Cette thèse traite un sujet pluridisciplinaire, la conception d’un prototype de micro-capteur biologique pour la détection des anticorps de patients susceptibles d'être allergiques.Elle a pour objectif la miniaturisation de la méthode ELISA pour « Enzyme Linked Immune Sorbent Assay » en concevant en « full-custom », avec une technologie CMOS APS, un capteur colorimétrique. Ce capteur est posé en dessous un système micro fluidique contenant l’échantillon biologique à tester, le tout est illuminé via une fibre optique. Le détecteur capte la lumière qui a traversé le micro-tube contenant l’échantillon. Les courants photoniques induits sont liés à la concentration et la coloration de la solution. Le virage colorimétrique de la réaction enzymatique, due à la présence des anticorps dans le sérum, et l’évaluation quantitative de la concentration seront déterminée par la mesure de ces photo-courants. Le capteur pourrait contenir une matrice de 20x20 pixels de détecteurs de couleur ainsi que leur électronique de lecture et de commande. Pour des raisons de coûts, nous avons validé le procédé à l’aide d’une matrice de 4x4 pixels de détecteur de couleur. La réalisation du circuit a été suivie par une caractérisation électrique et colorimétrique. La caractérisation électrique a permis de valider le fonctionnement du bloc de commande du circuit ainsi que celui du pixel (l’électronique de lecture, BDJ). Les résultats de mesures concordent avec ceux de simulations. La caractérisation colorimétrique consiste à mesurer le virage colorimétrique de deux solutions différentes. Les mesures ont pu montrer que notre capteur est plus sensible que le spectromètre utilisé pour mesurer la concentration des deux solutions. Ainsi ce travail de recherche a contribué à la miniaturisation d’une bio-puce colorimétrique dédiée aux tests immunologiques basée sur la méthode ELISA. / This PhD treats a multidisciplinary subject based on the design of a biological micro-sensor prototype for the detection of antibodies of patients susceptible to be allergic.The goal has been the miniaturization of the ELISA "Enzyme Linked Immune Sorbent Assay" method, designing in integrated full-custom colorimetric sensor with a CMOS APS technology. This sensor is installed below a microfluidic system containing the biological test sample, the whole is illuminated via an optical fiber. The sensor detects the light passed through the micro reservoir containing the sample, the induced photo-currents is related to the concentration of the solution. The color change of the enzyme reaction due to the presence of antibodies in the serum, and the quantitative evaluation of the concentration will be determined by the measurement of the induced photo-currents. The sensor may contain a matrix of 20x20 color detector pixels and their reading and control electronics. For cost reasons, we validated the method using a matrix of 4 x 4 pixels of color detectors.The design of electrical device was followed by a colorimetric and electrical characterizations. The latter was used to validate the operation of the control block of the circuit as well as that of the pixel (readout electronics, BDJ). The results brought by measurements are in good agreement with those obtained through simulations. The colorimetric characterization consists in measuring the intensity of the color of two different solutions of different colors. These measurements have shown that our sensor is more sensitive than a spectrometer. Therefore, this research work has contributed to the miniaturization of a colorimetric sensor and its electronic part for the Immunoassay based on the ELISA method.

The late Neolithic of North Mesopotamia has long been held up as the first example of a ‘global’ culture with aspects of shared material culture, most notably pottery styles and subsistence strategies, spread across North Mesopotamia, the Northern Levant, and parts of south-east Anatolia. Increasing research in the past twenty years has illustrated that the material similarities visible in the late Neolithic do not represent a closed cultural community, but instead reflect a network of loosely connected groups who were members of imagined communities that linked people within shared cosmologies. Since their discovery in the early decades of the twentieth century stamp seals have been treated as a type artefact of the late Neolithic (particularly one of its constituent parts the Halaf) where they have been used to argue for the presence of sealing systems based around administrative storage of personal or communal property and possibly trade relations. However, except for a thesis published in 1990, late Neolithic stamp seals have never been comprehensively studied or interpreted primarily within their own context. Instead previous studies of stamp seals have tied stamp seals into a modernist narrative of progression that implicitly culminates in modern, Western, Nation States. This research challenges and deconstructs this narrative to demonstrate there is little evidence that seals in the late Neolithic were used for administrative purposes. To this end it gathered and re-classified the available data on provenanced stamp seals using a classificatory ontology called prototype theory that allows for more reflexive classification then the existing Aristotelian classifications. The thesis argues that stamp seals were indexical symbols with their symbolism being used to link members of imagined communities within real communities across the late Neolithic ‘world’. These people were members of a perceived descent group originating in shifting relationships to place during the change from sedentary farming communities in the eighth millennium BC to more mobile communities in the seventh millennium BC. At the same time as negotiating these supra-community identities seals were also used indexically in a variety of sub-community ways being used for a variety of magical (primarily apotropaic and talismanic) uses. As part of this I argue sealing practices in the late Neolithic relate to specific events of efficacious sealing using the power in the seal’s design.

