in any given nonfiction text. Subsequent chapters turn from the issue of what nonfiction performance involves to a consideration of what it accomplishes. Drawing from scholarship devoted to each of the three levels of the documentary ‘social actor’s’ work, I posit three major functions for nonfiction performance. Chapter 2 demonstrates the way in which the individuals who appear in documentaries play a significant role in the construction of ‘characters’, which, in turn, exert an indelible influence on the meaning(s) of the texts in which they figure. Chapter 3 argues that nonfiction performance helps to bolster and/or to destabilize normative understandings of identity categories such as gender, sexuality, age, ethnicity, race, class and dis/ability. Finally, the concluding chapter discusses the way in which documentary performers help to invite affective reactions from spectators, and – in so doing – contribute significantly to nonfiction texts’ ability to effectuate social change. Detailed analyses of a wide range of documentaries provide support for these contentions.

Impression management (IM) handlar om enmedveten eller omedveten process att styra intrycken av sig själv som ges tillomgivningen i syfte att imponera och söka erkännande. Tidigare forskning har istor utsträckning berört anställningsrekommendation utifrån intervjuer och demest framgångsrika resultaten har visat sig vara självförbättrande IM taktik.Studiens syfte vara att undersöka hur självförbättrande IM taktik i personligtbrev, två kvalitéer av meriter, påverkar ett beslut omanställningsrekommendation, samt undersöka hur en uppsättning personliga egenskaperrelaterar till självförbättrande IM taktik. Deltagarna var studenter, 57kvinnor och 32 män. Studien var experimentell 2 x 2 x 2 mellangruppsdesign. Deviktigaste fynden var att, högre kvalité av meriter innebar högre skattning avanställningsrekommendation samt att högre skattning av egenskaper vidsjälvförbättrande IM taktik skattats. Meriters kvalité visades viktig,egenskaper visade samband med IM dock satte IM trovärdighet på spel.Könsskillnader påträffades även och vidare forskning förslås göras mellankönen.

Systems to annotate online content are becoming increasingly common on the World Wide Web. While much research and development has been done for interfaces that allow users to make and view annotations, few annotation systems provide functionality that extends beyond this and allows users to also manage and process collections of existing annotations. Siyavula Education is a social enterprise that publishes high school Maths and Science textbooks online. The company uses annotations to collate collaborator and volunteer feedback (corrections, opinions, suggestions) about its books at various phases in the book-writing life cycle. Currently the company captures annotations on PDF versions of their books. The web-based software they use allows for some filtering and sorting of existing annotations, but the system is limited and not ideal for their rather specialised requirements. In an attempt to move away from a proprietary, PDF-based system Siyavula implemented annotator (http://okfnlabs.org/annotator/), software which allowed for the annotation of HTML pages. However, this software was not coupled with a back-end interface that would allow users to interact with a database of saved annotations. To enable this kind of interaction, a prototype interface was designed and is presented here. The purpose of the interface was to give users new and improved functionality for querying and manipulating a collection of web-based annotations about Siyavula’s online content. Usability tests demonstrated that the interface was successful at giving users this new and necessary functionality (including filtering, sorting and searching) to process annotations. Once integrated with front-end software (such as Annotator) and issue tracking software (such as GitHub) the interface could form part of a powerful new tool for the making and management of annotations on the Web.

Ankylosing spondylitis (AS) is associated with HLA-B*2704 and B*2705 but not with HLA-B*2706 and B*2709. Genome wide studies recently identified ERAP1 as an important genetic association in AS and could be the missing link in the pathogenesis of AS. I studied the implications of the two known actions of ERAP1 on AS pathogenesis. For assessing the peptide trimming function, surface HLA-B27 and MHC-I free heavy chain (FHC) expression on peripheral blood mononuclear cells of AS patients were studied. Subsequently, in an in vitro system of C1R cells expressing different AS-associated and AS-neutral HLA-B27 subtypes, I studied the effect of ERAP1 suppression on HLA-B27 and FHC expression. To assess the cytokine receptor shedding function, I studied serum cytokine receptor level variation with ERAP1 polymorphisms and its relationship to disease activity in AS patients. Finally, I studied the effect of variants of ERAP1 and other members of the antigen presentation machinery on radiographic severity in AS patients. AS patients with the major allele of the ERAP1 rs27044 polymorphism had higher FHC expression on monocytes. In C1R cells ERAP1 suppression led to an increase in intracellular FHC (IC-FHC) and B27-peptide complexes identified by a special MARB4 antibody, but only in C1R cells expressing the AS-associated subtypes HLA-B*2704 and B*2705. ERAP1 variants had no effect on serum cytokine receptor levels. Baseline radiographic severity was associated with ERAP1 polymorphism in univariate analysis only. LMP2 variants were associated with baseline radiographic severity in multivariate analysis. ERAP1 affects peptide presentation and FHC formation by HLA-B27 and could be the missing link in the pathogenesis of AS. ERAP1 through its differential HLA-B27 subtype interaction could explain why certain subtypes of HLA-B27 are associated with AS while others are not. Larger studies are required to look closely at the effect of ERAP1 on radiographic severity and progression in AS.