Ändamålet med föreliggande rapport har varit att undersöka åtta personliga skildringar för att ta reda på hur deras livsåskådning ser ut efter att ha brukat psykedeliska substanser, samt undersöka huruvida något möte med Gud eller någon annan ”högre makt”, förekom under rusningstiden. För att besvara ändamålet har rapporten brutits ner till två frågeställningar, där den första hanterar vad som händer med livsåskådningen och det andra gudsmötet. För att besvara frågeställningarna har en kvalitativ innehållsanalys med förbestämda kodscheman och analysenheter använts som metod. Undersökningen teoretiseras och stärks dessutom med hjälp av den tidigare forskning som har gjorts på området från John Hopkins universitet, men även med hjälp av teoretiska begrepp som b.la. mysticism, livsåskådning och shamanism. Denna undersökningens resultat stämmer väl överens med tidigare forskning och visar att psykedeliska substanser tenderar att påverka eller förändra en människas livsåskådning till att börja uppskatta andlighet mer än det materiella och att de flesta upplevde någon form av ”högre makt”.

Background: Psilocybin is today the most studied psychedelic substance in neuroscience for its psychotomimetic and therapeutic effects. One of the institutions in the Czech Republic that studies this substance is the National Institute of Mental Health, where a clinical evaluation of its effects and safety is underway. The action and safety of this substance is examined here in terms of acute intoxication, but also in terms of long-term effects. Aim: To determine how volunteers perceive the experience with psilocybin administered in a controlled experimental study environment and whether they have experienced any afterglow effects after the cessation of acute intoxication for 28 days after administration, as well as how these effects occur and how long they persist. Methods: Data was obtained using semi-structured interviews. The research group consists of 20 interviews with 10 healthy volunteers of the clinical study at NUDZ. Interviews were conducted on day 28 after administration of an active dose of psilocybin or placebo. A qualitative thematic analysis of these interviews was performed in order to identify topics within the framework set by the research questions. Results: The results showed that for the respondents, the experience with the active dose of psilocybin was significant in terms of...

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[pt] As substâncias psicodélicas clássicas são agonistas serotoninérgicos que atuam essencialmente no sistema de neurotransmissão 5HT2A. Essas substâncias podem promover estados alterados de consciência, bem como alterações visuais, afetivas, de humor e alterações cognitivas. Historicamente, eles têm sido usados para fins ritualísticos, recreativos e medicinais. Estudos indicam que essas substâncias apresentam baixa toxicidade, baixo risco de dependência e overdose. Existe um interesse científico atual no uso dessas substâncias como tratamento para uma variedade de condições e, embora muitos estudos busquem investigar objetivamente os resultados vinculados ao seu uso, os conteúdos subjetivos da experiência dos usuários ainda são pouco explorados. Considerando que a perspectiva de primeira pessoa é central para a experiência psicodélica, esta tese buscou investigar experiências subjetivas ligadas a psicodélicos por meio de uma variedade de abordagens. Primeiramente, buscou-se adaptar e validar o Ego Dissolution Inventory (EDI), instrumento amplamente utilizado por pesquisadores para avaliar um fenômeno essencial da experiência psicodélica, para o contexto brasileiro (Artigo 1). Em seguida, buscou-se explorar relatos públicos negativos (Artigo 2) e positivos (Artigo 3) de usuários de psilocibina (princípio ativo dos cogumelos mágicos), por meio do método Reinert, que analisa quantitativamente as falas transcritas. Por fim, discutiu-se a possível influência dos estados alterados de consciência (ASC), incluindo aqueles relacionados ao uso de substâncias psicoativas, na evolução humana (Artigo 4), sugerindo futuras pesquisas para explorar essa hipótese. / [en] Classical psychedelic substances are serotonergic agonists that act essentially on the 5HT2A neurotransmission system. These substances can promote altered states of consciousness, as well as visual, affective, mood, and cognitive changes. Historically, they have been used for ritualistic, recreational, and medicinal purposes. Studies indicate that these substances have low toxicity, low risk of dependence and overdose. There is current scientific interest in the use of these substances as a treatment for a variety of conditions, and while many studies seek to objectively investigate outcomes linked to their use, the subjective contents of the experience of users is seldom explored. Since a first-person perspective is central to the psychedelic experience, this thesis sought to investigate subjective experiences linked to psychedelics through a variety of approaches. First, we sought to adapt and validate the Ego Dissolution Inventory (EDI), an instrument widely used by researchers to assess a central feature of the psychedelic experience, to the Brazilian context (Article 1). Then, we sought to explore public negative (Article 2) and positive (Article 3) reports of psilocybin (the active principle of magic mushrooms) users, through the Reinert method, which quantitatively analyses transcribed speeches. Finally, the possible influence of altered states of consciousness (ASC), including those linked to use of psychoactive substances, in human evolution was discussed (Article 4), suggesting future research to explore this hypothesis.

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