Gamification har börjat integreras mer och mer i våra liv varje år inom diverse områden såsom shopping, sport och undervisning. Gamification används per definition för att öka motivation hos användare genom att introducera spelmoment i en icke-spel kontext. Denna studie syftar till att utvärdera hur bra de designprinciper och designriktlinjer, som är formade utifrån ett ramverk som kallas för MDA-ramverket (ett ramverk inom gamification), kan tillämpas vid utformningen av en gamificationapplikation inom kontexten av ett biobesök eller om det krävs en modifiering av dessa. Studien syftar även till att ta reda på huruvida den här typen av applikation skulle kunna öka det generella intresset för att bli medlem hos en bioverksamhet likt Filmstaden. För att ta reda på detta gjordes en intervju som en del av förstudien för att kontrollera den generella attityden och intresset för en applikation som denna. MDA-ramverket användes sedan till att utveckla en Lo-Fi prototyp utifrån principerna och riktlinjerna inom MDA-ramverket. Denna prototyp testades genom att observera totalt tio användare som fick interagera fritt med prototypens olika funktioner. Observationen följdes upp av en intervju med samma användare som fick uttrycka sina känslor gentemot applikationen och de potentiella problem som uppkom med den. Analysen av observationen samt svaren från respondenterna jämfördes sedan med principerna och riktlinjerna som användes under designfasen för att se hur väl dessa kunde tillämpas i kontexten av ett biobesök eller om de kunde ses som felaktiga. Resultatet av studien visade på att de flesta riktlinjer var essentiella för kvalitén av prototypen men att några av dem borde ses över vid utvecklingen av en gamificationapplikation i kontexten av ett biobesök. Slutligen visade också studien, baserat på intervjusvaren som samlades in, att en applikation som denna skulle kunna öka motivation bland biobesökare att bli medlem i Filmstadens bioklubb. / Gamification has been increasingly integrated into our lives every year within different areas such as shopping, sports and education. It focuses by definition on increasing the motivation in users by introducing gaming elements into a non-gaming context. This paper aims to investigate how well current design principles and design guidelines, that have been shaped from the so-called MDA-framework (a framework within gamification), can be used for designing a gamification application within the context of a cinematic experience or if modification is required. It also investigates whether this sort of application would be able to increase the general interest of becoming a member at a cinema enterprise such as Filmstaden, Sweden. First of all, an interview was constructed as part of the pre-study to check the general attitude and interest toward an application like this. An existing framework for gamification called the MDA-framework was then used to create a Lo-Fi prototype that practices the principles and guidelines of MDA for an optimal design. This prototype was then tested by observing a total of 10 users who got to interact freely with the different functions. This observation was followed by an interview with the same users where they got to express their feelings toward the application and the potential issues that were presented with it. This result was then compared to the principles and guidelines used during the design to see whether any of the guidelines could be seen as faulty or if any potential guidelines were missing. The analysis of the research showed that most principles and guidelines were very helpful and brought the quality of the prototype to a satisfactory level on most accounts. The attitude towards some of the guidelines was proven to have changed since their emergence though. Finally, the paper also discovered, based on the applicant’s answers, that an application like this could increase the motivation of becoming a member in the “Cinema Club”.

This thesis presents the design, construction, and control of a two-wheeled inverted pendulum (TWIP) robotic walker prototype for assisting mobility-impaired users with balance and fall prevention. A conceptual model of the robotic walker is developed and used to illustrate the purpose of this study. A linearized mathematical model of the two-wheeled system is derived using Newtonian mechanics. A control strategy consisting of a decoupled LQR controller and three state variable controllers is developed to stabilize the platform and regulate its behavior with robust disturbance rejection performance. Simulation results reveal that the LQR controller is capable of stabilizing the platform and rejecting external disturbances while the state variable controllers simultaneously regulate the system’s position with smooth and minimum jerk control. A prototype for the two-wheeled system is fabricated and assembled followed by the implementation and tuning of the control algorithms responsible for stabilizing the prototype and regulating its position with optimal performance. Several experiments are conducted, confirming the ability of the decoupled LQR controller to robustly balance the platform while the state variable controllers regulate the platform’s position with smooth and minimum jerk control.

