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41	Recombinant expression and full backbone assignment of the human DWNN using heteronuclear NMR Faro, Andrew January 2005 (has links) Magister Scientiae - MSc / The cellular levels of a number of proteins have been found to be regulated by the ubiquitin-proteasome pathway. In this pathway, proteins are covalently tagged (“ubiquitinated”) by ubiquitin, which acts as a signal for degradation by the proteasome. A number of key cellular processes, including cell-cycle progression, transcription and DNA repair, are regulated in this way. In recent years a number of cellular proteins resembling ubiquitin in structure or function, the so-called ubiquitin-like proteins, have been identified. Ubiquitin-like proteins can be divided into two classes-the so-called “ubiquitin-like modifiers”, which consist of a single domain that structurally resembles ubiquitin, and “ubiquitin-domain” proteins, which are multi-domain proteins, which include domains that resemble ubiquitin. This thesis describes the recombinant expression, purification and full backbone assignment of the human DWNN domain, a novel ubiquitin-like domain. The DWNN domain occurs at the N-terminus of RBBP6, a protein that has been shown to interact with p53 and Rb as well as to be involved in mRNA processing and apoptosis. A bacterial expression system was used to overexpress the DWNN domain as a GST fusion protein. The domain was labelled with 15N and 13C to perform triple-resonance heteronuclear NMR experiments, from which full backbone assignments were obtained. Although full structure determination of the DWNN domain falls outside the scope of this thesis, the backbone assignments formed the basis for the subsequent structure determination, which confirmed that the DWNN domain is indeed a novel ubiquitin-like domain. The RBBP6 protein may therefore represent a novel E3 ubiquitin ligase that plays a role in regulating the cellular levels of p53 and Rb. / South Africa Ubiquitin Proteolytic enzymes
42	Pectic enzyme and protease production in Erwinia carotovora subsp. atroseptica / George, Helga L. 01 January 1987 (has links) (PDF) No description available. Potato-rot Proteolytic enzymes.
43	Physiological regulation of Streptomycete Proteases / Gibb, Gregory Donald January 1987 (has links) No description available. Biology Proteolytic enzymes Streptomyces
44	An investigation of the plasminogen activator system in human oesophageal and gastric carcinoma Hewin, David Fitzgerald January 2000 (has links) No description available. 610
45	Detection of type IV collagen degradation in inflammatory bowel disease Wheatcroft, Alison Clare January 1999 (has links) No description available. 610
46	Design, synthesis, and evaluation of novel irreversible inhibitors for caspases Ekici, Özlem Doğan, January 2003 (has links) (PDF) Thesis (Ph. D.)--School of Chemistry and Biochemistry, Georgia Institute of Technology, 2004. Directed by James C. Powers. / Vita. Includes bibliographical references (leaves 132-151).
47	Proteolytic enzyme in soy sauce fermentation Chan, Chun, Jade. January 2001 (has links) Thesis (M. Phil.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 55-61).
48	Proteolytic enzyme in soy sauce fermentation 陳臻, Chan, Chun, Jade. January 2001 (has links) published_or_final_version / Zoology / Master / Master of Philosophy Proteolytic enzymes. Soy sauce. Fermentation.
49	The molecular interactions and mechanisms of intramembrane-cleaving aspartyl proteases Lu, Stephen Hsueh-Jeng January 2012 (has links) No description available. 612.8 Membrane proteins ; Proteolytic enzymes
50	Synthesis and evaluation of fluorescent and biotinylated derivatives of diphenyl peptidylphosphonate esters and biotinylated isocoumarins as inhibitors of serine proteases Abuelyaman, Ahmed Salih 08 1900 (has links) No description available. Biphenyl compounds Esters Proteolytic enzymes

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