The covid-19 pandemic initiated this master thesis project. The pandemic has spread globally causing a lot of fear and uncertainty. We noticed the big shift in people’s daily routines, with the current state being that many individuals are stuck at home, scared to go outside, scared to meet with family members that are within the risk group. The future is very uncertain, people not knowing when society will return to normal. To provide people with a sense of safety, a tool for an easier daily routine, the feeling of more control in their daily lives, an opportunity to help others. These are all purposes that embody the reason for this master thesis.The goal of this master thesis project is to develop a digital prototype of an application concept. The application’s purpose is to provide users with insight of high activity areas of people in their vicinity or specific locations, to hopefully result in the user feeling more in control and hence more safe. The workflow used in this project is based on design thinking, using experience gained from the industrial design engineering program combined with research on the topic of user interfaces to develop and test the concept. The focus of the research in this thesis is placed heavily on usability and graphic design.The process was divided into phases following the process of design thinking, with potential users included in every phase. From interviews, questionnaires and personas during the first phase of context immersion to workshops during the second phase, ideation, to finally usability testing during the third phase, implementation. To ensure that the needs of the user were always focused on throughout the entirety of this master thesis we included potential users in each phase of the project. During the different phases, Tensaii AB provided guidance on decisions made by us, as well as provided feedback on specific methods and results presented during the weekly meetings.The result of this master thesis is an application prototype, the design based on all the data gained from participants and collected literature. A design that, through a high level of usability, enables a wider group of users to easily use it. The concept was named Milocus, translated from Latin to ”my place”. An application that through a check in function can collect data about activity in different areas. The application clearly shows the activity to the user through three categories, calm, busy and very busy. The color choices and design of the application were made using the online tool Material Design.

The author of this diploma thesis deals with the Proposal of a Risk Analysis Procedure in Technological Preparation for Foundry. Risk management is not currently applied in much detail at this present time. Analysis of the present risk management process in serial and prototype model tools will lead to the identification of risks within this discussion. It is then proposed for corrective actions for improvement of managing the current status to be presented and discussed. Target of this thesis is therefore the proposal of an updated risk analysis procedure in technological preparation for foundry.

The object of my master’s thesis is the analysis and design of an information system for the company SAP ČR spol. s r.o., which will facilitate the process of monitoring the development of Fiori applications. The work contains a theoretical background, as a basis for processing analyses that are focused on the user. The following is the design of the information system, which helps to improve the company's internal processes.

The aim of this diploma thesis is to design active frequency filters based on passive RLC prototype. Three methods of the design of active filters and active functional blocks of electronic circuits working in current or mixed mode are used to this purpose. These blocks allow to process electrical signals with frequencies up to low tens of megahertz. In addition they feature for instance with high slew rate and low supply voltage power. Active high-pass and low-pass 2nd order filters are designed using simulation of inductor by active subcircuit method. Grounded and subsequently floating synthetic inductor is made with the current conveyors in the first case and with the current operational amplifiers with single input and differential output in the second case. This method advantage is relatively simple design and disadvantage is great quantity of active functional blocks. Active filters based on passive frequency ladder 3rd order filter while only one floating inductor is connected, are designed with circuit equation method. In the first design differential input / output current followers are used and in the second case current-differencing buffered amplifiers are used. This method benefits by smaller active blocks number and disadvantage is more complex design of the active filter. Active filter based on passive prototype of low-pass 3rd order filter with two floating inductors is designed with Bruton transformation method. Final active filter uses current operational amplifiers with single input and differential output which together with other passive elements replace frequency depending negative resistor, which arise after previous Bruton transform. This method usage is advantageous if the design consists of larger quantity of inductors and less number of capacitors. High-pass 2nd order filter is simulated by tolerance and parametrical analyses. Physical realisation utilising current feedback operational amplifier which substitute commercially hardly accessible current conveyors is subsequently made. Measurements of constructed active filter show that additional modifications, which allow better amplitude frequency characteristics conformity, are necessary.

The project developed under the engineering studies, solves the problem of production of a prototype car using modern technology, reverse engineering and CAD / CAM. Based on the literary study of the issue, was designed process of digitization of the physical model of car, including the treatment and processing of data. Follow-up step was to verify the production of the additive rapid prototyping technology - FDM method. Verification of the results was performed on a vertical milling cantilever FV 25 CNC with control system Heidenhain iTNC 530 using a cutting strategies by PowerMILL CAM software. At the end of the resulting models edit as necessary.

Some of today’s most popular digital platforms do not have any environmental policies. The growing volume of their data consumption contributes to an increase in environmental emissions. Young adults between the ages of 16-25 are the most frequent users of these platforms. However, previous studies also show that of all age groups, 16-25s also have the highest level of concern for climate change. The purpose of this study is thus to research if the age group 16-25 are aware of the phenomenon ’green data’ and that both their own and the general data consumption has an environmental impact. Furthermore the purpose of the study is to research if and how a marketingcampaign could impact this age group to alter their digital choices to platforms and apps with less environmental impact.  A quantitative survey revealed negative results on both counts. Additionally, to explore if a marketingcampaign could alter the age groups digital choices, an intervention was conducted as an Instagram prototype. The prototype was measured qualitatively through two focus groups, one exposed to the marketing campaign and one control. Although the intervention raised awareness among the exposed group, the results suggested one campaign alone would not be sufficient. Additionally, the results revealed that lack of availability of alternative platforms, platform choices amongst peers, and convenience, mitigated the effectiveness of the marketing campaign. Further research may prove valuable in investigating variables that neutralise the mitigating factors’ effects.